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STK38L serine/threonine kinase 38 like [ Homo sapiens (human) ]

Gene ID: 23012, updated on 5-Sep-2021

Summary

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Official Symbol
STK38Lprovided by HGNC
Official Full Name
serine/threonine kinase 38 likeprovided by HGNC
Primary source
HGNC:HGNC:17848
See related
Ensembl:ENSG00000211455 MIM:615836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDR2
Expression
Ubiquitous expression in gall bladder (RPKM 16.1), heart (RPKM 15.2) and 25 other tissues See more
Orthologs
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Genomic context

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See STK38L in Genome Data Viewer
Location:
12p11.23
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (27244233..27325959)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27397219..27478892)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene nontranscribed chromatin-defined enhancer upstream of C12orf71 Neighboring gene chromosome 12 open reading frame 71 Neighboring gene aryl hydrocarbon receptor nuclear translocator like 2 Neighboring gene ARNTL2 antisense RNA 1 Neighboring gene single-pass membrane protein with coiled-coil domains 2 Neighboring gene arginyl-tRNA synthetase 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Grant TJ, et al. Oncotarget, 2017 Oct 3. PMID 29108249, Free PMC Article
  2. NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages. Liu Z, et al. Sci Adv, 2019 Feb. PMID 30775439, Free PMC Article
  3. Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility. Chen H, et al. Int J Cancer, 2019 Nov 1. PMID 30714141
  4. [Role of PLAT, PKHD1L1, STK38L and TEAD1 genes Alu-polymorphism for longevity]. Erdman VV, et al. Adv Gerontol, 2016. PMID 28556638
  5. NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. Suzuki A, et al. J Biol Chem, 2006 May 19. PMID 16488889

See all (62) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results demonstrate that NDR2 is a reversible acetylated kinase regulated by SIRT1 and p300/CBP.
    Title: SIRT1 and p300/CBP regulate the reversible acetylation of serine-threonine kinase NDR2.
  2. NDR2 positively regulated an antiviral innate immune response in a kinase activity-independent manner. NDR2 interacts with RIG-I and promotes TRIM25-mediated RIG-I ubiquitination, which is required for downstream signaling activation and type I IFN production.
    Title: NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages.
  3. Study identified rs10842893 as a novel independent SNP in the gene STK38L that was significantly associated with glioma risk in Chinese population, and furthermore confirmed previously reported associations of rs498872 and rs6010620 with glioma risk in European descent population and Chinese Han population.
    Title: Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.
  4. This study shows that STK38L is co-amplified with oncogenic KRAS in pancreatic cancer cell lines, where it regulates LATS2 gene expression.
    Title: STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines.
  5. These results suggest that NDR2 may play important roles in IL-17-associated inflammation by promoting Smurf1-mediated MEKK2 ubiquitination and degradation.
    Title: Hippo kinase NDR2 inhibits IL-17 signaling by promoting Smurf1-mediated MEKK2 ubiquitination and degradation.
  6. It was found that STK38L*I/D genotype had positive association with longevity in the ethnically homogeneous group of Tatars from the Republic of Bashkortostan, Russia.
    Title: [Role of PLAT, PKHD1L1, STK38L and TEAD1 genes Alu-polymorphism for longevity].
  7. cyclin D1 has a role in promoting cell cycle progression by enhancing NDR1/2 kinase activity independent of Cdk4
    Title: Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4.
  8. NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by triggering the switch in binding specificity of Rabin8 from PS to Sec15.
    Title: NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15.
  9. These findings establish a novel MST3-NDR-p21 axis as an important regulator of G(1)/S progression of mammalian cells.
    Title: Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Two related serine-threonine kinases, nuclear Dbf2 related 1 (NDR1) and NDR2, are incorporated into HIV-1 particles and are cleaved by the HIV-1 protease (PR), both within virions and within producer cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0965

