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KLHDC10 kelch domain containing 10 [ Homo sapiens (human) ]

Gene ID: 23008, updated on 5-Jul-2025
Official Symbol
KLHDC10provided by HGNC
Official Full Name
kelch domain containing 10provided by HGNC
Primary source
HGNC:HGNC:22194
See related
Ensembl:ENSG00000128607 MIM:615152; AllianceGenome:HGNC:22194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
slim; PNAS-138
Summary
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in rescue of stalled ribosome and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Is active in Cul2-RING ubiquitin ligase complex and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in testis (RPKM 13.1), thyroid (RPKM 12.0) and 25 other tissues See more
Orthologs
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See KLHDC10 in Genome Data Viewer
Location:
7q32.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (130070534..130135705)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (131383894..131449088)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129710374..129775545)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr7:129606459-129606647 Neighboring gene UBE2H divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129608210-129608852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129608853-129609494 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129630785-129631284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129646338-129646838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129646839-129647339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26639 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:129649077-129650276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26640 Neighboring gene RNA, 5S ribosomal pseudogene 245 Neighboring gene zinc finger C3HC-type containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129690548-129691340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26644 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129780805-129781468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129781469-129782132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18643 Neighboring gene long intergenic non-protein coding RNA 3008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18644 Neighboring gene transmembrane protein 209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26649 Neighboring gene uncharacterized LOC124901745

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • KIAA0265

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
kelch domain-containing protein 10
Names
PNAS-119
scruin like at the midline homolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014997.4NP_055812.1  kelch domain-containing protein 10

    See identical proteins and their annotated locations for NP_055812.1

    Status: VALIDATED

    Source sequence(s)
    AC087071, BC036464, BC044884, D87454
    Consensus CDS
    CCDS5815.1
    UniProtKB/Swiss-Prot
    Q6PID8, Q86Y99, Q92554
    Related
    ENSP00000334140.4, ENST00000335420.10
    Conserved Domains (4) summary
    PLN02153
    Location:139302
    PLN02153; epithiospecifier protein
    PRK14131
    Location:88171
    PRK14131; N-acetylneuraminate epimerase
    sd00038
    Location:208256
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:315361
    Kelch_1; Kelch motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    130070534..130135705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420061.1XP_047276017.1  kelch domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    Q96G43
  2. XM_047420062.1XP_047276018.1  kelch domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    Q96G43
  3. XM_047420063.1XP_047276019.1  kelch domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    Q96G43
  4. XM_005250233.6XP_005250290.1  kelch domain-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_005250290.1

    Conserved Domains (4) summary
    PLN02153
    Location:110273
    PLN02153; epithiospecifier protein
    PRK14131
    Location:59142
    PRK14131; N-acetylneuraminate epimerase
    sd00038
    Location:179227
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:286332
    Kelch_1; Kelch motif

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    131383894..131449088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357640.1XP_054213615.1  kelch domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    Q96G43
  2. XM_054357641.1XP_054213616.1  kelch domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    Q96G43
  3. XM_054357642.1XP_054213617.1  kelch domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    Q96G43
  4. XM_054357639.1XP_054213614.1  kelch domain-containing protein 10 isoform X1