Nol6 nucleolar protein family 6 (RNA-associated) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nol6provided by MGI
Official Full Name: nucleolar protein family 6 (RNA-associated)provided by MGI
Primary source: MGI:MGI:2140151
See related: Ensembl:ENSMUSG00000028430 AllianceGenome:MGI:2140151
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nrap
Summary: Predicted to enable RNA binding activity. Predicted to be involved in rRNA processing and tRNA export from nucleus. Located in condensed nuclear chromosome and nucleolus. Is expressed in several structures, including gut; liver; lung; spleen; and testis. Orthologous to human NOL6 (nucleolar protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 36.7), ovary adult (RPKM 27.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 A5

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (41114427..41124450, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (41114427..41124339, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-RAP-s is the predominant spliced form of N-RAP present throughout skeletal muscle development.
Title: Expression and alternative splicing of N-RAP during mouse skeletal muscle development.
The results show that NMHC IIB knockdown led to decreased N-RAP levels through proteasome-mediated degradation.
Title: Role of nonmuscle myosin IIB and N-RAP in cell spreading and myofibril assembly in primary mouse cardiomyocytes.
three new N-RAP binding partners: alpha-actinin, filamin-2, and Krp1 (also called sarcosin) in myofibril assembly
Title: New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected by yeast two-hybrid screening: implications for myofibril assembly.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237465

RH124927 (e-PCR)
- UniSTS:161749

Homology

Homologs of the Nol6 gene: The Nol6 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 501 organisms have orthologs with human gene Nol6
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in tRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of CURI complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of UTP-C complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: nucleolar protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139236.3 → NP_631982.2 nucleolar protein 6

See identical proteins and their annotated locations for NP_631982.2

Status: VALIDATED

Source sequence(s)

BC059820, CN459855

Consensus CDS

CCDS38715.1

UniProtKB/Swiss-Prot

Q8R5K4, Q8WTY7

Related

ENSMUSP00000030138.9, ENSMUST00000030138.9

Conserved Domains (1) summary

pfam03813
Location:174 → 1144

Nrap; Nrap protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

41114427..41124450 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

RNA

XR_004941860.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_139237.1: Suppressed sequence

Description

NM_139237.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.