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cellular component organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 38-like
Names
NDR2 protein kinase
nuclear Dbf2-related 2
nuclear Dbf2-related kinase 2
NP_055815.1
XP_005253399.1
XP_006719121.1
XP_006719122.1
XP_011518915.1
XP_024304657.1
XP_024304658.1
XP_024304659.1
XP_024304660.1
XP_024304661.1
XP_024304662.1
XP_024304663.1
XP_024304664.1
XP_024304665.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015000.4 → NP_055815.1  serine/threonine-protein kinase 38-like

    See identical proteins and their annotated locations for NP_055815.1

    Status: VALIDATED

    Source sequence(s)
    AB023182, BU681056, BX390969
    Consensus CDS
    CCDS31761.1
    UniProtKB/Swiss-Prot
    Q9Y2H1
    Related
    ENSP00000373684.3, ENST00000389032.8
    Conserved Domains (1) summary
    cd05627
    Location:87 → 452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    27244233..27325959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719059.3 → XP_006719122.1  serine/threonine-protein kinase 38-like isoform X4

    See identical proteins and their annotated locations for XP_006719122.1

    Conserved Domains (1) summary
    cd05627
    Location:35 → 400
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  2. XM_024448889.1 → XP_024304657.1  serine/threonine-protein kinase 38-like isoform X1

    Conserved Domains (1) summary
    cd05627
    Location:87 → 509
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  3. XM_005253342.4 → XP_005253399.1  serine/threonine-protein kinase 38-like isoform X3

    See identical proteins and their annotated locations for XP_005253399.1

    Conserved Domains (2) summary
    smart00220
    Location:62 → 342
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:62 → 411
    PKc_like; Protein Kinases, catalytic domain

  4. XM_024448891.1 → XP_024304659.1  serine/threonine-protein kinase 38-like isoform X1

    Conserved Domains (1) summary
    cd05627
    Location:87 → 509
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  5. XM_006719058.4 → XP_006719121.1  serine/threonine-protein kinase 38-like isoform X2

    See identical proteins and their annotated locations for XP_006719121.1

    UniProtKB/Swiss-Prot
    Q9Y2H1
    Conserved Domains (1) summary
    cd05627
    Location:87 → 452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  6. XM_024448892.1 → XP_024304660.1  serine/threonine-protein kinase 38-like isoform X1

    Conserved Domains (1) summary
    cd05627
    Location:87 → 509
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  7. XM_024448897.1 → XP_024304665.1  serine/threonine-protein kinase 38-like isoform X2

    Conserved Domains (1) summary
    cd05627
    Location:87 → 452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  8. XM_024448893.1 → XP_024304661.1  serine/threonine-protein kinase 38-like isoform X1

    Conserved Domains (1) summary
    cd05627
    Location:87 → 509
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  9. XM_024448896.1 → XP_024304664.1  serine/threonine-protein kinase 38-like isoform X2

    Conserved Domains (1) summary
    cd05627
    Location:87 → 452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  10. XM_024448890.1 → XP_024304658.1  serine/threonine-protein kinase 38-like isoform X1

    Conserved Domains (1) summary
    cd05627
    Location:87 → 509
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  11. XM_024448894.1 → XP_024304662.1  serine/threonine-protein kinase 38-like isoform X2

    Conserved Domains (1) summary
    cd05627
    Location:87 → 452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  12. XM_024448895.1 → XP_024304663.1  serine/threonine-protein kinase 38-like isoform X2

    Conserved Domains (1) summary
    cd05627
    Location:87 → 452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  13. XM_011520613.2 → XP_011518915.1  serine/threonine-protein kinase 38-like isoform X5

    See identical proteins and their annotated locations for XP_011518915.1

    UniProtKB/Swiss-Prot
    Q9Y2H1
    Conserved Domains (2) summary
    smart00220
    Location:10 → 290
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:10 → 359
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001748626.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2H1.3 GenPept UniProtKB/Swiss-Prot:Q9Y2H1

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