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ZNF292 zinc finger protein 292 [ Homo sapiens (human) ]

Gene ID: 23036, updated on 1-Jun-2020

Summary

Official Symbol
ZNF292provided by HGNC
Official Full Name
zinc finger protein 292provided by HGNC
Primary source
HGNC:HGNC:18410
See related
Ensembl:ENSG00000188994 MIM:616213
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZN-16; Zn-15; ZFP292; Nbla00365; bA393I2.3
Summary
This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in bone marrow (RPKM 4.8), ovary (RPKM 3.8) and 25 other tissues See more
Orthologs

Genomic context

See ZNF292 in Genome Data Viewer
Location:
6q14.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (87155565..87265943)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (87865269..87973926)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glycoprotein hormones, alpha polypeptide Neighboring gene reticulocalbin 1 pseudogene 1 Neighboring gene RNA polymerase I subunit F pseudogene Neighboring gene gap junction protein beta 7 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 10 Neighboring gene tigger transposable element derived 6 pseudogene Neighboring gene small integral membrane protein 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 292 (ZNF292) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human zinc finger protein 292 (ZNF292) at amino acid residues 1770-1771 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13564, FLJ41479, KIAA0530

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 292
Names
16 zinc-finger domain protein
putative protein product of Nbla00365

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054887.1 RefSeqGene

    Range
    5015..115393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351444.2NP_001338373.1  zinc finger protein 292 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL139274, BX112525
    Conserved Domains (1) summary
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_015021.3NP_055836.1  zinc finger protein 292 isoform 1

    See identical proteins and their annotated locations for NP_055836.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB011102, AK123473, AK127835, AL139274, BC016386, BC063594, BX112525, BX537746, DA329523
    Consensus CDS
    CCDS47457.1
    UniProtKB/Swiss-Prot
    O60281
    Related
    ENSP00000358590.3, ENST00000369577.8
    Conserved Domains (1) summary
    sd00017
    Location:724744
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    87155565..87265943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535625.2XP_011533927.1  zinc finger protein 292 isoform X2

    Conserved Domains (1) summary
    sd00017
    Location:402422
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_017010578.2XP_016866067.1  zinc finger protein 292 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_017010584.2XP_016866073.1  zinc finger protein 292 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_017010576.1XP_016866065.1  zinc finger protein 292 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_017010580.1XP_016866069.1  zinc finger protein 292 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_005248697.4XP_005248754.1  zinc finger protein 292 isoform X1

    See identical proteins and their annotated locations for XP_005248754.1

    Conserved Domains (1) summary
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_017010577.1XP_016866066.1  zinc finger protein 292 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_017010582.1XP_016866071.1  zinc finger protein 292 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_017010579.1XP_016866068.1  zinc finger protein 292 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_017010583.1XP_016866072.1  zinc finger protein 292 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
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