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EXOSC7 exosome component 7 [ Homo sapiens (human) ]

Gene ID: 23016, updated on 1-Jun-2020

Summary

Official Symbol
EXOSC7provided by HGNC
Official Full Name
exosome component 7provided by HGNC
Primary source
HGNC:HGNC:28112
See related
Ensembl:ENSG00000075914 MIM:606488
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p8; EAP1; RRP42; Rrp42p; hRrp42p
Expression
Ubiquitous expression in adrenal (RPKM 11.2), skin (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See EXOSC7 in Genome Data Viewer
Location:
3p21.31
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (44975291..45012668)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45017741..45054160)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3821 Neighboring gene transglutaminase 4 Neighboring gene zinc finger DHHC-type palmitoyltransferase 3 Neighboring gene ribosomal protein L12 pseudogene 44 Neighboring gene C-type lectin domain family 3 member B Neighboring gene RNA, U5B small nuclear 3, pseudogene Neighboring gene CUB domain containing protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, exosome component 7 (EXOSC7), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26543, KIAA0116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity TAS
Traceable Author Statement
more info
PubMed 
AU-rich element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
NOT exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
U1 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U5 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
Traceable Author Statement
more info
 
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear polyadenylation-dependent mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear polyadenylation-dependent tRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
PubMed 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
exosome (RNase complex) TAS
Traceable Author Statement
more info
PubMed 
nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
exosome complex component RRP42
Names
exosome complex exonuclease RRP42
ribosomal RNA-processing protein 42
NP_055819.2
XP_016861419.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015004.4NP_055819.2  exosome complex component RRP42

    See identical proteins and their annotated locations for NP_055819.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AC104165, AK315741, BC012831
    Consensus CDS
    CCDS2725.1
    UniProtKB/Swiss-Prot
    Q15024
    UniProtKB/TrEMBL
    A0A024R2P7, B2RDZ9
    Related
    ENSP00000265564.7, ENST00000265564.8
    Conserved Domains (2) summary
    cd11367
    Location:6276
    RNase_PH_RRP42; RRP42 subunit of eukaryotic exosome
    COG2123
    Location:1273
    Rrp42; Exosome complex RNA-binding protein Rrp42, RNase PH superfamily [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_023353.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) omits two coding exons resulting in a frameshift and prematurely truncated open reading frame. The transcript is a candidate for nonsense-mediated decay.
    Source sequence(s)
    AC104165, AK130053, AK315741, BC012831, BU153856

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    44975291..45012668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005930.2XP_016861419.1  exosome complex component RRP42 isoform X1

RNA

  1. XR_001740061.1 RNA Sequence

    Related
    ENST00000461361.5
  2. XR_001740062.1 RNA Sequence

  3. XR_245104.4 RNA Sequence

    Related
    ENST00000491476.5
  4. XR_940394.3 RNA Sequence

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