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CMTR1 cap methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 23070, updated on 3-Mar-2024

Summary

Official Symbol
CMTR1provided by HGNC
Official Full Name
cap methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:21077
See related
Ensembl:ENSG00000137200 MIM:616189; AllianceGenome:HGNC:21077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTr1; hMTr1; FTSJD2; KIAA0082
Summary
Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping and cap1 mRNA methylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 31.1), spleen (RPKM 12.4) and 25 other tissues See more
Orthologs
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Genomic context

See CMTR1 in Genome Data Viewer
Location:
6p21.2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (37423985..37481508)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (37247428..37305049)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (37400997..37449284)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24457 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:37335886-37337085 Neighboring gene RNA, 7SL, cytoplasmic 273, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7630 Neighboring gene ring finger protein 8 Neighboring gene uncharacterized LOC107986531 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:37400679-37401180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17140 Neighboring gene MPRA-validated peak5792 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:37427605-37428259 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:37448259-37448959 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:37456899-37457744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24459 Neighboring gene coiled-coil domain containing 167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37480625-37481226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37481227-37481828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37483099-37483883 Neighboring gene long intergenic non-protein coding RNA 2520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37483884-37484668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24462 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:37487335-37487506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24463

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ22156, KIAA0082

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA (nucleoside-2'-O-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in 7-methylguanosine mRNA capping IDA
Inferred from Direct Assay
more info
PubMed 
involved_in 7-methylguanosine mRNA capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cap1 mRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cap1 mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Names
FtsJ methyltransferase domain containing 2
ISG95
S-adenosyl-L-methionine-dependent methyltransferase FTSJD2
cap1 2'O-ribose methyltransferase 1
ftsJ methyltransferase domain-containing protein 2
interferon-stimulated gene 95 kDa protein
NP_055865.1
XP_047274418.1
XP_047274419.1
XP_054210779.1
XP_054210780.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015050.3NP_055865.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

    See identical proteins and their annotated locations for NP_055865.1

    Status: VALIDATED

    Source sequence(s)
    BC010731, BC031890, DA508836
    Consensus CDS
    CCDS4835.1
    UniProtKB/Swiss-Prot
    A8K949, Q14670, Q8N1G2, Q96FJ9
    Related
    ENSP00000362550.4, ENST00000373451.9
    Conserved Domains (3) summary
    pfam01585
    Location:87129
    G-patch; G-patch domain
    pfam01728
    Location:232448
    FtsJ; FtsJ-like methyltransferase
    cl12015
    Location:625716
    Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    37423985..37481508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418463.1XP_047274419.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K949, Q14670, Q8N1G2, Q96FJ9
  2. XM_047418462.1XP_047274418.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K949, Q14670, Q8N1G2, Q96FJ9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    37247428..37305049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354804.1XP_054210779.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K949, Q14670, Q8N1G2, Q96FJ9
  2. XM_054354805.1XP_054210780.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K949, Q14670, Q8N1G2, Q96FJ9