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USP33 ubiquitin specific peptidase 33 [ Homo sapiens (human) ]

Gene ID: 23032, updated on 4-Jul-2021

Summary

Official Symbol
USP33provided by HGNC
Official Full Name
ubiquitin specific peptidase 33provided by HGNC
Primary source
HGNC:HGNC:20059
See related
Ensembl:ENSG00000077254 MIM:615146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VDU1
Summary
This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Expression
Ubiquitous expression in fat (RPKM 19.0), brain (RPKM 15.9) and 25 other tissues See more
Orthologs
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Genomic context

See USP33 in Genome Data Viewer
Location:
1p31.1
Exon count:
27
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (77695987..77759852, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78161672..78225537, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger ZZ-type containing 3 Neighboring gene RNA, 5S ribosomal pseudogene 20 Neighboring gene RNA, 7SL, cytoplasmic 370, pseudogene Neighboring gene actin gamma 1 pseudogene 21 Neighboring gene RNA, 5S ribosomal pseudogene 21 Neighboring gene mitoguardin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1097, MGC16868

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thiol-dependent deubiquitinase IDA
Inferred from Direct Assay
more info
PubMed 
enables thiol-dependent deubiquitinase IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables thiol-dependent deubiquitinase TAS
Traceable Author Statement
more info
PubMed 
NOT enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
part_of VCB complex TAS
Traceable Author Statement
more info
PubMed 
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 33
Names
VHL-interacting deubiquitinating enzyme 1
deubiquitinating enzyme 33
pVHL-interacting deubiquitinating enzyme 1
ubiquitin thioesterase 33
ubiquitin thiolesterase 33
ubiquitin-specific-processing protease 33
NP_001364359.1
NP_001364360.1
NP_001364361.1
NP_001364362.1
NP_001364363.1
NP_001364364.1
NP_001364365.1
NP_001364366.1
NP_001364367.1
NP_001364368.1
NP_055832.3
NP_963918.1
NP_963920.1
XP_011539358.1
XP_016856218.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377430.1NP_001364359.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC114487
    Conserved Domains (4) summary
    smart00695
    Location:832916
    DUSP; Domain in ubiquitin-specific proteases
    COG5207
    Location:39285
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    pfam00443
    Location:185704
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl12116
    Location:726795
    DUSP; DUSP domain
  2. NM_001377431.1NP_001364360.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC114487
    Conserved Domains (4) summary
    smart00695
    Location:801885
    DUSP; Domain in ubiquitin-specific proteases
    COG5207
    Location:8254
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    pfam00443
    Location:154673
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl12116
    Location:695764
    DUSP; DUSP domain
  3. NM_001377432.1NP_001364361.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC114487
    Conserved Domains (3) summary
    COG5207
    Location:39285
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    pfam00443
    Location:185712
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl12116
    Location:734803
    DUSP; DUSP domain
  4. NM_001377433.1NP_001364362.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC114487
    Conserved Domains (3) summary
    smart00695
    Location:741825
    DUSP; Domain in ubiquitin-specific proteases
    COG5207
    Location:39285
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    pfam00443
    Location:185671
    UCH; Ubiquitin carboxyl-terminal hydrolase
  5. NM_001377434.1NP_001364363.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC114487
    Conserved Domains (3) summary
    COG5207
    Location:8254
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    pfam00443
    Location:154681
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl12116
    Location:703772
    DUSP; DUSP domain
  6. NM_001377435.1NP_001364364.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC114487
    Conserved Domains (3) summary
    smart00695
    Location:710794
    DUSP; Domain in ubiquitin-specific proteases
    COG5207
    Location:8254
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    pfam00443
    Location:154640
    UCH; Ubiquitin carboxyl-terminal hydrolase
  7. NM_001377436.1NP_001364365.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC114487
    Conserved Domains (3) summary
    COG5207
    Location:8254
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    pfam00443
    Location:154673
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl12116
    Location:695764
    DUSP; DUSP domain
  8. NM_001377437.1NP_001364366.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC114487
    Conserved Domains (3) summary
    smart00695
    Location:702786
    DUSP; Domain in ubiquitin-specific proteases
    COG5207
    Location:8254
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    pfam00443
    Location:154632
    UCH; Ubiquitin carboxyl-terminal hydrolase
  9. NM_001377438.1NP_001364367.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC114487
    Conserved Domains (3) summary
    smart00695
    Location:661745
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:294534
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl12116
    Location:555624
    DUSP; DUSP domain
  10. NM_001377439.1NP_001364368.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC114487
    Conserved Domains (3) summary
    smart00695
    Location:661745
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:294534
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl12116
    Location:555624
    DUSP; DUSP domain
  11. NM_015017.5NP_055832.3  ubiquitin carboxyl-terminal hydrolase 33 isoform 1

    See identical proteins and their annotated locations for NP_055832.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF383172, AF383173, AI569971, BC016663
    Consensus CDS
    CCDS678.1
    UniProtKB/Swiss-Prot
    Q8TEY7
    Related
    ENSP00000359829.1, ENST00000370793.5
    Conserved Domains (6) summary
    smart00695
    Location:840924
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:473713
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:186288
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:184712
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:61121
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:734803
    DUSP; DUSP domain
  12. NM_201624.3NP_963918.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 2

    See identical proteins and their annotated locations for NP_963918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF383173, AI569971, BC016663
    Consensus CDS
    CCDS679.1
    UniProtKB/Swiss-Prot
    Q8TEY7
    Related
    ENSP00000359830.3, ENST00000370794.7
    Conserved Domains (6) summary
    smart00695
    Location:809893
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:442682
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:155257
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:153681
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:703772
    DUSP; DUSP domain
  13. NM_201626.3NP_963920.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 3

    See identical proteins and their annotated locations for NP_963920.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region and differs in the 3' UTR compared to variant 1. The encoded isoform (3) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC114487, AF383172, BC016663
    Consensus CDS
    CCDS680.1
    UniProtKB/Swiss-Prot
    Q8TEY7
    Related
    ENSP00000359828.3, ENST00000370792.7
    Conserved Domains (3) summary
    pfam00443
    Location:185704
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:39285
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cl12116
    Location:726795
    DUSP; DUSP domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    77695987..77759852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000729.1XP_016856218.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X10

  2. XM_011541056.2XP_011539358.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X11

    Conserved Domains (3) summary
    cd02257
    Location:461595
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cl02553
    Location:184289
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:61121
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
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