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ZHX3 zinc fingers and homeoboxes 3 [ Homo sapiens (human) ]

Gene ID: 23051, updated on 26-Oct-2022

Summary

Official Symbol
ZHX3provided by HGNC
Official Full Name
zinc fingers and homeoboxes 3provided by HGNC
Primary source
HGNC:HGNC:15935
See related
Ensembl:ENSG00000174306 MIM:609598; AllianceGenome:HGNC:15935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIX1
Summary
This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 8.0), brain (RPKM 7.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZHX3 in Genome Data Viewer
Location:
20q12
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (41178455..41317731, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (42910141..43049531, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (39807095..39946371, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PLCG1 antisense RNA 1 Neighboring gene translation initiation factor IF-2-like Neighboring gene phospholipase C gamma 1 Neighboring gene microRNA 6871 Neighboring gene ribosomal protein L23a pseudogene 81 Neighboring gene RNA, 7SL, cytoplasmic 615, pseudogene Neighboring gene acireductone dioxygenase 1 pseudogene 1 Neighboring gene lipin 3 Neighboring gene elastin microfibril interfacer 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0395

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc fingers and homeoboxes protein 3
Names
triple homeobox 1
triple homeobox protein 1
zinc finger and homeodomain protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046923.1 RefSeqGene

    Range
    4888..144164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001384315.1NP_001371244.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    Q6NUJ7
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  2. NM_001384316.1NP_001371245.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    Q6NUJ7
    Related
    ENSP00000452965.1, ENST00000559234.5
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  3. NM_001384317.1NP_001371246.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    Q6NUJ7
    Related
    ENSP00000506788.1, ENST00000683867.1
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  4. NM_001384318.1NP_001371247.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    Q6NUJ7
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  5. NM_001384319.1NP_001371248.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    Q6NUJ7
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  6. NM_001384320.1NP_001371249.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    Q6NUJ7
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  7. NM_001384321.1NP_001371250.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    Q6NUJ7
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  8. NM_001384322.1NP_001371251.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    Q6NUJ7
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  9. NM_001384323.1NP_001371252.1  zinc fingers and homeoboxes protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    Q6NUJ7
    Related
    ENSP00000454006.1, ENST00000560361.5
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  10. NM_001384324.1NP_001371253.1  zinc fingers and homeoboxes protein 3 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL022394, AL031257
    Consensus CDS
    CCDS93040.1
    Related
    ENSP00000443783.2, ENST00000544979.6
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850891
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  11. NM_001384325.1NP_001371254.1  zinc fingers and homeoboxes protein 3 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL022394, AL031257
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  12. NM_015035.4NP_055850.1  zinc fingers and homeoboxes protein 3 isoform a

    See identical proteins and their annotated locations for NP_055850.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AB081948, AL022394, AL031257, BI458686
    Consensus CDS
    CCDS13315.1
    UniProtKB/Swiss-Prot
    Q6NUJ7, Q9H4I2
    Related
    ENSP00000415498.3, ENST00000432768.6
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    41178455..41317731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440045.1XP_047296001.1  zinc fingers and homeoboxes protein 3 isoform X3

    UniProtKB/Swiss-Prot
    Q6NUJ7
  2. XM_005260341.5XP_005260398.1  zinc fingers and homeoboxes protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q9H4I2
    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850891
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  3. XM_047440044.1XP_047296000.1  zinc fingers and homeoboxes protein 3 isoform X2

  4. XM_047440046.1XP_047296002.1  zinc fingers and homeoboxes protein 3 isoform X3

    UniProtKB/Swiss-Prot
    Q6NUJ7
  5. XM_047440036.1XP_047295992.1  zinc fingers and homeoboxes protein 3 isoform X1

  6. XM_047440037.1XP_047295993.1  zinc fingers and homeoboxes protein 3 isoform X1

  7. XM_047440039.1XP_047295995.1  zinc fingers and homeoboxes protein 3 isoform X1

  8. XM_011528704.4XP_011527006.1  zinc fingers and homeoboxes protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011527006.1

    Conserved Domains (4) summary
    smart00389
    Location:621666
    HOX; Homeodomain
    cd00086
    Location:500553
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:850892
    Homez; Homeodomain leucine-zipper encoding, Homez
    pfam18387
    Location:105157
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain
  9. XM_047440040.1XP_047295996.1  zinc fingers and homeoboxes protein 3 isoform X1

  10. XM_047440038.1XP_047295994.1  zinc fingers and homeoboxes protein 3 isoform X1

  11. XM_047440041.1XP_047295997.1  zinc fingers and homeoboxes protein 3 isoform X1

  12. XM_047440042.1XP_047295998.1  zinc fingers and homeoboxes protein 3 isoform X1

  13. XM_047440043.1XP_047295999.1  zinc fingers and homeoboxes protein 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    42910141..43049531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)