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FBXO21 F-box protein 21 [ Homo sapiens (human) ]

Gene ID: 23014, updated on 12-Oct-2019

Summary

Official Symbol
FBXO21provided by HGNC
Official Full Name
F-box protein 21provided by HGNC
Primary source
HGNC:HGNC:13592
See related
Ensembl:ENSG00000135108 MIM:609095
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX21
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 31.4), ovary (RPKM 26.9) and 25 other tissues See more
Orthologs

Genomic context

See FBXO21 in Genome Data Viewer
Location:
12q24.22
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (117141991..117190471, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (117581278..117628305, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tescalcin Neighboring gene uncharacterized LOC105370010 Neighboring gene TESC antisense RNA 1 (head to head) Neighboring gene nitric oxide synthase 1 Neighboring gene elongin C pseudogene 32 Neighboring gene NOS1 1f and 1g alternate promoter region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of F-box protein 21 (FBXO21) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90233, KIAA0875, MGC26682, DKFZp434G058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015002.3NP_055817.1  F-box only protein 21 isoform 2

    See identical proteins and their annotated locations for NP_055817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a 21 nt fragment within the coding region, and thus encodes a 7 aa shorter isoform than variant 1.
    Source sequence(s)
    AB020682, AC026368, BC034045, BC042333, BI550121
    Consensus CDS
    CCDS44989.1
    UniProtKB/Swiss-Prot
    O94952
    UniProtKB/TrEMBL
    A0A024RBL8, Q4G104, Q8IUQ5
    Related
    ENSP00000483508.1, ENST00000622495.4
    Conserved Domains (3) summary
    TIGR02097
    Location:493590
    yccV; hemimethylated DNA binding domain
    pfam12937
    Location:3077
    F-box-like; F-box-like
    pfam13369
    Location:216388
    Transglut_core2; Transglutaminase-like superfamily
  2. NM_033624.3NP_296373.1  F-box only protein 21 isoform 1

    See identical proteins and their annotated locations for NP_296373.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an additional 21 nt fragment within the coding region, and thus encodes a 7 aa longer isoform than variant 2.
    Source sequence(s)
    AB020682, AC026368, AL136899, BC034045, BC042333, BI550121
    Consensus CDS
    CCDS9184.1
    UniProtKB/Swiss-Prot
    O94952
    UniProtKB/TrEMBL
    A0A024RBR2, Q4G104, Q8IUQ5
    Related
    ENSP00000328187.5, ENST00000330622.9
    Conserved Domains (3) summary
    TIGR02097
    Location:500597
    yccV; hemimethylated DNA binding domain
    pfam12937
    Location:3077
    F-box-like; F-box-like
    pfam13369
    Location:216388
    Transglut_core2; Transglutaminase-like superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    117141991..117190471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019037.2XP_016874526.1  F-box only protein 21 isoform X1

  2. XM_017019039.2XP_016874528.1  F-box only protein 21 isoform X3

  3. XM_017019038.2XP_016874527.1  F-box only protein 21 isoform X2

    Related
    ENSP00000449264.1, ENST00000550180.5
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