U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DOP1A DOP1 leucine zipper like protein A [ Homo sapiens (human) ]

Gene ID: 23033, updated on 6-Nov-2022

Summary

Official Symbol
DOP1Aprovided by HGNC
Official Full Name
DOP1 leucine zipper like protein Aprovided by HGNC
Primary source
HGNC:HGNC:21194
See related
Ensembl:ENSG00000083097 MIM:616823; AllianceGenome:HGNC:21194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOP1; DOPEY1; KIAA1117; dJ202D23.2
Summary
Predicted to be involved in Golgi to endosome transport and endoplasmic reticulum organization. Predicted to be located in Golgi membrane. Predicted to be active in endosome and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 7.6), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DOP1A in Genome Data Viewer
Location:
6q14.1
Exon count:
46
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (83067671..83171350)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (84290676..84394587)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83777390..83881069)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377877 Neighboring gene ubiquitin protein ligase E3D Neighboring gene leucine aminopeptidase 3 pseudogene 1 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene malic enzyme 1

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35610

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Golgi to endosome transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein dopey-1
Names
dopey family member 1
homolog of yeast DOP1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199942.2NP_001186871.1  protein dopey-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and has an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform b) is longer compared to isoform a.
    Source sequence(s)
    AL121716, AL139333
    Consensus CDS
    CCDS64467.1
    UniProtKB/TrEMBL
    F6U2K4, Q5TA12
    Related
    ENSP00000237163.6, ENST00000237163.9
    Conserved Domains (2) summary
    pfam04118
    Location:13295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20822318
    Dopey_N; Dopey, N-terminal
  2. NM_001385856.1NP_001372785.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (2) summary
    pfam04118
    Location:13297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20812317
    Dopey_N; Dopey, N-terminal
  3. NM_001385857.1NP_001372786.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (2) summary
    pfam04118
    Location:13297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20812317
    Dopey_N; Dopey, N-terminal
  4. NM_001385858.1NP_001372787.1  protein dopey-1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (1) summary
    cl04407
    Location:1146
    Dopey_N; Dopey, N-terminal
  5. NM_001385859.1NP_001372788.1  protein dopey-1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (1) summary
    cl04407
    Location:18161976
    Dopey_N; Dopey, N-terminal
  6. NM_001385860.1NP_001372789.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (2) summary
    pfam04118
    Location:13297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20812317
    Dopey_N; Dopey, N-terminal
  7. NM_001385861.1NP_001372790.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (2) summary
    pfam04118
    Location:13297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20812317
    Dopey_N; Dopey, N-terminal
  8. NM_001385863.1NP_001372792.1  protein dopey-1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Consensus CDS
    CCDS64467.1
    UniProtKB/TrEMBL
    F6U2K4
    Conserved Domains (2) summary
    pfam04118
    Location:13295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20822318
    Dopey_N; Dopey, N-terminal
  9. NM_001385864.1NP_001372793.1  protein dopey-1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (1) summary
    cl04407
    Location:15791815
    Dopey_N; Dopey, N-terminal
  10. NM_001385865.1NP_001372794.1  protein dopey-1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (2) summary
    pfam04118
    Location:13295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20822318
    Dopey_N; Dopey, N-terminal
  11. NM_015018.4NP_055833.2  protein dopey-1 isoform a

    See identical proteins and their annotated locations for NP_055833.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform a).
    Source sequence(s)
    AL121716, AL139333
    Consensus CDS
    CCDS4996.1
    UniProtKB/Swiss-Prot
    Q5JWR5, Q9Y414
    UniProtKB/TrEMBL
    B2RWN9
    Related
    ENSP00000195654.3, ENST00000349129.7
    Conserved Domains (2) summary
    pfam04118
    Location:13299
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20912327
    Dopey_N; Dopey, N-terminal

RNA

  1. NR_169790.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
  2. NR_169791.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    83067671..83171350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010559.2XP_016866048.1  protein dopey-1 isoform X1

