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Elp1 elongator complex protein 1 [ Mus musculus (house mouse) ]

Gene ID: 230233, updated on 6-Nov-2018

Summary

Official Symbol
Elp1provided by MGI
Official Full Name
elongator complex protein 1provided by MGI
Primary source
MGI:MGI:1914544
See related
Ensembl:ENSMUSG00000028431 Vega:OTTMUSG00000007272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IKAP; C78473; Ikbkap; 6030413P05; 3110040G09Rik
Expression
Broad expression in CNS E18 (RPKM 13.8), CNS E11.5 (RPKM 13.3) and 25 other tissues See more
Orthologs

Genomic context

See Elp1 in Genome Data Viewer
Location:
4 B3; 4 31.66 cM
Exon count:
37
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (56749680..56802331, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (56762552..56815203, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene actin-like 7b Neighboring gene actin-like 7a Neighboring gene family with sequence similarity 206, member A Neighboring gene catenin (cadherin associated protein), alpha-like 1 Neighboring gene transmembrane protein 245 Neighboring gene microRNA 32

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
 
phosphorylase kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Elongator holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
elongator complex protein 1
Names
IKK complex-associated protein
IKK-complex-associated protein IKAP
ikappaB kinase complex-associated protein
inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026079.3NP_080355.2  elongator complex protein 1

    Status: VALIDATED

    Source sequence(s)
    AK032563, AK035944, AK076152, AK147153, AK165168
    Consensus CDS
    CCDS38765.1
    UniProtKB/Swiss-Prot
    Q7TT37
    Related
    ENSMUSP00000030140.2, OTTMUSP00000007743, ENSMUST00000030140.2, OTTMUST00000016798
    Conserved Domains (4) summary
    COG0457
    Location:8751101
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG5290
    Location:711276
    COG5290; IkappaB kinase complex, IKAP component [Transcription]
    pfam04762
    Location:1955
    IKI3; IKI3 family
    sd00039
    Location:112147
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    56749680..56802331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_390319.1 RNA Sequence

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