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CAND2 cullin associated and neddylation dissociated 2 (putative) [ Homo sapiens (human) ]

Gene ID: 23066, updated on 4-Jul-2021

Summary

Official Symbol
CAND2provided by HGNC
Official Full Name
cullin associated and neddylation dissociated 2 (putative)provided by HGNC
Primary source
HGNC:HGNC:30689
See related
Ensembl:ENSG00000144712 MIM:610403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Tp120b; TIP120B
Expression
Broad expression in heart (RPKM 9.1), testis (RPKM 8.9) and 16 other tissues See more
Orthologs
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Genomic context

See CAND2 in Genome Data Viewer
Location:
3p25.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (12796654..12834818)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12838179..12876302)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 40 Neighboring gene keratin 18 pseudogene 17 Neighboring gene ribosomal protein L32 Neighboring gene small nucleolar RNA, H/ACA box 7A Neighboring gene microtubule affinity regulating kinase 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 IN is identified to have a physical interaction with Cullin-associated and neddylation-dissociated 2 (CAND2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0667

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in SCF complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cullin-associated NEDD8-dissociated protein 2
Names
TBP interacting protein
TBP-interacting protein 120B
TBP-interacting protein of 120 kDa B
cullin-associated and neddylation-dissociated protein 2
epididymis secretory sperm binding protein
epididymis tissue protein Li 169
p120 CAND2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162499.2NP_001155971.1  cullin-associated NEDD8-dissociated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001155971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB014567, BC136592, BX502783, DR001490, W44800
    Consensus CDS
    CCDS54554.1
    UniProtKB/Swiss-Prot
    O75155
    Related
    ENSP00000387641.2, ENST00000456430.6
    Conserved Domains (4) summary
    pfam08623
    Location:10581207
    TIP120; TATA-binding protein interacting (TIP20)
    pfam13513
    Location:150202
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:834908
    HEAT_2; HEAT repeats
    sd00044
    Location:864887
    HEAT; HEAT repeat [structural motif]
  2. NM_012298.3NP_036430.1  cullin-associated NEDD8-dissociated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_036430.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing two in-frame coding exons, and uses an alternate in-frame acceptor splice site at one of the coding exons, compared to variant 1. This results in a shorter isoform (2) lacking two internal protein segments compared to isoform 1.
    Source sequence(s)
    AB014567, BC136592, BX502783, DR001490, W44800
    Consensus CDS
    CCDS43053.1
    UniProtKB/Swiss-Prot
    O75155
    Related
    ENSP00000295989.5, ENST00000295989.9
    Conserved Domains (3) summary
    pfam08623
    Location:9411090
    TIP120; TATA-binding protein interacting (TIP20)
    pfam13646
    Location:741815
    HEAT_2; HEAT repeats
    sd00044
    Location:701725
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    12796654..12834818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533503.2XP_011531805.1  cullin-associated NEDD8-dissociated protein 2 isoform X1

    Conserved Domains (4) summary
    pfam08623
    Location:10581136
    TIP120; TATA-binding protein interacting (TIP20)
    pfam13513
    Location:150202
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:834908
    HEAT_2; HEAT repeats
    sd00044
    Location:864887
    HEAT; HEAT repeat [structural motif]
  2. XM_011533504.2XP_011531806.1  cullin-associated NEDD8-dissociated protein 2 isoform X2

    Conserved Domains (4) summary
    pfam08623
    Location:10341183
    TIP120; TATA-binding protein interacting (TIP20)
    pfam13513
    Location:126178
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:810884
    HEAT_2; HEAT repeats
    sd00044
    Location:840863
    HEAT; HEAT repeat [structural motif]
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