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MAST3 microtubule associated serine/threonine kinase 3 [ Homo sapiens (human) ]

Gene ID: 23031, updated on 12-Oct-2019

Summary

Official Symbol
MAST3provided by HGNC
Official Full Name
microtubule associated serine/threonine kinase 3provided by HGNC
Primary source
HGNC:HGNC:19036
See related
Ensembl:ENSG00000099308 MIM:612258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 16.8), spleen (RPKM 6.6) and 24 other tissues See more
Orthologs

Genomic context

See MAST3 in Genome Data Viewer
Location:
19p13.11
Exon count:
34
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18097764..18151692)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18208585..18262502)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S18 pseudogene 13 Neighboring gene Sharpr-MPRA regulatory region 12288 Neighboring gene interleukin 12 receptor subunit beta 1 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene IFI30 lysosomal thiol reductase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0561

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
microtubule-associated serine/threonine-protein kinase 3
NP_055831.1
XP_005259880.1
XP_005259881.1
XP_005259882.1
XP_005259883.1
XP_005259884.1
XP_006722761.1
XP_006722762.2
XP_006722763.1
XP_011526125.1
XP_016881995.1
XP_016881996.1
XP_016881997.1
XP_016881998.1
XP_016881999.1
XP_016882000.1
XP_016882001.1
XP_016882002.1
XP_016882003.1
XP_016882004.1
XP_016882005.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015016.2NP_055831.1  microtubule-associated serine/threonine-protein kinase 3

    See identical proteins and their annotated locations for NP_055831.1

    Status: VALIDATED

    Source sequence(s)
    AB011133, AC020904, BI907332, BQ340083, DA134568
    Consensus CDS
    CCDS46014.1
    UniProtKB/Swiss-Prot
    O60307
    Related
    ENSP00000262811.4, ENST00000262811.10
    Conserved Domains (4) summary
    smart00220
    Location:367640
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:9511032
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:366645
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:58331
    DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18097764..18151692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527823.1XP_011526125.1  microtubule-associated serine/threonine-protein kinase 3 isoform X7

    Conserved Domains (4) summary
    smart00220
    Location:404677
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:9881069
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:403682
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:88368
    DUF1908; Domain of unknown function (DUF1908)
  2. XM_005259824.2XP_005259881.1  microtubule-associated serine/threonine-protein kinase 3 isoform X9

    Conserved Domains (4) summary
    smart00220
    Location:374647
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:9581039
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:373652
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:58338
    DUF1908; Domain of unknown function (DUF1908)
  3. XM_017026512.1XP_016882001.1  microtubule-associated serine/threonine-protein kinase 3 isoform X12

  4. XM_005259825.2XP_005259882.1  microtubule-associated serine/threonine-protein kinase 3 isoform X10

    Conserved Domains (4) summary
    smart00220
    Location:373646
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:9571038
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:372651
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:57337
    DUF1908; Domain of unknown function (DUF1908)
  5. XM_017026513.1XP_016882002.1  microtubule-associated serine/threonine-protein kinase 3 isoform X13

  6. XM_017026514.1XP_016882003.1  microtubule-associated serine/threonine-protein kinase 3 isoform X15

    Conserved Domains (4) summary
    smart00220
    Location:292565
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:876957
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:291570
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:5256
    DUF1908; Domain of unknown function (DUF1908)
  7. XM_017026508.1XP_016881997.1  microtubule-associated serine/threonine-protein kinase 3 isoform X4

  8. XM_006722699.2XP_006722762.2  microtubule-associated serine/threonine-protein kinase 3 isoform X1

    Conserved Domains (4) summary
    smart00220
    Location:468741
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:10521133
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:467746
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:152432
    DUF1908; Domain of unknown function (DUF1908)
  9. XM_017026509.1XP_016881998.1  microtubule-associated serine/threonine-protein kinase 3 isoform X5

  10. XM_017026507.1XP_016881996.1  microtubule-associated serine/threonine-protein kinase 3 isoform X3

  11. XM_017026510.2XP_016881999.1  microtubule-associated serine/threonine-protein kinase 3 isoform X6

  12. XM_017026506.1XP_016881995.1  microtubule-associated serine/threonine-protein kinase 3 isoform X2

  13. XM_017026516.1XP_016882005.1  microtubule-associated serine/threonine-protein kinase 3 isoform X18

  14. XM_017026511.1XP_016882000.1  microtubule-associated serine/threonine-protein kinase 3 isoform X8

  15. XM_006722698.2XP_006722761.1  microtubule-associated serine/threonine-protein kinase 3 isoform X15

    Conserved Domains (4) summary
    smart00220
    Location:292565
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:876957
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:291570
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:5256
    DUF1908; Domain of unknown function (DUF1908)
  16. XM_017026515.1XP_016882004.1  microtubule-associated serine/threonine-protein kinase 3 isoform X15

    Conserved Domains (4) summary
    smart00220
    Location:292565
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:876957
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:291570
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:5256
    DUF1908; Domain of unknown function (DUF1908)
  17. XM_005259823.3XP_005259880.1  microtubule-associated serine/threonine-protein kinase 3 isoform X16

    Conserved Domains (4) summary
    smart00220
    Location:380653
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:9641045
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:379658
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64344
    DUF1908; Domain of unknown function (DUF1908)
  18. XM_005259826.3XP_005259883.1  microtubule-associated serine/threonine-protein kinase 3 isoform X11

    Conserved Domains (4) summary
    smart00220
    Location:372645
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:9561037
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:371650
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:63336
    DUF1908; Domain of unknown function (DUF1908)
  19. XM_006722700.3XP_006722763.1  microtubule-associated serine/threonine-protein kinase 3 isoform X17

    Conserved Domains (4) summary
    smart00220
    Location:372645
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:9561037
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:371650
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:63336
    DUF1908; Domain of unknown function (DUF1908)
  20. XM_005259827.3XP_005259884.1  microtubule-associated serine/threonine-protein kinase 3 isoform X14

    Conserved Domains (4) summary
    smart00220
    Location:373646
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00228
    Location:9571038
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd05609
    Location:372651
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64337
    DUF1908; Domain of unknown function (DUF1908)
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