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STK38L serine/threonine kinase 38 like [ Homo sapiens (human) ]

Gene ID: 23012, updated on 4-Nov-2018

Summary

Official Symbol
STK38Lprovided by HGNC
Official Full Name
serine/threonine kinase 38 likeprovided by HGNC
Primary source
HGNC:HGNC:17848
See related
Ensembl:ENSG00000211455 MIM:615836; Vega:OTTHUMG00000169284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDR2
Expression
Ubiquitous expression in gall bladder (RPKM 16.1), heart (RPKM 15.2) and 25 other tissues See more
Orthologs

Genomic context

See STK38L in Genome Data Viewer
Location:
12p11.23
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (27244145..27325959)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27397078..27478892)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene nontranscribed chromatin-defined enhancer upstream of C12orf71 Neighboring gene chromosome 12 open reading frame 71 Neighboring gene aryl hydrocarbon receptor nuclear translocator like 2 Neighboring gene ARNTL2 antisense RNA 1 Neighboring gene single-pass membrane protein with coiled-coil domains 2 Neighboring gene arginyl-tRNA synthetase pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Two related serine-threonine kinases, nuclear Dbf2 related 1 (NDR1) and NDR2, are incorporated into HIV-1 particles and are cleaved by the HIV-1 protease (PR), both within virions and within producer cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0965

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular component organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 38-like
Names
NDR2 protein kinase
nuclear Dbf2-related 2
nuclear Dbf2-related kinase 2
NP_055815.1
XP_005253399.1
XP_006719121.1
XP_006719122.1
XP_011518915.1
XP_024304657.1
XP_024304658.1
XP_024304659.1
XP_024304660.1
XP_024304661.1
XP_024304662.1
XP_024304663.1
XP_024304664.1
XP_024304665.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015000.3NP_055815.1  serine/threonine-protein kinase 38-like

    See identical proteins and their annotated locations for NP_055815.1

    Status: VALIDATED

    Source sequence(s)
    AB023182, BU681056, BX390969
    Consensus CDS
    CCDS31761.1
    UniProtKB/Swiss-Prot
    Q9Y2H1
    Related
    ENSP00000373684.3, OTTHUMP00000240676, ENST00000389032.7, OTTHUMT00000403297
    Conserved Domains (1) summary
    cd05627
    Location:87452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    27244145..27325959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719059.3XP_006719122.1  serine/threonine-protein kinase 38-like isoform X4

    See identical proteins and their annotated locations for XP_006719122.1

    Conserved Domains (2) summary
    smart00220
    Location:38331
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05627
    Location:35400
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
  2. XM_024448889.1XP_024304657.1  serine/threonine-protein kinase 38-like isoform X1

    Conserved Domains (1) summary
    cd05627
    Location:87509
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
  3. XM_005253342.4XP_005253399.1  serine/threonine-protein kinase 38-like isoform X3

    See identical proteins and their annotated locations for XP_005253399.1

    Conserved Domains (2) summary
    smart00220
    Location:62342
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:62411
    PKc_like; Protein Kinases, catalytic domain
  4. XM_024448891.1XP_024304659.1  serine/threonine-protein kinase 38-like isoform X1

    Conserved Domains (1) summary
    cd05627
    Location:87509
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
  5. XM_006719058.4XP_006719121.1  serine/threonine-protein kinase 38-like isoform X2

    See identical proteins and their annotated locations for XP_006719121.1

    UniProtKB/Swiss-Prot
    Q9Y2H1
    Conserved Domains (1) summary
    cd05627
    Location:87452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
  6. XM_024448892.1XP_024304660.1  serine/threonine-protein kinase 38-like isoform X1

    Conserved Domains (1) summary
    cd05627
    Location:87509
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
  7. XM_024448897.1XP_024304665.1  serine/threonine-protein kinase 38-like isoform X2

  8. XM_024448893.1XP_024304661.1  serine/threonine-protein kinase 38-like isoform X1

    Conserved Domains (1) summary
    cd05627
    Location:87509
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
  9. XM_024448896.1XP_024304664.1  serine/threonine-protein kinase 38-like isoform X2

  10. XM_024448890.1XP_024304658.1  serine/threonine-protein kinase 38-like isoform X1

    Conserved Domains (1) summary
    cd05627
    Location:87509
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
  11. XM_024448894.1XP_024304662.1  serine/threonine-protein kinase 38-like isoform X2

  12. XM_024448895.1XP_024304663.1  serine/threonine-protein kinase 38-like isoform X2

  13. XM_011520613.2XP_011518915.1  serine/threonine-protein kinase 38-like isoform X5

    See identical proteins and their annotated locations for XP_011518915.1

    UniProtKB/Swiss-Prot
    Q9Y2H1
    Conserved Domains (2) summary
    smart00220
    Location:10290
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:10359
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001748626.1 RNA Sequence

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