U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cyb5rl cytochrome b5 reductase-like [ Mus musculus (house mouse) ]

Gene ID: 230582, updated on 5-Mar-2024

Summary

Official Symbol
Cyb5rlprovided by MGI
Official Full Name
cytochrome b5 reductase-likeprovided by MGI
Primary source
MGI:MGI:1919657
See related
Ensembl:ENSMUSG00000028621 AllianceGenome:MGI:1919657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810410C14Rik
Summary
Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be located in nucleoplasm. Is expressed in cranial ganglion; dorsal root ganglion; and trigeminal nerve. Orthologous to human CYB5RL (cytochrome b5 reductase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 3.0), kidney adult (RPKM 2.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cyb5rl in Genome Data Viewer
Location:
4 C7; 4 49.99 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106924035..106945204)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107066830..107088007)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6196 Neighboring gene predicted gene, 52672 Neighboring gene single-stranded DNA binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_11016 Neighboring gene STARR-seq mESC enhancer starr_11017 Neighboring gene STARR-positive B cell enhancer ABC_E3500 Neighboring gene VISTA enhancer mm1261 Neighboring gene STARR-positive B cell enhancer ABC_E1035 Neighboring gene mitochondrial ribosomal protein L37 Neighboring gene CUB domain containing protein 2 Neighboring gene predicted gene 12802 Neighboring gene transcription elongation factor A (SII) N-terminal and central domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General protein information

Preferred Names
NADH-cytochrome b5 reductase-like
NP_001333481.1
NP_001364012.1
NP_001364013.1
NP_001364014.1
NP_001364015.1
NP_001364016.1
NP_001364017.1
NP_780680.1
XP_006503009.1
XP_006503010.1
XP_006503011.1
XP_006503013.1
XP_006503014.1
XP_006503015.1
XP_006503017.1
XP_006503018.1
XP_006503020.1
XP_006503022.1
XP_006503025.1
XP_011238784.1
XP_011238786.1
XP_017175622.1
XP_030109289.1
XP_036019906.1
XP_036019907.1
XP_036019908.1
XP_036019909.1
XP_036019910.1
XP_036019911.1
XP_036019912.1
XP_036019913.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346552.2NP_001333481.1  NADH-cytochrome b5 reductase-like isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AL607132
    Consensus CDS
    CCDS84765.1
    UniProtKB/Swiss-Prot
    B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7
    Related
    ENSMUSP00000102369.2, ENSMUST00000106758.8
    Conserved Domains (2) summary
    cd06183
    Location:83316
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1352
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  2. NM_001377083.1NP_001364012.1  NADH-cytochrome b5 reductase-like isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 4, encodes isoform 1.
    Source sequence(s)
    AL607132
    UniProtKB/Swiss-Prot
    B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7
    Conserved Domains (2) summary
    cd06183
    Location:83316
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1352
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  3. NM_001377084.1NP_001364013.1  NADH-cytochrome b5 reductase-like isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1 and 3, encodes isoform 1.
    Source sequence(s)
    AL607132
    UniProtKB/Swiss-Prot
    B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7
    Conserved Domains (2) summary
    cd06183
    Location:83316
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1352
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  4. NM_001377085.1NP_001364014.1  NADH-cytochrome b5 reductase-like isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform 3.
    Source sequence(s)
    AL607132
    Conserved Domains (2) summary
    cd06183
    Location:83249
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1352
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  5. NM_001377086.1NP_001364015.1  NADH-cytochrome b5 reductase-like isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 5, encodes isoform 3.
    Source sequence(s)
    AL607132
    Conserved Domains (2) summary
    cd06183
    Location:83249
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1352
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  6. NM_001377087.1NP_001364016.1  NADH-cytochrome b5 reductase-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL607132
    Conserved Domains (2) summary
    cd06183
    Location:83249
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1352
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  7. NM_001377088.1NP_001364017.1  NADH-cytochrome b5 reductase-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL607132
    Conserved Domains (2) summary
    cd06183
    Location:83264
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1352
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  8. NM_175471.4NP_780680.1  NADH-cytochrome b5 reductase-like isoform 2

    See identical proteins and their annotated locations for NP_780680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL607132
    Consensus CDS
    CCDS38829.1
    UniProtKB/Swiss-Prot
    B1AS42
    Related
    ENSMUSP00000102367.3, ENSMUST00000106756.9
    Conserved Domains (1) summary
    cd06183
    Location:23256
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    106924035..106945204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240482.4XP_011238784.1  NADH-cytochrome b5 reductase-like isoform X7

    Conserved Domains (2) summary
    cd06183
    Location:147355
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:77116
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  2. XM_030253429.2XP_030109289.1  NADH-cytochrome b5 reductase-like isoform X10

    Conserved Domains (2) summary
    cd06183
    Location:147313
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:77116
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  3. XM_036164016.1XP_036019909.1  NADH-cytochrome b5 reductase-like isoform X16

