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Thrap3 thyroid hormone receptor associated protein 3 [ Mus musculus (house mouse) ]

Gene ID: 230753, updated on 26-Mar-2024

Summary

Official Symbol
Thrap3provided by MGI
Official Full Name
thyroid hormone receptor associated protein 3provided by MGI
Primary source
MGI:MGI:2442637
See related
Ensembl:ENSMUSG00000043962 AllianceGenome:MGI:2442637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trap150; 9330151F09Rik; B230333E16Rik
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coactivator activity. Acts upstream of or within circadian rhythm. Part of mediator complex. Is expressed in brain; branchial arch; genitourinary system; limb; and retina nuclear layer. Orthologous to human THRAP3 (thyroid hormone receptor associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 45.1), limb E14.5 (RPKM 31.5) and 28 other tissues See more
Orthologs
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Genomic context

See Thrap3 in Genome Data Viewer
Location:
4 D2.2; 4 60.0 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126057875..126096548, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126164082..126202755, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene eva-1 homolog B Neighboring gene SH3 domain containing 21 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125839584-125839767 Neighboring gene STARR-seq mESC enhancer starr_11390 Neighboring gene STARR-seq mESC enhancer starr_11391 Neighboring gene STARR-seq mESC enhancer starr_11392 Neighboring gene predicted gene, 25323 Neighboring gene MAP7 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6217 Neighboring gene STARR-positive B cell enhancer ABC_E2122 Neighboring gene trafficking protein particle complex 3 Neighboring gene predicted gene, 54258

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC37192, MGC56927, MGC98683, MGC116673

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thyroid hormone receptor-associated protein 3
Names
thyroid hormone receptor-associated protein complex 150 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356455.1NP_001343384.1  thyroid hormone receptor-associated protein 3

    Status: VALIDATED

    Source sequence(s)
    AL732624, BB855884, BC092239
    Consensus CDS
    CCDS18645.1
    UniProtKB/Swiss-Prot
    Q569Z6
    Conserved Domains (1) summary
    pfam15440
    Location:191766
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
  2. NM_001356456.1NP_001343385.1  thyroid hormone receptor-associated protein 3

    Status: VALIDATED

    Source sequence(s)
    AL732624, BB855884, BC092239
    Consensus CDS
    CCDS18645.1
    UniProtKB/Swiss-Prot
    Q569Z6
    Conserved Domains (1) summary
    pfam15440
    Location:191766
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
  3. NM_146153.3NP_666265.3  thyroid hormone receptor-associated protein 3

    See identical proteins and their annotated locations for NP_666265.3

    Status: VALIDATED

    Source sequence(s)
    BC092239, BY327148
    Consensus CDS
    CCDS18645.1
    UniProtKB/Swiss-Prot
    Q569Z6
    Related
    ENSMUSP00000079722.6, ENSMUST00000080919.12
    Conserved Domains (1) summary
    pfam15440
    Location:191766
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    126057875..126096548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164049.1XP_036019942.1  thyroid hormone receptor-associated protein 3 isoform X2

    Conserved Domains (1) summary
    pfam15440
    Location:3484
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
  2. XM_036164048.1XP_036019941.1  thyroid hormone receptor-associated protein 3 isoform X2

    Conserved Domains (1) summary
    pfam15440
    Location:3484
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
  3. XM_036164047.1XP_036019940.1  thyroid hormone receptor-associated protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q569Z6
    Conserved Domains (1) summary
    pfam15440
    Location:191766
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

RNA

  1. XR_003954927.1 RNA Sequence

  2. XR_003954926.1 RNA Sequence