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USP33 ubiquitin specific peptidase 33 [ Homo sapiens (human) ]

Gene ID: 23032, updated on 9-Dec-2018

Summary

Official Symbol
USP33provided by HGNC
Official Full Name
ubiquitin specific peptidase 33provided by HGNC
Primary source
HGNC:HGNC:20059
See related
Ensembl:ENSG00000077254 MIM:615146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VDU1
Summary
This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Expression
Ubiquitous expression in fat (RPKM 19.0), brain (RPKM 15.9) and 25 other tissues See more
Orthologs

Genomic context

See USP33 in Genome Data Viewer
Location:
1p31.1
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (77695987..77759879, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78161672..78225564, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger ZZ-type containing 3 Neighboring gene RNA, 5S ribosomal pseudogene 20 Neighboring gene RNA, 7SL, cytoplasmic 370, pseudogene Neighboring gene actin gamma 1 pseudogene 21 Neighboring gene RNA, 5S ribosomal pseudogene 21 Neighboring gene mitoguardin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1097, MGC16868

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Ral GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity TAS
Traceable Author Statement
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity TAS
Traceable Author Statement
more info
 
NOT ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
VCB complex TAS
Traceable Author Statement
more info
PubMed 
cell body IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 33
Names
VHL-interacting deubiquitinating enzyme 1
deubiquitinating enzyme 33
pVHL-interacting deubiquitinating enzyme 1
ubiquitin thioesterase 33
ubiquitin thiolesterase 33
ubiquitin-specific-processing protease 33
NP_055832.3
NP_963918.1
NP_963920.1
XP_005270705.1
XP_005270706.1
XP_011539357.1
XP_011539358.1
XP_016856211.1
XP_016856212.1
XP_016856213.1
XP_016856214.1
XP_016856215.1
XP_016856216.1
XP_016856217.1
XP_016856218.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015017.4NP_055832.3  ubiquitin carboxyl-terminal hydrolase 33 isoform 1

    See identical proteins and their annotated locations for NP_055832.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF383172, AF383173, AI569971, BC016663, DB232523
    Consensus CDS
    CCDS678.1
    UniProtKB/Swiss-Prot
    Q8TEY7
    Related
    ENSP00000359829.1, ENST00000370793.5
    Conserved Domains (6) summary
    smart00695
    Location:840924
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:473713
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:186288
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:184712
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:61121
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:734803
    DUSP; DUSP domain
  2. NM_201624.2NP_963918.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 2

    See identical proteins and their annotated locations for NP_963918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF383173, AI569971, BC016663, DB232523
    Consensus CDS
    CCDS679.1
    UniProtKB/Swiss-Prot
    Q8TEY7
    Related
    ENSP00000359830.3, ENST00000370794.7
    Conserved Domains (6) summary
    smart00695
    Location:809893
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:442682
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:155257
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:153681
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:703772
    DUSP; DUSP domain
  3. NM_201626.2NP_963920.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 3

    See identical proteins and their annotated locations for NP_963920.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region and differs in the 3' UTR compared to variant 1. The encoded isoform (3) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF383172, BC016663, DB232523
    Consensus CDS
    CCDS680.1
    UniProtKB/Swiss-Prot
    Q8TEY7
    Related
    ENSP00000359828.3, ENST00000370792.7
    Conserved Domains (3) summary
    pfam00443
    Location:185704
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl02553
    Location:39285
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cl12116
    Location:726795
    DUSP; DUSP domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    77695987..77759879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000726.2XP_016856215.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X8

  2. XM_017000724.2XP_016856213.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X6

  3. XM_017000725.2XP_016856214.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X7

  4. XM_017000722.2XP_016856211.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X2

  5. XM_005270648.1XP_005270705.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X1

    Conserved Domains (6) summary
    smart00695
    Location:832916
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:473705
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:185215
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:184704
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:61121
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:726795
    DUSP; DUSP domain
  6. XM_017000729.1XP_016856218.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X10

  7. XM_011541055.1XP_011539357.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X4

    Conserved Domains (4) summary
    smart00695
    Location:741825
    DUSP; Domain in ubiquitin-specific proteases
    cl02553
    Location:473671
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:184671
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:61121
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  8. XM_005270649.1XP_005270706.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X3

    Conserved Domains (6) summary
    cd02674
    Location:473713
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:186288
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:184712
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:61121
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    pfam14797
    Location:310410
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    cl12116
    Location:734803
    DUSP; DUSP domain
  9. XM_017000727.2XP_016856216.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X9

  10. XM_017000728.2XP_016856217.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X9

  11. XM_017000723.2XP_016856212.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X5

  12. XM_011541056.2XP_011539358.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X11

    Conserved Domains (3) summary
    cd02257
    Location:461595
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cl02553
    Location:184289
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:61121
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
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