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ZSWIM8 zinc finger SWIM-type containing 8 [ Homo sapiens (human) ]

Gene ID: 23053, updated on 6-Sep-2022

Summary

Official Symbol
ZSWIM8provided by HGNC
Official Full Name
zinc finger SWIM-type containing 8provided by HGNC
Primary source
HGNC:HGNC:23528
See related
Ensembl:ENSG00000214655 MIM:619213; AllianceGenome:HGNC:23528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0913
Summary
Enables ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of miRNA catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 21.6), spleen (RPKM 16.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZSWIM8 in Genome Data Viewer
Location:
10q22.2
Exon count:
28
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73785606..73801793)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74657006..74673193)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75545364..75561551)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984243 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene calcium/calmodulin dependent protein kinase II gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34302, KIAA0913, MGC168869, MGC168870, 4832404P21Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger SWIM domain-containing protein 8

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242487.2NP_001229416.1  zinc finger SWIM domain-containing protein 8 isoform 2

    See identical proteins and their annotated locations for NP_001229416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AB020720, AC022400, BC040726, BC151206
    Consensus CDS
    CCDS60560.1
    UniProtKB/Swiss-Prot
    A7E2V4, Q9H8F3
    Related
    ENSP00000474748.1, ENST00000605216.5
    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger
  2. NM_001242488.2NP_001229417.1  zinc finger SWIM domain-containing protein 8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the 3' coding region with the latter resulting in a frameshift, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB020720, AC022400, BC040726, BC111006, BC151206
    UniProtKB/Swiss-Prot
    A7E2V4
    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger
  3. NM_001367799.1NP_001354728.1  zinc finger SWIM domain-containing protein 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC022400
    UniProtKB/TrEMBL
    S4R410
    Related
    ENSP00000474944.1, ENST00000604729.6
  4. NM_015037.4NP_055852.2  zinc finger SWIM domain-containing protein 8 isoform 1

    See identical proteins and their annotated locations for NP_055852.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1).
    Source sequence(s)
    AB020720, AC022400, AK023742, BC040726, BC151206
    Consensus CDS
    CCDS44440.1
    UniProtKB/Swiss-Prot
    A7E2V4
    Related
    ENSP00000381693.2, ENST00000398706.6
    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger

RNA

  1. NR_160292.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022400

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73785606..73801793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269648.3XP_005269705.1  zinc finger SWIM domain-containing protein 8 isoform X1

    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger
  2. XM_017015978.2XP_016871467.1  zinc finger SWIM domain-containing protein 8 isoform X2

  3. XM_006717725.4XP_006717788.1  zinc finger SWIM domain-containing protein 8 isoform X11

    UniProtKB/Swiss-Prot
    A7E2V4
    Related
    ENSP00000474043.1, ENST00000603114.5
    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger
  4. XM_047424867.1XP_047280823.1  zinc finger SWIM domain-containing protein 8 isoform X10

  5. XM_047424860.1XP_047280816.1  zinc finger SWIM domain-containing protein 8 isoform X3

  6. XM_047424868.1XP_047280824.1  zinc finger SWIM domain-containing protein 8 isoform X12

  7. XM_047424861.1XP_047280817.1  zinc finger SWIM domain-containing protein 8 isoform X4

  8. XM_047424869.1XP_047280825.1  zinc finger SWIM domain-containing protein 8 isoform X13

  9. XM_047424870.1XP_047280826.1  zinc finger SWIM domain-containing protein 8 isoform X14

  10. XM_047424862.1XP_047280818.1  zinc finger SWIM domain-containing protein 8 isoform X5

  11. XM_005269655.4XP_005269712.1  zinc finger SWIM domain-containing protein 8 isoform X16

    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger
  12. XM_047424865.1XP_047280821.1  zinc finger SWIM domain-containing protein 8 isoform X8

  13. XM_047424871.1XP_047280827.1  zinc finger SWIM domain-containing protein 8 isoform X15

  14. XM_047424863.1XP_047280819.1  zinc finger SWIM domain-containing protein 8 isoform X6

  15. XM_047424872.1XP_047280828.1  zinc finger SWIM domain-containing protein 8 isoform X17

  16. XM_047424866.1XP_047280822.1  zinc finger SWIM domain-containing protein 8 isoform X9

  17. XM_047424864.1XP_047280820.1  zinc finger SWIM domain-containing protein 8 isoform X7

  18. XM_011539544.2XP_011537846.1  zinc finger SWIM domain-containing protein 8 isoform X19

    Related
    ENSP00000387828.2, ENST00000433366.6
    Conserved Domains (1) summary
    cl19527
    Location:131263
    SWIM; SWIM zinc finger
  19. XM_047424874.1XP_047280830.1  zinc finger SWIM domain-containing protein 8 isoform X20

  20. XM_047424875.1XP_047280831.1  zinc finger SWIM domain-containing protein 8 isoform X21

  21. XM_047424873.1XP_047280829.1  zinc finger SWIM domain-containing protein 8 isoform X18

    Related
    ENSP00000474766.1, ENST00000603187.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74657006..74673193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)