U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ecpas Ecm29 proteasome adaptor and scaffold [ Mus musculus (house mouse) ]

Gene ID: 230249, updated on 9-May-2024

Summary

Official Symbol
Ecpasprovided by MGI
Official Full Name
Ecm29 proteasome adaptor and scaffoldprovided by MGI
Primary source
MGI:MGI:2140220
See related
Ensembl:ENSMUSG00000050812 AllianceGenome:MGI:2140220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0368
Summary
Predicted to enable proteasome binding activity. Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be located in several cellular components, including centrosome; cytoplasmic vesicle; and nucleoplasm. Predicted to be part of proteasome complex. Orthologous to human ECPAS (Ecm29 proteasome adaptor and scaffold). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.2), bladder adult (RPKM 5.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ecpas in Genome Data Viewer
Location:
4 B3; 4 32.35 cM
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (58797234..58917748, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (58797234..58917748, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12579 Neighboring gene STARR-seq mESC enhancer starr_10362 Neighboring gene STARR-seq mESC enhancer starr_10364 Neighboring gene STARR-seq mESC enhancer starr_10365 Neighboring gene olfactory receptor family 2 subfamily K member 2 Neighboring gene STARR-positive B cell enhancer ABC_E6181 Neighboring gene zinc finger with KRAB and SCAN domains 16 Neighboring gene prostaglandin reductase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0368

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proteasome adapter and scaffold protein ECM29
Names
ecm29
proteasome-associated protein ECM29 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355696.1NP_001342625.1  proteasome adapter and scaffold protein ECM29 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK030369, AK043020, AK054077, AL806535, AW123771, BC058684, BE648557, BG079097
    UniProtKB/TrEMBL
    A2ALV7
    Conserved Domains (2) summary
    sd00044
    Location:10851108
    HEAT; HEAT repeat [structural motif]
    pfam13001
    Location:16523
    Ecm29; Proteasome stabilizer
  2. NM_001355697.1NP_001342626.1  proteasome adapter and scaffold protein ECM29 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK030369, AK043020, AK054077, AL806535, AW123771, BC058684, BE648557, BG079097
    UniProtKB/Swiss-Prot
    A2ALW0, Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6
    UniProtKB/TrEMBL
    A2ALV7
    Related
    ENSMUSP00000117585.2, ENSMUST00000149301.8
    Conserved Domains (2) summary
    sd00044
    Location:10791102
    HEAT; HEAT repeat [structural motif]
    pfam13001
    Location:10517
    Ecm29; Proteasome stabilizer
  3. NM_172381.3NP_759013.2  proteasome adapter and scaffold protein ECM29 isoform 2

    See identical proteins and their annotated locations for NP_759013.2

    Status: VALIDATED

    Source sequence(s)
    AK030369, AK041579, AK054077, AL806535, AW123771, BC058684, BE648557, BG079097
    Consensus CDS
    CCDS18214.1
    UniProtKB/TrEMBL
    A2ALV7
    Related
    ENSMUSP00000099953.4, ENSMUST00000102889.10
    Conserved Domains (2) summary
    pfam13001
    Location:10517
    Ecm29; Proteasome stabilizer
    sd00044
    Location:10791102
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    58797234..58917748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537848.4XP_006537911.1  proteasome adapter and scaffold protein ECM29 isoform X1

    See identical proteins and their annotated locations for XP_006537911.1

    UniProtKB/Swiss-Prot
    A2ALW0, Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6
    UniProtKB/TrEMBL
    A2ALV7
    Conserved Domains (2) summary
    sd00044
    Location:10791102
    HEAT; HEAT repeat [structural motif]
    pfam13001
    Location:10517
    Ecm29; Proteasome stabilizer
  2. XM_006537850.5XP_006537913.1  proteasome adapter and scaffold protein ECM29 isoform X2

    UniProtKB/TrEMBL
    A2ALV7
    Conserved Domains (2) summary
    sd00044
    Location:10271050
    HEAT; HEAT repeat [structural motif]
    pfam13001
    Location:1465
    Ecm29; Proteasome stabilizer