  2. XM_017010564.2XP_016866053.1  protein dopey-1 isoform X5

    UniProtKB/Swiss-Prot
    Q5JWR5, Q9Y414
    Conserved Domains (2) summary
    pfam04118
    Location:13299
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20912327
    Dopey_N; Dopey, N-terminal
  3. XM_017010572.2XP_016866061.1  protein dopey-1 isoform X11

  4. XM_047418447.1XP_047274403.1  protein dopey-1 isoform X15

  5. XM_047418448.1XP_047274404.1  protein dopey-1 isoform X15

  6. XM_017010571.2XP_016866060.1  protein dopey-1 isoform X9

  7. XM_047418442.1XP_047274398.1  protein dopey-1 isoform X12

  8. XM_047418443.1XP_047274399.1  protein dopey-1 isoform X12

  9. XM_047418451.1XP_047274407.1  protein dopey-1 isoform X18

  10. XM_011535619.3XP_011533921.1  protein dopey-1 isoform X3

    See identical proteins and their annotated locations for XP_011533921.1

    Conserved Domains (2) summary
    pfam04118
    Location:13299
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20812317
    Dopey_N; Dopey, N-terminal
  11. XM_047418434.1XP_047274390.1  protein dopey-1 isoform X7

  12. XM_017010561.2XP_016866050.1  protein dopey-1 isoform X2

    UniProtKB/TrEMBL
    F6U2K4, Q5TA12
    Conserved Domains (2) summary
    pfam04118
    Location:13295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20822318
    Dopey_N; Dopey, N-terminal
  13. XM_017010570.2XP_016866059.1  protein dopey-1 isoform X8

  14. XM_047418440.1XP_047274396.1  protein dopey-1 isoform X10

  15. XM_047418445.1XP_047274401.1  protein dopey-1 isoform X13

  16. XM_047418450.1XP_047274406.1  protein dopey-1 isoform X17

  17. XM_017010560.3XP_016866049.1  protein dopey-1 isoform X1

  18. XM_047418430.1XP_047274386.1  protein dopey-1 isoform X3

  19. XM_047418435.1XP_047274391.1  protein dopey-1 isoform X7

  20. XM_047418449.1XP_047274405.1  protein dopey-1 isoform X16

  21. XM_047418446.1XP_047274402.1  protein dopey-1 isoform X14

  22. XM_017010562.3XP_016866051.1  protein dopey-1 isoform X2

    UniProtKB/TrEMBL
    F6U2K4, Q5TA12
    Conserved Domains (2) summary
    pfam04118
    Location:13295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20822318
    Dopey_N; Dopey, N-terminal
  23. XM_047418433.1XP_047274389.1  protein dopey-1 isoform X6

  24. XM_047418432.1XP_047274388.1  protein dopey-1 isoform X4

  25. XM_047418438.1XP_047274394.1  protein dopey-1 isoform X8

  26. XM_047418439.1XP_047274395.1  protein dopey-1 isoform X10

  27. XM_047418444.1XP_047274400.1  protein dopey-1 isoform X13

  28. XM_047418452.1XP_047274408.1  protein dopey-1 isoform X19

  29. XM_047418453.1XP_047274409.1  protein dopey-1 isoform X20

  30. XM_047418455.1XP_047274411.1  protein dopey-1 isoform X24

  31. XM_017010573.1XP_016866062.1  protein dopey-1 isoform X21

  32. XM_017010574.1XP_016866063.1  protein dopey-1 isoform X22

  33. XM_047418454.1XP_047274410.1  protein dopey-1 isoform X23

  34. XM_047418428.1XP_047274384.1  protein dopey-1 isoform X1

  35. XM_047418431.1XP_047274387.1  protein dopey-1 isoform X3

  36. XM_047418436.1XP_047274392.1  protein dopey-1 isoform X7

  37. XM_047418441.1XP_047274397.1  protein dopey-1 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    84290676..84394587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)