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MYO16 myosin XVI [ Homo sapiens (human) ]

Gene ID: 23026, updated on 4-Jun-2020

Summary

Official Symbol
MYO16provided by HGNC
Official Full Name
myosin XVIprovided by HGNC
Primary source
HGNC:HGNC:29822
See related
Ensembl:ENSG00000041515 MIM:615479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYR8; MYAP3; NYAP3; Myo16b; PPP1R107
Summary
This gene encodes an unconventional myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017]
Expression
Biased expression in brain (RPKM 1.6), fat (RPKM 1.1) and 8 other tissues See more
Orthologs

Genomic context

See MYO16 in Genome Data Viewer
Location:
13q33.3
Exon count:
37
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (108495729..109208005)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (109248500..109860355)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370355 Neighboring gene host cell factor C2 pseudogene 1 Neighboring gene uncharacterized LOC105370356 Neighboring gene MYO16 antisense RNA 1 Neighboring gene uncharacterized LOC105370359 Neighboring gene heart enhancer 14 Neighboring gene long intergenic non-protein coding RNA 399

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene network analysis in a pediatric cohort identifies novel lung function genes.
NHGRI GWA Catalog
Genome-wide association study of antiphospholipid antibodies.
NHGRI GWA Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
NHGRI GWA Catalog
Genome-wide linkage and association scans for pulse pressure in Chinese twins.
NHGRI GWA Catalog
GWAS of dental caries patterns in the permanent dentition.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0865

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
motor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cerebellum development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
myosin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-XVI
Names
MYO16 variant protein
myosin heavy chain Myr 8
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3
protein phosphatase 1, regulatory subunit 107
unconventional myosin-16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053147.1 RefSeqGene

    Range
    105424..717279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198950.3NP_001185879.1  unconventional myosin-XVI isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL136132, AL157771, AL161431, AL353143, AL390918
    Consensus CDS
    CCDS73598.1
    UniProtKB/TrEMBL
    F8W883
    Related
    ENSP00000401633.3, ENST00000457511.7
    Conserved Domains (6) summary
    smart00242
    Location:4261165
    MYSc; Myosin. Large ATPases
    COG0666
    Location:81332
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:142297
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14878
    Location:4371155
    MYSc_Myo16; class XVI myosin, motor domain
    pfam15439
    Location:12531590
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    sd00045
    Location:243274
    ANK; ANK repeat [structural motif]
  2. NM_015011.3NP_055826.1  unconventional myosin-XVI isoform 2

    See identical proteins and their annotated locations for NP_055826.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL136132, AL157771, AL161431, AL353143, AL390918, AL512648
    Consensus CDS
    CCDS32008.1
    UniProtKB/Swiss-Prot
    Q9Y6X6
    Related
    ENSP00000349145.2, ENST00000356711.7
    Conserved Domains (6) summary
    smart00242
    Location:4041143
    MYSc; Myosin. Large ATPases
    COG0666
    Location:59310
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:120275
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14878
    Location:4151133
    MYSc_Myo16; class XVI myosin, motor domain
    pfam15439
    Location:12311568
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    sd00045
    Location:221252
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    108495729..109208005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521062.1XP_011519364.1  unconventional myosin-XVI isoform X1

    See identical proteins and their annotated locations for XP_011519364.1

    UniProtKB/Swiss-Prot
    Q9Y6X6
    Conserved Domains (6) summary
    smart00242
    Location:4041143
    MYSc; Myosin. Large ATPases
    COG0666
    Location:59310
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:120275
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14878
    Location:4151133
    MYSc_Myo16; class XVI myosin, motor domain
    pfam15439
    Location:12311568
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    sd00045
    Location:221252
    ANK; ANK repeat [structural motif]

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_013171811.1 Reference GRCh38.p13 PATCHES

    Range
    25478..116873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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