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SPEN spen family transcriptional repressor [ Homo sapiens (human) ]

Gene ID: 23013, updated on 9-Dec-2018

Summary

Official Symbol
SPENprovided by HGNC
Official Full Name
spen family transcriptional repressorprovided by HGNC
Primary source
HGNC:HGNC:17575
See related
Ensembl:ENSG00000065526 MIM:613484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MINT; SHARP; RBM15C; HIAA0929
Summary
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 13.5), bone marrow (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See SPEN in Genome Data Viewer
Location:
1p36.21-p36.13
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (15847864..15940455)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16174359..16266951)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase hinge protein like Neighboring gene ribosomal protein S16 pseudogene 1 Neighboring gene uncharacterized LOC729614 Neighboring gene NFE2L2 motif-containing MPRA enhancer 216 Neighboring gene zinc finger and BTB domain containing 17 Neighboring gene steroid receptor associated and regulated protein Neighboring gene heat shock protein family B (small) member 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of spen homolog, transcriptional regulator (Drosophila, SPEN) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CLCNKA

Homology

Clone Names

  • KIAA0929

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
msx2-interacting protein
Names
Msx2 interacting nuclear target (MINT) homolog
SMART/HDAC1-associated repressor protein
nuclear receptor transcription cofactor
spen homolog, transcriptional regulator

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050663.1 RefSeqGene

    Range
    5001..97592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015001.3NP_055816.2  msx2-interacting protein

    See identical proteins and their annotated locations for NP_055816.2

    Status: REVIEWED

    Source sequence(s)
    AF356524, AL034555, AL450998
    Consensus CDS
    CCDS164.1
    UniProtKB/Swiss-Prot
    Q96T58
    Related
    ENSP00000364912.3, ENST00000375759.7
    Conserved Domains (8) summary
    COG0724
    Location:881
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12348
    Location:781
    RRM1_SHARP; RNA recognition motif 1 in SMART/HDAC1-associated repressor protein (SHARP) and similar proteins
    cd12349
    Location:336409
    RRM2_SHARP; RNA recognition motif 2 in SMART/HDAC1-associated repressor protein (SHARP) and similar proteins
    cd12350
    Location:436509
    RRM3_SHARP; RNA recognition motif 3 in SMART/HDAC1-associated repressor protein (SHARP) and similar proteins
    cd12351
    Location:510586
    RRM4_SHARP; RNA recognition motif 4 in SMART/HDAC1-associated repressor protein (SHARP) and similar proteins
    pfam05466
    Location:15951804
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    pfam07744
    Location:35093630
    SPOC; SPOC domain
    pfam15984
    Location:26452723
    Collagen_mid; Bacterial collagen, middle region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    15847864..15940455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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