    Conserved Domains (2) summary
    cd06183
    Location:147278
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:77116
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  4. XM_017320133.3XP_017175622.1  NADH-cytochrome b5 reductase-like isoform X20

    Conserved Domains (2) summary
    pfam09791
    Location:77116
    Oxidored-like; Oxidoreductase-like protein, N-terminal
    cl06868
    Location:147211
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
  5. XM_006502946.5XP_006503009.1  NADH-cytochrome b5 reductase-like isoform X1

    Conserved Domains (2) summary
    cd06183
    Location:147355
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:77116
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  6. XM_006502947.5XP_006503010.1  NADH-cytochrome b5 reductase-like isoform X2

    Conserved Domains (2) summary
    cd06183
    Location:147422
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:77116
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  7. XM_006502950.5XP_006503013.1  NADH-cytochrome b5 reductase-like isoform X4

    Conserved Domains (2) summary
    cd06183
    Location:147313
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:77116
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  8. XM_006502954.5XP_006503017.1  NADH-cytochrome b5 reductase-like isoform X6

    Conserved Domains (2) summary
    cd06183
    Location:147278
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:77116
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  9. XM_006502955.4XP_006503018.1  NADH-cytochrome b5 reductase-like isoform X8

    Conserved Domains (2) summary
    cd06183
    Location:147345
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:77116
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  10. XM_006502948.5XP_006503011.1  NADH-cytochrome b5 reductase-like isoform X3

    Conserved Domains (2) summary
    cd06183
    Location:123331
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:5392
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  11. XM_036164013.1XP_036019906.1  NADH-cytochrome b5 reductase-like isoform X9

    Conserved Domains (2) summary
    cd06183
    Location:123254
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:5392
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  12. XM_036164014.1XP_036019907.1  NADH-cytochrome b5 reductase-like isoform X12

    Conserved Domains (2) summary
    cd06183
    Location:123321
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:5392
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  13. XM_036164018.1XP_036019911.1  NADH-cytochrome b5 reductase-like isoform X18

    Conserved Domains (2) summary
    cd06183
    Location:147244
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:77116
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  14. XM_036164019.1XP_036019912.1  NADH-cytochrome b5 reductase-like isoform X19

    Conserved Domains (2) summary
    cd06183
    Location:123220
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:5392
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  15. XM_006502957.5XP_006503020.1  NADH-cytochrome b5 reductase-like isoform X11

    Conserved Domains (2) summary
    pfam09791
    Location:77116
    Oxidored-like; Oxidoreductase-like protein, N-terminal
    cl06868
    Location:147210
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
  16. XM_006502952.5XP_006503015.1  NADH-cytochrome b5 reductase-like isoform X5

    See identical proteins and their annotated locations for XP_006503015.1

    Conserved Domains (2) summary
    cd06183
    Location:83291
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1352
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  17. XM_036164015.1XP_036019908.1  NADH-cytochrome b5 reductase-like isoform X14

    UniProtKB/Swiss-Prot
    B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7
    Conserved Domains (2) summary
    cd06183
    Location:83316
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1352
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  18. XM_036164020.1XP_036019913.1  NADH-cytochrome b5 reductase-like isoform X21

    Conserved Domains (1) summary
    cd06183
    Location:23189
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
  19. XM_006502959.4XP_006503022.1  NADH-cytochrome b5 reductase-like isoform X13

    See identical proteins and their annotated locations for XP_006503022.1

    Conserved Domains (1) summary
    cd06183
    Location:23231
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
  20. XM_006502951.4XP_006503014.1  NADH-cytochrome b5 reductase-like isoform X5

    See identical proteins and their annotated locations for XP_006503014.1

    Conserved Domains (2) summary
    cd06183
    Location:83291
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1352
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  21. XM_036164017.1XP_036019910.1  NADH-cytochrome b5 reductase-like isoform X17

    Related
    ENSMUSP00000030364.7, ENSMUST00000030364.13
    Conserved Domains (2) summary
    cd06183
    Location:83281
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    pfam09791
    Location:1352
    Oxidored-like; Oxidoreductase-like protein, N-terminal
  22. XM_006502962.5XP_006503025.1  NADH-cytochrome b5 reductase-like isoform X15

    See identical proteins and their annotated locations for XP_006503025.1

    Conserved Domains (1) summary
    cd06183
    Location:2206
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
  23. XM_011240484.4XP_011238786.1  NADH-cytochrome b5 reductase-like isoform X15

    See identical proteins and their annotated locations for XP_011238786.1

    Conserved Domains (1) summary
    cd06183
    Location:2206
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

RNA

  1. XR_004941866.1 RNA Sequence

  2. XR_376304.5 RNA Sequence

  3. XR_004941865.1 RNA Sequence

  4. XR_004941867.1 RNA Sequence

  5. XR_003954908.2 RNA Sequence