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RRP1B ribosomal RNA processing 1B [ Homo sapiens (human) ]

Gene ID: 23076, updated on 6-Jul-2025
Official Symbol
RRP1Bprovided by HGNC
Official Full Name
ribosomal RNA processing 1Bprovided by HGNC
Primary source
HGNC:HGNC:23818
See related
Ensembl:ENSG00000160208 MIM:610654; AllianceGenome:HGNC:23818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nnp1; RRP1; NNP1L; KIAA0179; PPP1R136
Summary
Enables transcription coactivator activity. Involved in cellular response to virus; positive regulation of apoptotic process; and positive regulation of transcription by RNA polymerase II. Located in chromosome; granular component; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in lymph node (RPKM 10.6), testis (RPKM 10.3) and 25 other tissues See more
Orthologs
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See RRP1B in Genome Data Viewer
Location:
21q22.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (43659560..43696079)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42015103..42051622)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45079441..45115960)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 2 binding protein Neighboring gene H2B clustered histone 12 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:45003551-45004052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13361 Neighboring gene microRNA 6070 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18545 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:45094121-45094620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13363 Neighboring gene uncharacterized LOC124905030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45127109-45127642 Neighboring gene uncharacterized LOC124905031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45131022-45131903 Neighboring gene RRP1B-PDXK intergenic CAGE-defined mid-level expression enhancer

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • KIAA0179

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation by host of viral transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
located_in euchromatin IEA
Inferred from Electronic Annotation
more info
 
located_in granular component IDA
Inferred from Direct Assay
more info
PubMed 
located_in heterochromatin IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of preribosome, small subunit precursor IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ribosomal RNA processing protein 1 homolog B
Names
RRP1-like protein B
protein phosphatase 1, regulatory subunit 136
ribosomal RNA processing 1 homolog B

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015056.3NP_055871.1  ribosomal RNA processing protein 1 homolog B

    See identical proteins and their annotated locations for NP_055871.1

    Status: VALIDATED

    Source sequence(s)
    AK056263, AK124620, AP001052, BC028386, BE544027, BX479134
    Consensus CDS
    CCDS33577.1
    UniProtKB/Swiss-Prot
    Q14684, Q8TBZ4
    Related
    ENSP00000339145.4, ENST00000340648.6
    Conserved Domains (1) summary
    pfam05997
    Location:10218
    Nop52; Nucleolar protein,Nop52

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    43659560..43696079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    42015103..42051622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)