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CMTR1 cap methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 23070, updated on 21-Dec-2019

Summary

Official Symbol
CMTR1provided by HGNC
Official Full Name
cap methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:21077
See related
Ensembl:ENSG00000137200 MIM:616189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTr1; hMTr1; FTSJD2; KIAA0082
Expression
Ubiquitous expression in testis (RPKM 31.1), spleen (RPKM 12.4) and 25 other tissues See more
Orthologs

Genomic context

See CMTR1 in Genome Data Viewer
Location:
6p21.2
Exon count:
25
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (37433214..37482844)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (37400907..37450637)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375040 Neighboring gene RNA, 7SL, cytoplasmic 273, pseudogene Neighboring gene ring finger protein 8 Neighboring gene translation initiation factor IF-2-like Neighboring gene coiled-coil domain containing 167 Neighboring gene long intergenic non-protein coding RNA 2520

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22156, KIAA0082

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA (nucleoside-2'-O-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
7-methylguanosine mRNA capping IDA
Inferred from Direct Assay
more info
PubMed 
7-methylguanosine mRNA capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
cap1 mRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cap1 mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Names
FtsJ methyltransferase domain containing 2
ISG95
S-adenosyl-L-methionine-dependent methyltransferase FTSJD2
cap1 2'O-ribose methyltransferase 1
ftsJ methyltransferase domain-containing protein 2
interferon-stimulated gene 95 kDa protein
NP_055865.1
XP_005249012.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015050.3NP_055865.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

    See identical proteins and their annotated locations for NP_055865.1

    Status: VALIDATED

    Source sequence(s)
    BC010731, BC031890, DA508836
    Consensus CDS
    CCDS4835.1
    UniProtKB/Swiss-Prot
    Q8N1G2
    Related
    ENSP00000362550.4, ENST00000373451.9
    Conserved Domains (3) summary
    pfam01585
    Location:87129
    G-patch; G-patch domain
    pfam01728
    Location:232448
    FtsJ; FtsJ-like methyltransferase
    cl12015
    Location:625716
    Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    37433214..37482844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248955.4XP_005249012.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005249012.1

    Conserved Domains (3) summary
    pfam01585
    Location:87129
    G-patch; G-patch domain
    pfam01728
    Location:232448
    FtsJ; FtsJ-like methyltransferase
    cl12015
    Location:625716
    Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases

RNA

  1. XR_001743272.2 RNA Sequence

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