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ZSWIM8 zinc finger SWIM-type containing 8 [ Homo sapiens (human) ]

Gene ID: 23053, updated on 9-Feb-2020

Summary

Official Symbol
ZSWIM8provided by HGNC
Official Full Name
zinc finger SWIM-type containing 8provided by HGNC
Primary source
HGNC:HGNC:23528
See related
Ensembl:ENSG00000214655
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0913
Expression
Ubiquitous expression in testis (RPKM 21.6), spleen (RPKM 16.0) and 25 other tissues See more
Orthologs

Genomic context

See ZSWIM8 in Genome Data Viewer
Location:
10q22.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (73785577..73801798)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75545334..75561556)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984243 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene calcium/calmodulin dependent protein kinase II gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34302, KIAA0913, MGC168869, MGC168870, 4832404P21Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger SWIM domain-containing protein 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242487.2NP_001229416.1  zinc finger SWIM domain-containing protein 8 isoform 2

    See identical proteins and their annotated locations for NP_001229416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AB020720, AC022400, BC040726, BC151206
    Consensus CDS
    CCDS60560.1
    UniProtKB/Swiss-Prot
    A7E2V4
    Related
    ENSP00000474748.1, ENST00000605216.5
    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger
  2. NM_001242488.2NP_001229417.1  zinc finger SWIM domain-containing protein 8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the 3' coding region with the latter resulting in a frameshift, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB020720, AC022400, BC040726, BC111006, BC151206
    UniProtKB/Swiss-Prot
    A7E2V4
    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger
  3. NM_001367799.1NP_001354728.1  zinc finger SWIM domain-containing protein 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC022400
    Related
    ENSP00000474944.1, ENST00000604729.5
  4. NM_015037.3NP_055852.2  zinc finger SWIM domain-containing protein 8 isoform 1

    See identical proteins and their annotated locations for NP_055852.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1).
    Source sequence(s)
    AB020720, AK023742, BC040726, BC151206
    Consensus CDS
    CCDS44440.1
    UniProtKB/Swiss-Prot
    A7E2V4
    Related
    ENSP00000381693.2, ENST00000398706.6
    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger

RNA

  1. NR_160292.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022400

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    73785577..73801798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269648.2XP_005269705.1  zinc finger SWIM domain-containing protein 8 isoform X1

    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger
  2. XM_017015978.1XP_016871467.1  zinc finger SWIM domain-containing protein 8 isoform X2

  3. XM_006717725.3XP_006717788.1  zinc finger SWIM domain-containing protein 8 isoform X4

    UniProtKB/Swiss-Prot
    A7E2V4
    Related
    ENSP00000474043.1, ENST00000603114.5
    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger
  4. XM_011539544.1XP_011537846.1  zinc finger SWIM domain-containing protein 8 isoform X6

    Related
    ENSP00000387828.2, ENST00000433366.6
    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger
  5. XM_005269655.3XP_005269712.1  zinc finger SWIM domain-containing protein 8 isoform X5

    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger

RNA

  1. XR_001747066.1 RNA Sequence

  2. XR_945632.2 RNA Sequence

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