Galnt12 polypeptide N-acetylgalactosaminyltransferase 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Galnt12provided by MGI
Official Full Name: polypeptide N-acetylgalactosaminyltransferase 12provided by MGI
Primary source: MGI:MGI:2444664
See related: Ensembl:ENSMUSG00000039774 AllianceGenome:MGI:2444664
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9130206E10; galNAc-T12; pp-GaNTase; A630062B03Rik; mpp-GalNAc-T12
Summary: Predicted to enable carbohydrate binding activity; metal ion binding activity; and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; hemolymphoid system; nervous system; and tail. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human GALNT12 (polypeptide N-acetylgalactosaminyltransferase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 53.1), stomach adult (RPKM 17.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 B1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (47091894..47123058)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (47091894..47123058)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

General gene information

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Homology

Homologs of the Galnt12 gene: The Galnt12 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 340 organisms have orthologs with human gene Galnt12
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables polypeptide N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: polypeptide N-acetylgalactosaminyltransferase 12

Names: UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12; polypeptide GalNAc transferase 12; pp-GaNTase 12; protein-UDP acetylgalactosaminyltransferase 12

NP_766281.1

EC 2.4.1.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172693.4 → NP_766281.1 polypeptide N-acetylgalactosaminyltransferase 12

See identical proteins and their annotated locations for NP_766281.1

Status: VALIDATED

Source sequence(s)

AK033638, AK043977, CK627557

Consensus CDS

CCDS18158.1

UniProtKB/Swiss-Prot

Q8BGT9

UniProtKB/TrEMBL

Q60GT3

Related

ENSMUSP00000045721.6, ENSMUST00000045041.12

Conserved Domains (4) summary

cd02510
Location:134 → 428

pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans

COG0463
Location:129 → 424

WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]

cd00161
Location:442 → 571

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

pfam00652
Location:440 → 569

Ricin_B_lectin; Ricin-type beta-trefoil lectin domain