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MON2 MON2 homolog, regulator of endosome-to-Golgi trafficking [ Homo sapiens (human) ]

Gene ID: 23041, updated on 4-Nov-2018

Summary

Official Symbol
MON2provided by HGNC
Official Full Name
MON2 homolog, regulator of endosome-to-Golgi traffickingprovided by HGNC
Primary source
HGNC:HGNC:29177
See related
Ensembl:ENSG00000061987 MIM:616822; Vega:OTTHUMG00000169992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 6.3), ovary (RPKM 5.3) and 25 other tissues See more
Orthologs

Genomic context

See MON2 in Genome Data Viewer
Location:
12q14.1
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (62466817..62598956)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (62860597..62991363)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene microRNA 6125 Neighboring gene ubiquitin specific peptidase 15 Neighboring gene RNA, U6 small nuclear 595, pseudogene Neighboring gene RNA, U6 small nuclear 399, pseudogene Neighboring gene long intergenic non-protein coding RNA 1465 Neighboring gene microRNA let-7i

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The CA domain and the p6 domain of HIV-1 Gag and the N-terminal region (residues 1-410) of MON2 are required for the interaction between Gag and MON2 PubMed
gag VPS18 and MON2 proteins are required for proper HIV-1 Gag localization to plasma membrane and the efficient production of infectious virions in human cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1040, MGC35493

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi to endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
protein MON2 homolog
Names
MON2 regulator of endosome-to-Golgi trafficking

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278469.2NP_001265398.1  protein MON2 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' end that includes an in-frame stop codon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC026115, AL833066, BC151241, BU739072, DA125763
    Consensus CDS
    CCDS61177.1
    UniProtKB/Swiss-Prot
    Q7Z3U7
    Related
    ENSP00000447407.1, OTTHUMP00000242611, ENST00000546600.5
    Conserved Domains (4) summary
    pfam09324
    Location:872931
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:212379
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:9341663
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9183
    DCB; Dimerization and cyclophilin-binding domain of Mon2
  2. NM_001278470.1NP_001265399.1  protein MON2 homolog isoform 3

    See identical proteins and their annotated locations for NP_001265399.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC026115, BC136621, DA125763
    Consensus CDS
    CCDS61178.1
    UniProtKB/Swiss-Prot
    Q7Z3U7
    Related
    ENSP00000377249.2, OTTHUMP00000242622, ENST00000393629.6, OTTHUMT00000406865
    Conserved Domains (4) summary
    pfam09324
    Location:872931
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:212379
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:9341702
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9183
    DCB; Dimerization and cyclophilin-binding domain of Mon2
  3. NM_001278471.1NP_001265400.1  protein MON2 homolog isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site at the 3' end of an exon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC026115, BC144309, DA125763
    Consensus CDS
    CCDS61175.1
    UniProtKB/TrEMBL
    B7ZM73
    Related
    ENSP00000449215.1, OTTHUMP00000242613, ENST00000552738.5, OTTHUMT00000406847
    Conserved Domains (4) summary
    pfam09324
    Location:849908
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:212379
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:9111679
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9183
    DCB; Dimerization and cyclophilin-binding domain of Mon2
  4. NM_001278472.1NP_001265401.1  protein MON2 homolog isoform 5

    See identical proteins and their annotated locations for NP_001265401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC026115, BC144324, DA125763
    Conserved Domains (4) summary
    pfam09324
    Location:800859
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:140307
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:8621636
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:1111
    DCB; Dimerization and cyclophilin-binding domain of Mon2
  5. NM_015026.2NP_055841.2  protein MON2 homolog isoform 1

    See identical proteins and their annotated locations for NP_055841.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB017814, AC026115, AL834320, DA125763
    Consensus CDS
    CCDS31849.1
    UniProtKB/Swiss-Prot
    Q7Z3U7
    Related
    ENSP00000377250.4, OTTHUMP00000242574, ENST00000393630.7, OTTHUMT00000406767
    Conserved Domains (4) summary
    pfam09324
    Location:872931
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:212379
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:9341708
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9183
    DCB; Dimerization and cyclophilin-binding domain of Mon2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    62466817..62598956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019041.1XP_016874530.1  protein MON2 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q7Z3U7
    UniProtKB/TrEMBL
    A0A286YFF8
    Related
    ENSP00000493462.1, ENST00000641654.1
    Conserved Domains (4) summary
    pfam09324
    Location:873932
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:212379
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:9351709
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9183
    DCB; Dimerization and cyclophilin-binding domain of Mon2
  2. XM_017019042.1XP_016874531.1  protein MON2 homolog isoform X2

  3. XM_017019043.1XP_016874532.1  protein MON2 homolog isoform X3

  4. XM_017019044.1XP_016874533.1  protein MON2 homolog isoform X3

  5. XM_017019045.1XP_016874534.1  protein MON2 homolog isoform X3

  6. XM_017019046.1XP_016874535.1  protein MON2 homolog isoform X4

RNA

  1. XR_001748628.1 RNA Sequence

  2. XR_001748629.1 RNA Sequence

  3. XR_001748627.1 RNA Sequence

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