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Zyg11a zyg-11 family member A, cell cycle regulator [ Mus musculus (house mouse) ]

Gene ID: 230590, updated on 26-Sep-2022

Summary

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Official Symbol
Zyg11aprovided by MGI
Official Full Name
zyg-11 family member A, cell cycle regulatorprovided by MGI
Primary source
MGI:MGI:2446208
See related
Ensembl:ENSMUSG00000034645 AllianceGenome:MGI:2446208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human ZYG11A (zyg-11 family member A, cell cycle regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 1.6), mammary gland adult (RPKM 1.2) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Zyg11a in Genome Data Viewer
Location:
4; 4 C7
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108037442..108075285, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108180245..108218088, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54248 Neighboring gene enoyl Coenzyme A hydratase domain containing 2 Neighboring gene predicted gene, 54249 Neighboring gene zyg-ll family member B, cell cycle regulator Neighboring gene cytochrome c oxidase assembly factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
protein zyg-11 homolog A
Names
zyg-11 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167936.3 → NP_001161408.2  protein zyg-11 homolog A

    Status: VALIDATED

    Source sequence(s)
    BX293563
    Consensus CDS
    CCDS51256.2
    UniProtKB/TrEMBL
    A0A217FL76
    Related
    ENSMUSP00000102301.3, ENSMUST00000106690.9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    108037442..108075285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502976.4 → XP_006503039.1  protein zyg-11 homolog A isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VNL1
    Related
    ENSMUSP00000152477.2, ENSMUST00000223127.2
    Conserved Domains (2) summary
    COG4886
    Location:156 → 294
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00034
    Location:158 → 182
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. XM_017320136.1 → XP_017175625.1  protein zyg-11 homolog A isoform X2

    Conserved Domains (2) summary
    COG4886
    Location:56 → 194
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00034
    Location:58 → 82
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2BFL2.1 GenPept UniProtKB/Swiss-Prot:A2BFL2

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