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FNBP1 formin binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23048, updated on 7-Dec-2018

Summary

Official Symbol
FNBP1provided by HGNC
Official Full Name
formin binding protein 1provided by HGNC
Primary source
HGNC:HGNC:17069
See related
Ensembl:ENSG00000187239 MIM:606191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP17
Summary
The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 19.9), spleen (RPKM 17.6) and 24 other tissues See more
Orthologs

Genomic context

See FNBP1 in Genome Data Viewer
Location:
9q34.11
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (129887187..130053846, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (132649458..132805473, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 78 Neighboring gene ubiquitin specific peptidase 20 Neighboring gene microRNA 6855 Neighboring gene G protein-coupled receptor 107 Neighboring gene GPR107 adjacent cis regulating lncRNA Neighboring gene neuronal calcium sensor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0554, MGC126804

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
formin-binding protein 1
Names
formin-binding protein 17

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033946.1 RefSeqGene

    Range
    5001..161008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363755.1NP_001350684.1  formin-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AA848014, AK023681, AL158207, DA043485
    Consensus CDS
    CCDS87699.1
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:378454
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:524579
    SH3; Src Homology 3 domain superfamily
  2. NM_015033.3NP_055848.1  formin-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055848.1

    Status: REVIEWED

    Source sequence(s)
    AB011126, AL158207, AW575478, CK005680
    Consensus CDS
    CCDS48040.1
    UniProtKB/Swiss-Prot
    Q96RU3
    Related
    ENSP00000413625.1, ENST00000446176.6
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:407483
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:553608
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    129887187..130053846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251834.2XP_005251891.1  formin-binding protein 1 isoform X30

    See identical proteins and their annotated locations for XP_005251891.1

    UniProtKB/TrEMBL
    B7ZL14
    Related
    ENSP00000389117.3, ENST00000443566.6
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:341417
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:487542
    SH3; Src Homology 3 domain superfamily
  2. XM_017014494.1XP_016869983.1  formin-binding protein 1 isoform X27

  3. XM_017014491.1XP_016869980.1  formin-binding protein 1 isoform X22

  4. XM_017014490.1XP_016869979.1  formin-binding protein 1 isoform X21

  5. XM_005251826.2XP_005251883.1  formin-binding protein 1 isoform X16

    See identical proteins and their annotated locations for XP_005251883.1

    UniProtKB/TrEMBL
    B7ZL13
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:397473
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:543598
    SH3; Src Homology 3 domain superfamily
  6. XM_005251824.2XP_005251881.1  formin-binding protein 1 isoform X13

    See identical proteins and their annotated locations for XP_005251881.1

    UniProtKB/Swiss-Prot
    Q96RU3
    Related
    ENSP00000407548.2, ENST00000420781.5
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:402478
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:548603
    SH3; Src Homology 3 domain superfamily
  7. XM_011518402.1XP_011516704.1  formin-binding protein 1 isoform X4

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:581636
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
  8. XM_011518401.1XP_011516703.1  formin-binding protein 1 isoform X3

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:582637
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
  9. XM_017014492.2XP_016869981.1  formin-binding protein 1 isoform X24

  10. XM_005251833.3XP_005251890.1  formin-binding protein 1 isoform X29

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:341417
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:487542
    SH3; Src Homology 3 domain superfamily
  11. XM_005251832.3XP_005251889.1  formin-binding protein 1 isoform X28

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:341417
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:488543
    SH3; Src Homology 3 domain superfamily
  12. XM_017014493.2XP_016869982.1  formin-binding protein 1 isoform X26

  13. XM_005251831.3XP_005251888.1  formin-binding protein 1 isoform X25

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:346422
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:493548
    SH3; Src Homology 3 domain superfamily
  14. XM_005251830.3XP_005251887.1  formin-binding protein 1 isoform X23

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:373449
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:520575
    SH3; Src Homology 3 domain superfamily
  15. XM_005251829.3XP_005251886.1  formin-binding protein 1 isoform X20

    UniProtKB/Swiss-Prot
    Q96RU3
    Related
    ENSP00000347907.3, ENST00000355681.3
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:378454
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:524579
    SH3; Src Homology 3 domain superfamily
  16. XM_017014489.2XP_016869978.1  formin-binding protein 1 isoform X19

  17. XM_017014487.2XP_016869976.1  formin-binding protein 1 isoform X10

  18. XM_006717016.3XP_006717079.1  formin-binding protein 1 isoform X9

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:406482
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:553608
    SH3; Src Homology 3 domain superfamily
  19. XM_005251828.3XP_005251885.1  formin-binding protein 1 isoform X18

    Related
    ENSP00000415602.2, ENST00000449089.6
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:392468
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:538593
    SH3; Src Homology 3 domain superfamily
  20. XM_005251827.3XP_005251884.1  formin-binding protein 1 isoform X17

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:392468
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:539594
    SH3; Src Homology 3 domain superfamily
  21. XM_005251825.3XP_005251882.1  formin-binding protein 1 isoform X15

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:397473
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:543598
    SH3; Src Homology 3 domain superfamily
  22. XM_017014488.2XP_016869977.1  formin-binding protein 1 isoform X14

  23. XM_024447457.1XP_024303225.1  formin-binding protein 1 isoform X6

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:425501
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:571626
    SH3; Src Homology 3 domain superfamily
  24. XM_005251815.3XP_005251872.1  formin-binding protein 1 isoform X5

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:425501
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:572627
    SH3; Src Homology 3 domain superfamily
  25. XM_005251823.3XP_005251880.1  formin-binding protein 1 isoform X12

    UniProtKB/Swiss-Prot
    Q96RU3
    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:402478
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:548603
    SH3; Src Homology 3 domain superfamily
  26. XM_005251822.3XP_005251879.1  formin-binding protein 1 isoform X11

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:402478
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:549604
    SH3; Src Homology 3 domain superfamily
  27. XM_005251821.3XP_005251878.1  formin-binding protein 1 isoform X8

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:407483
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:553608
    SH3; Src Homology 3 domain superfamily
  28. XM_005251820.3XP_005251877.1  formin-binding protein 1 isoform X7

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:407483
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:554609
    SH3; Src Homology 3 domain superfamily
  29. XM_011518400.3XP_011516702.1  formin-binding protein 1 isoform X2

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:581636
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
  30. XM_011518399.3XP_011516701.1  formin-binding protein 1 isoform X1

    Conserved Domains (3) summary
    cd07676
    Location:5257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:582637
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
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