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MAST3 microtubule associated serine/threonine kinase 3 [ Homo sapiens (human) ]

Gene ID: 23031, updated on 25-Nov-2021

Summary

Official Symbol
MAST3provided by HGNC
Official Full Name
microtubule associated serine/threonine kinase 3provided by HGNC
Primary source
HGNC:HGNC:19036
See related
Ensembl:ENSG00000099308 MIM:612258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 16.8), spleen (RPKM 6.6) and 24 other tissues See more
Orthologs
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Genomic context

See MAST3 in Genome Data Viewer
Location:
19p13.11
Exon count:
34
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18097778..18151692)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18208588..18262497)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S18 pseudogene 13 Neighboring gene Sharpr-MPRA regulatory region 12288 Neighboring gene interleukin 12 receptor subunit beta 1 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene IFI30 lysosomal thiol reductase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0561

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
microtubule-associated serine/threonine-protein kinase 3
NP_001380430.1
NP_001380431.1
NP_001380432.1
NP_001380433.1
NP_001380434.1
NP_001380435.1
NP_001380436.1
NP_001380437.1
NP_001380438.1
NP_001380439.1
NP_001380440.1
NP_001380441.1
NP_001380442.1
NP_001380443.1
NP_001380444.1
NP_001380445.1
NP_001380446.1
NP_001380447.1
NP_001380448.1
NP_001380449.1
NP_001380450.1
NP_055831.1
XP_006722761.1
XP_006722762.2
XP_016881995.1
XP_016881996.1
XP_016881997.1
XP_016881998.1
XP_016881999.1
XP_016882003.1
XP_016882004.1
XP_016882005.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393501.1NP_001380430.1  microtubule-associated serine/threonine-protein kinase 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC020904, AC093054
    Conserved Domains (3) summary
    smart00228
    Location:9881069
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:403682
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:88368
    DUF1908; Domain of unknown function (DUF1908)
  2. NM_001393502.1NP_001380431.1  microtubule-associated serine/threonine-protein kinase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC020904, AC093054
    Conserved Domains (2) summary
    smart00228
    Location:9811062
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:396675
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  3. NM_001393503.1NP_001380432.1  microtubule-associated serine/threonine-protein kinase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC093054
    Conserved Domains (3) summary
    smart00228
    Location:9801061
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:395674
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:80360
    DUF1908; Domain of unknown function (DUF1908)
  4. NM_001393504.1NP_001380433.1  microtubule-associated serine/threonine-protein kinase 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC020904, AC093054
    Conserved Domains (2) summary
    smart00228
    Location:9801061
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:395674
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  5. NM_001393505.1NP_001380434.1  microtubule-associated serine/threonine-protein kinase 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC093054
    Conserved Domains (2) summary
    smart00228
    Location:9791060
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:394673
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  6. NM_001393506.1NP_001380435.1  microtubule-associated serine/threonine-protein kinase 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC093054
    Conserved Domains (3) summary
    smart00228
    Location:9641045
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:379658
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64344
    DUF1908; Domain of unknown function (DUF1908)
  7. NM_001393507.1NP_001380436.1  microtubule-associated serine/threonine-protein kinase 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC093054
    Conserved Domains (2) summary
    smart00228
    Location:9731054
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:388667
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  8. NM_001393508.1NP_001380437.1  microtubule-associated serine/threonine-protein kinase 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC020904, AC093054
    Conserved Domains (3) summary
    smart00228
    Location:9581039
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:373652
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:58338
    DUF1908; Domain of unknown function (DUF1908)
  9. NM_001393509.1NP_001380438.1  microtubule-associated serine/threonine-protein kinase 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC020904, AC093054
    Conserved Domains (3) summary
    smart00228
    Location:9571038
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:372651
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:57337
    DUF1908; Domain of unknown function (DUF1908)
  10. NM_001393510.1NP_001380439.1  microtubule-associated serine/threonine-protein kinase 3 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC093054
    Conserved Domains (2) summary
    smart00228
    Location:9571038
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:372651
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  11. NM_001393511.1NP_001380440.1  microtubule-associated serine/threonine-protein kinase 3 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC093054
    Conserved Domains (3) summary
    smart00228
    Location:9561037
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:371650
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:63336
    DUF1908; Domain of unknown function (DUF1908)
  12. NM_001393512.1NP_001380441.1  microtubule-associated serine/threonine-protein kinase 3 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC020904, AC093054
    Conserved Domains (2) summary
    smart00228
    Location:9571038
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:372651
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  13. NM_001393513.1NP_001380442.1  microtubule-associated serine/threonine-protein kinase 3 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC093054
    Conserved Domains (2) summary
    smart00228
    Location:9641045
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:379658
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  14. NM_001393514.1NP_001380443.1  microtubule-associated serine/threonine-protein kinase 3 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC020904, AC093054
    Conserved Domains (3) summary
    smart00228
    Location:9511032
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:366645
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:58331
    DUF1908; Domain of unknown function (DUF1908)
  15. NM_001393515.1NP_001380444.1  microtubule-associated serine/threonine-protein kinase 3 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC020904, AC093054
    Conserved Domains (3) summary
    smart00228
    Location:9501031
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:365644
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:57330
    DUF1908; Domain of unknown function (DUF1908)
  16. NM_001393516.1NP_001380445.1  microtubule-associated serine/threonine-protein kinase 3 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC020904, AC093054
    Conserved Domains (2) summary
    smart00228
    Location:9581039
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:373652
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  17. NM_001393517.1NP_001380446.1  microtubule-associated serine/threonine-protein kinase 3 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC093054
    Conserved Domains (3) summary
    smart00228
    Location:9571038
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:372651
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64337
    DUF1908; Domain of unknown function (DUF1908)
  18. NM_001393518.1NP_001380447.1  microtubule-associated serine/threonine-protein kinase 3 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC020904, AC093054
    Conserved Domains (2) summary
    smart00228
    Location:9571038
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:372651
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  19. NM_001393519.1NP_001380448.1  microtubule-associated serine/threonine-protein kinase 3 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC093054
    Conserved Domains (3) summary
    smart00228
    Location:9561037
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:371650
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:63336
    DUF1908; Domain of unknown function (DUF1908)
  20. NM_001393520.1NP_001380449.1  microtubule-associated serine/threonine-protein kinase 3 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC020904, AC093054
    Conserved Domains (2) summary
    smart00228
    Location:9501031
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:365644
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  21. NM_001393521.1NP_001380450.1  microtubule-associated serine/threonine-protein kinase 3 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC005793, AC007192, AC093054
    Conserved Domains (2) summary
    smart00228
    Location:9421023
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:357636
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  22. NM_015016.2NP_055831.1  microtubule-associated serine/threonine-protein kinase 3 isoform 20

