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Tesk2 testis-specific kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 230661, updated on 26-Sep-2022

Summary

Official Symbol
Tesk2provided by MGI
Official Full Name
testis-specific kinase 2provided by MGI
Primary source
MGI:MGI:2385204
See related
Ensembl:ENSMUSG00000033985 AllianceGenome:MGI:2385204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in actin cytoskeleton organization; focal adhesion assembly; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human TESK2 (testis associated actin remodelling kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 12.8), large intestine adult (RPKM 7.1) and 27 other tissues See more
Orthologs
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Genomic context

See Tesk2 in Genome Data Viewer
Location:
4; 4 D1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116578107..116661450)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116720909..116804248)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AV051173 Neighboring gene peroxiredoxin 1 Neighboring gene methylmalonic aciduria cblC type, with homocystinuria Neighboring gene coiled-coil domain containing 163 Neighboring gene target of EGR1, member 1 (nuclear) Neighboring gene mutY DNA glycosylase Neighboring gene 4-hydroxyphenylpyruvate dioxygenase-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC29168

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity testis-specific protein kinase 2
Names
testicular protein kinase 2
NP_666263.3
XP_006503071.1
XP_030109303.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146151.4NP_666263.3  dual specificity testis-specific protein kinase 2

    See identical proteins and their annotated locations for NP_666263.3

    Status: VALIDATED

    Source sequence(s)
    AK047755, AL683847
    Consensus CDS
    CCDS18516.1
    UniProtKB/Swiss-Prot
    Q8VCT9
    Related
    ENSMUSP00000041009.7, ENSMUST00000045542.13
    Conserved Domains (2) summary
    smart00219
    Location:62309
    TyrKc; Tyrosine kinase, catalytic domain
    cd14155
    Location:64316
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116578107..116661450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253443.2XP_030109303.1  dual specificity testis-specific protein kinase 2 isoform X1

    Conserved Domains (1) summary
    cd14155
    Location:144396
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase
  2. XM_006503008.5XP_006503071.1  dual specificity testis-specific protein kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1200
    PKc_like; Protein Kinases, catalytic domain