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Npr2 natriuretic peptide receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 230103, updated on 8-Dec-2022

Summary

Official Symbol
Npr2provided by MGI
Official Full Name
natriuretic peptide receptor 2provided by MGI
Primary source
MGI:MGI:97372
See related
Ensembl:ENSMUSG00000028469 AllianceGenome:MGI:97372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cn; pwe; GC-B; GC-B2; GC-B3; mNPR-B
Summary
Enables guanylate cyclase activity; identical protein binding activity; and natriuretic peptide receptor activity. Acts upstream of or within several processes, including bone development; negative regulation of meiotic cell cycle; and negative regulation of oocyte maturation. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Used to study achondroplasia; acromesomelic dysplasia, Maroteaux type; and bone development disease. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 38.6), lung adult (RPKM 29.1) and 22 other tissues See more
Orthologs
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Genomic context

See Npr2 in Genome Data Viewer
Location:
4 A5; 4 23.05 cM
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43629015..43651437)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43629015..43651437)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RAB6A GEF compex partner 1 Neighboring gene microseminoprotein, prostate associated Neighboring gene predicted gene, 42279 Neighboring gene sperm associated antigen 8 Neighboring gene histidine triad nucleotide binding protein 2 Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene family with sequence similarity 221, member B Neighboring gene small EDRK-rich factor 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
achondroplasia
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables natriuretic peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables natriuretic peptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables natriuretic peptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of meiosis involved in egg activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis involved in innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood circulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bone growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in c-di-GMP signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cGMP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cGMP IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to peptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in collateral sprouting IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cumulus cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endochondral ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female genitalia development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gastric emptying IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in growth plate cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymph vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle process involved in oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor guanylyl cyclase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in renal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to fibroblast growth factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hormone IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to luteinizing hormone IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to salt IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in single fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vacuole organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vestibulocochlear nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vestibulocochlear nerve maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in white fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
atrial natriuretic peptide receptor 2
Names
ANP-B
ANPR-B
NPR-B
Nppb receptor
atrial natriuretic peptide receptor type B
guanylate cyclase B
guanylyl cyclase-B
natriuretic peptide receptor B type
NP_001342395.1
NP_776149.1
XP_036019883.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355466.1NP_001342395.1  atrial natriuretic peptide receptor 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AL732626, BE646739, BF469229, CB246804, CJ065677, CK623561, CK624702, CN529877, CO425573, EH106384
    UniProtKB/TrEMBL
    A0A6P7QVB1
    Conserved Domains (4) summary
    smart00044
    Location:800984
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:486767
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam07701
    Location:773821
    HNOBA; Heme NO binding associated
    cd06384
    Location:26421
    PBP1_NPR_B; ligand-binding domain of type B natriuretic peptide receptor
  2. NM_173788.4NP_776149.1  atrial natriuretic peptide receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_776149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL732626, BE646739, BF469229, CB246804, CK623561, CK624702, CN529877, CO425573, EH106384
    Consensus CDS
    CCDS18105.1
    UniProtKB/Swiss-Prot
    Q6VVW5, Q8CGA9
    UniProtKB/TrEMBL
    A0A6P5PIS1
    Related
    ENSMUSP00000030191.9, ENSMUST00000030191.15
    Conserved Domains (4) summary
    smart00044
    Location:8251009
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:518792
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam07701
    Location:798846
    HNOBA; Heme NO binding associated
    cd06384
    Location:26421
    PBP1_NPR_B; ligand-binding domain of type B natriuretic peptide receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43629015..43651437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163990.1XP_036019883.1  atrial natriuretic peptide receptor 2 isoform X1

    Related
    ENSMUSP00000114385.2, ENSMUST00000128549.3
    Conserved Domains (3) summary
    smart00044
    Location:357541
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:50324
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam07701
    Location:330378
    HNOBA; Heme NO binding associated

RNA

  1. XR_390318.5 RNA Sequence