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Nol6 nucleolar protein family 6 (RNA-associated) [ Mus musculus (house mouse) ]

Gene ID: 230082, updated on 5-Mar-2024

Summary

Official Symbol
Nol6provided by MGI
Official Full Name
nucleolar protein family 6 (RNA-associated)provided by MGI
Primary source
MGI:MGI:2140151
See related
Ensembl:ENSMUSG00000028430 AllianceGenome:MGI:2140151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nrap
Summary
Predicted to enable RNA binding activity. Predicted to be involved in rRNA processing and tRNA export from nucleus. Located in condensed nuclear chromosome and nucleolus. Is expressed in several structures, including gut; liver; lung; spleen; and testis. Orthologous to human NOL6 (nucleolar protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 36.7), ovary adult (RPKM 27.9) and 28 other tissues See more
Orthologs
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Genomic context

See Nol6 in Genome Data Viewer
Location:
4 A5; 4 20.98 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41114427..41124450, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41114427..41124339, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25637 Neighboring gene STARR-seq mESC enhancer starr_10018 Neighboring gene aquaporin 3 Neighboring gene STARR-positive B cell enhancer ABC_E150 Neighboring gene STARR-positive B cell enhancer ABC_E6162 Neighboring gene ubiquitin-conjugating enzyme E2R 2 Neighboring gene STARR-seq mESC enhancer starr_10025 Neighboring gene ubiquitin-associated protein 2 Neighboring gene predicted gene, 22888

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of CURI complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of UTP-C complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139236.4NP_631982.2  nucleolar protein 6

    See identical proteins and their annotated locations for NP_631982.2

    Status: VALIDATED

    Source sequence(s)
    AL954379
    Consensus CDS
    CCDS38715.1
    UniProtKB/Swiss-Prot
    Q3TL75, Q3U1P8, Q6PAN8, Q8C6V4, Q8R5K3, Q8R5K4, Q8VCG0, Q8WTY7
    Related
    ENSMUSP00000030138.9, ENSMUST00000030138.9
    Conserved Domains (1) summary
    pfam03813
    Location:1741144
    Nrap; Nrap protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41114427..41124450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941860.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_139237.1: Suppressed sequence

    Description
    NM_139237.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.