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DOP1A DOP1 leucine zipper like protein A [ Homo sapiens (human) ]

Gene ID: 23033, updated on 4-Jul-2021

Summary

Official Symbol
DOP1Aprovided by HGNC
Official Full Name
DOP1 leucine zipper like protein Aprovided by HGNC
Primary source
HGNC:HGNC:21194
See related
Ensembl:ENSG00000083097 MIM:616823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOP1; DOPEY1; KIAA1117; dJ202D23.2
Expression
Ubiquitous expression in testis (RPKM 7.6), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See DOP1A in Genome Data Viewer
Location:
6q14.1
Exon count:
46
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (83067671..83171351)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83777390..83881069)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377877 Neighboring gene ubiquitin protein ligase E3D Neighboring gene leucine aminopeptidase 3 pseudogene 1 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene malic enzyme 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35610

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Golgi to endosome transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi-associated vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein dopey-1
Names
dopey family member 1
homolog of yeast DOP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199942.2NP_001186871.1  protein dopey-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and has an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform b) is longer compared to isoform a.
    Source sequence(s)
    AL121716, AL139333
    Consensus CDS
    CCDS64467.1
    UniProtKB/TrEMBL
    Q5TA12
    Related
    ENSP00000237163.6, ENST00000237163.9
    Conserved Domains (2) summary
    pfam04118
    Location:13295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20822318
    Dopey_N; Dopey, N-terminal
  2. NM_001385856.1NP_001372785.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (2) summary
    pfam04118
    Location:13297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20812317
    Dopey_N; Dopey, N-terminal
  3. NM_001385857.1NP_001372786.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (2) summary
    pfam04118
    Location:13297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20812317
    Dopey_N; Dopey, N-terminal
  4. NM_001385858.1NP_001372787.1  protein dopey-1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (1) summary
    cl04407
    Location:1146
    Dopey_N; Dopey, N-terminal
  5. NM_001385859.1NP_001372788.1  protein dopey-1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (1) summary
    cl04407
    Location:18161976
    Dopey_N; Dopey, N-terminal
  6. NM_001385860.1NP_001372789.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (2) summary
    pfam04118
    Location:13297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20812317
    Dopey_N; Dopey, N-terminal
  7. NM_001385861.1NP_001372790.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (2) summary
    pfam04118
    Location:13297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20812317
    Dopey_N; Dopey, N-terminal
  8. NM_001385863.1NP_001372792.1  protein dopey-1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (2) summary
    pfam04118
    Location:13295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20822318
    Dopey_N; Dopey, N-terminal
  9. NM_001385864.1NP_001372793.1  protein dopey-1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (1) summary
    cl04407
    Location:15791815
    Dopey_N; Dopey, N-terminal
  10. NM_001385865.1NP_001372794.1  protein dopey-1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (2) summary
    pfam04118
    Location:13295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20822318
    Dopey_N; Dopey, N-terminal
  11. NM_015018.4NP_055833.2  protein dopey-1 isoform a

    See identical proteins and their annotated locations for NP_055833.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform a).
    Source sequence(s)
    AL121716, AL139333
    Consensus CDS
    CCDS4996.1
    UniProtKB/Swiss-Prot
    Q5JWR5
    UniProtKB/TrEMBL
    B2RWN9
    Related
    ENSP00000195654.3, ENST00000349129.7
    Conserved Domains (2) summary
    pfam04118
    Location:13299
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20912327
    Dopey_N; Dopey, N-terminal

RNA

  1. NR_169790.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
  2. NR_169791.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    83067671..83171351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010559.1XP_016866048.1  protein dopey-1 isoform X1

  2. XM_017010572.1XP_016866061.1  protein dopey-1 isoform X9

  3. XM_017010571.1XP_016866060.1  protein dopey-1 isoform X8

  4. XM_011535619.2XP_011533921.1  protein dopey-1 isoform X3

    See identical proteins and their annotated locations for XP_011533921.1

    Conserved Domains (2) summary
    pfam04118
    Location:13299
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20812317
    Dopey_N; Dopey, N-terminal
  5. XM_017010570.1XP_016866059.1  protein dopey-1 isoform X7

  6. XM_017010560.2XP_016866049.1  protein dopey-1 isoform X1

  7. XM_017010562.2XP_016866051.1  protein dopey-1 isoform X2

    UniProtKB/TrEMBL
    Q5TA12
    Conserved Domains (2) summary
    pfam04118
    Location:13295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20822318
    Dopey_N; Dopey, N-terminal
  8. XM_017010573.1XP_016866062.1  protein dopey-1 isoform X10

  9. XM_017010574.1XP_016866063.1  protein dopey-1 isoform X11

  10. XM_017010561.1XP_016866050.1  protein dopey-1 isoform X2

    UniProtKB/TrEMBL
    Q5TA12
    Conserved Domains (2) summary
    pfam04118
    Location:13295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20822318
    Dopey_N; Dopey, N-terminal
  11. XM_017010564.1XP_016866053.1  protein dopey-1 isoform X4

    UniProtKB/Swiss-Prot
    Q5JWR5
    Conserved Domains (2) summary
    pfam04118
    Location:13299
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:20912327
    Dopey_N; Dopey, N-terminal
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