RRP1B ribosomal RNA processing 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: RRP1Bprovided by HGNC
Official Full Name: ribosomal RNA processing 1Bprovided by HGNC
Primary source: HGNC:HGNC:23818
See related: Ensembl:ENSG00000160208 MIM:610654; Vega:OTTHUMG00000086872
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Nnp1; RRP1; NNP1L; KIAA0179; PPP1R136
Expression: Ubiquitous expression in lymph node (RPKM 10.6), testis (RPKM 10.3) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 21q22.3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	21	NC_000021.9 (43659551..43696079)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (45079432..45115960)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis
Title: The contribution of SIPA1 and RRP1B germline polymorphisms to breast cancer phenotype, lymph node status and survival in a group of Lithuanian young breast cancer patients.
this study characterized the rRNA processing 1 homolog B (RRP1B) protein as an important cellular factor for influenza A virus transcription.
Title: A Nucleolar Protein, Ribosomal RNA Processing 1 Homolog B (RRP1B), Enhances the Recruitment of Cellular mRNA in Influenza Virus Transcription.
Data show that RRP1B regulates metastasis associated gene expression by interacting with the transcriptional corepressors TRIM28 and HP1a, which act by recruiting chromatin-modifying enzymes.
Title: Metastasis-associated protein ribosomal RNA processing 1 homolog B (RRP1B) modulates metastasis through regulation of histone methylation.
Presence of Rrp1b1307TT genotype and T allele confer strong risk for breast cancer development and progression.
Title: Rrp1B gene polymorphism (1307T>C) in metastatic progression of breast cancer.
BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.
Title: BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.
Expression of RRP1B, PCNT, KIF21A and ADRB2 in leucocytes of Down's syndrome subjects, was analyzed.
Title: Gene expression profiling and qRT-PCR expression of RRP1B, PCNT, KIF21A and ADRB2 in leucocytes of Down's syndrome subjects.
identified and characterized a major nucleolar pool of PP1 targeted to pre-60S ribosomal subunit processing complexes by RRP1B
Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
E2F1 makes use of its transcriptional target RRP1B to activate other genes directly involved in apoptosis.
Title: Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-81310 (e-PCR)
- UniSTS:102676

G34629 (e-PCR)
- UniSTS:19223

G34564 (e-PCR)
- UniSTS:22861

SHGC-51981 (e-PCR)
- UniSTS:38999

SHGC-7009 (e-PCR)
- UniSTS:37480

RH25394 (e-PCR)
- UniSTS:90217

D21S1875 (e-PCR)
- UniSTS:1415

SHGC-51780 (e-PCR)
- UniSTS:26015

SHGC-52104 (e-PCR)
- UniSTS:80309

D21S1871 (e-PCR)
- UniSTS:71894

D21S1995 (e-PCR)
- UniSTS:1018

Homology

Homologs of the RRP1B gene: The RRP1B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 193 organisms have orthologs with human gene RRP1B
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
RNA binding	HDA more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
RNA splicing	IEA Inferred from Electronic Annotation more info
apoptotic process	IEA Inferred from Electronic Annotation more info
cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
mRNA processing	IEA Inferred from Electronic Annotation more info
negative regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation by host of viral transcription	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
rRNA processing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
cytosol	HDA more info	PubMed
euchromatin	IEA Inferred from Electronic Annotation more info
granular component	IDA Inferred from Direct Assay more info	PubMed
heterochromatin	IEA Inferred from Electronic Annotation more info
nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	IEA Inferred from Electronic Annotation more info
nucleus	HDA more info	PubMed
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info	PubMed
preribosome, small subunit precursor	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal RNA processing protein 1 homolog B

Names: RRP1-like protein B; protein phosphatase 1, regulatory subunit 136; ribosomal RNA processing 1 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.