    See identical proteins and their annotated locations for NP_055831.1

    Status: VALIDATED

    Source sequence(s)
    AB011133, AC020904, BI907332, BQ340083, DA134568
    Consensus CDS
    CCDS46014.1
    UniProtKB/Swiss-Prot
    O60307
    Related
    ENSP00000262811.4, ENST00000262811.10
    Conserved Domains (4) summary
    smart00220
    Location:367640
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:9511032
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:366645
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:58331
    DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18097778..18151692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026514.1XP_016882003.1  microtubule-associated serine/threonine-protein kinase 3 isoform X15

    Conserved Domains (4) summary
    smart00220
    Location:292565
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:876957
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:291570
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:5256
    DUF1908; Domain of unknown function (DUF1908)
  2. XM_017026508.1XP_016881997.1  microtubule-associated serine/threonine-protein kinase 3 isoform X4

  3. XM_006722699.2XP_006722762.2  microtubule-associated serine/threonine-protein kinase 3 isoform X1

    Conserved Domains (4) summary
    smart00220
    Location:468741
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:10521133
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:467746
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:152432
    DUF1908; Domain of unknown function (DUF1908)
  4. XM_017026509.1XP_016881998.1  microtubule-associated serine/threonine-protein kinase 3 isoform X5

  5. XM_017026507.1XP_016881996.1  microtubule-associated serine/threonine-protein kinase 3 isoform X3

  6. XM_017026510.2XP_016881999.1  microtubule-associated serine/threonine-protein kinase 3 isoform X6

  7. XM_017026506.1XP_016881995.1  microtubule-associated serine/threonine-protein kinase 3 isoform X2

  8. XM_017026516.1XP_016882005.1  microtubule-associated serine/threonine-protein kinase 3 isoform X18

  9. XM_006722698.2XP_006722761.1  microtubule-associated serine/threonine-protein kinase 3 isoform X15

    Conserved Domains (4) summary
    smart00220
    Location:292565
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:876957
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:291570
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:5256
    DUF1908; Domain of unknown function (DUF1908)
  10. XM_017026515.1XP_016882004.1  microtubule-associated serine/threonine-protein kinase 3 isoform X15

    Conserved Domains (4) summary
    smart00220
    Location:292565
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:876957
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:291570
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:5256
    DUF1908; Domain of unknown function (DUF1908)
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