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Zmpste24 zinc metallopeptidase, STE24 [ Mus musculus (house mouse) ]

Gene ID: 230709, updated on 12-May-2024

Summary

Official Symbol
Zmpste24provided by MGI
Official Full Name
zinc metallopeptidase, STE24provided by MGI
Primary source
MGI:MGI:1890508
See related
Ensembl:ENSMUSG00000043207 AllianceGenome:MGI:1890508
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MADB; FACE1; STE24; Face-1; Ste24p; D030046F19; A530043O15Rik
Summary
Enables double-stranded DNA binding activity and metalloendopeptidase activity. Acts upstream of or within several processes, including animal organ development; regulation of intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in membrane and nuclear envelope. Is expressed in early conceptus. Used to study Emery-Dreifuss muscular dystrophy; familial partial lipodystrophy; and progeria. Human ortholog(s) of this gene implicated in connective tissue disease and lethal restrictive dermopathy. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 16.8), placenta adult (RPKM 12.9) and 28 other tissues See more
Orthologs
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Genomic context

See Zmpste24 in Genome Data Viewer
Location:
4 D2.2; 4 56.8 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120916434..120955452, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (121059237..121098249, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene small ArfGAP 2 Neighboring gene microRNA 7015 Neighboring gene STARR-positive B cell enhancer ABC_E6209 Neighboring gene STARR-positive B cell enhancer ABC_E3508 Neighboring gene STARR-positive B cell enhancer ABC_E10255 Neighboring gene STARR-positive B cell enhancer ABC_E6210 Neighboring gene STARR-seq mESC enhancer starr_11259 Neighboring gene collagen, type IX, alpha 2 Neighboring gene predicted gene, 23540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:120770755-120770962 Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene predicted gene 12882

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CAAX-box protein processing IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within CAMKK-AMPK signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA repair IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone mineralization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within calcium ion import into sarcoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac ventricle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within growth plate cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maintenance of rDNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of miRNA processing IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuromuscular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear envelope organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nuclear envelope organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within nuclear envelope organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear envelope organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nucleus organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression via chromosomal CpG island demethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within prenylated protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of DNA damage response, signal transduction by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of RNA polymerase II regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of blood circulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of bone mineralization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cellular senescence IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mitotic cell cycle DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of stress-activated protein kinase signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of termination of RNA polymerase I transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
CAAX prenyl protease 1 homolog
Names
farnesylated-proteins converting enzyme 1
prenyl protein-specific endoprotease 1
zinc metallopeptidase, STE24 homolog
zinc metalloproteinase, STE24 homolog
NP_766288.1
XP_006503082.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172700.3NP_766288.1  CAAX prenyl protease 1 homolog

    See identical proteins and their annotated locations for NP_766288.1

    Status: VALIDATED

    Source sequence(s)
    AL669949
    Consensus CDS
    CCDS18600.1
    UniProtKB/Swiss-Prot
    Q80W54, Q8BJK4, Q8K569
    UniProtKB/TrEMBL
    B9EHY2
    Related
    ENSMUSP00000053900.3, ENSMUST00000058754.9
    Conserved Domains (3) summary
    COG0501
    Location:124474
    HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
    pfam01435
    Location:228471
    Peptidase_M48; Peptidase family M48
    pfam16491
    Location:41225
    Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    120916434..120955452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503019.2XP_006503082.1  CAAX prenyl protease 1 homolog isoform X1

    See identical proteins and their annotated locations for XP_006503082.1

    Conserved Domains (1) summary
    cd07343
    Location:22490
    M48A_Zmpste24p_like; Peptidase M48 subfamily A, a type 1 CaaX endopeptidase