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KLHDC10 kelch domain containing 10 [ Homo sapiens (human) ]

Gene ID: 23008, updated on 9-Jul-2021

Summary

Official Symbol
KLHDC10provided by HGNC
Official Full Name
kelch domain containing 10provided by HGNC
Primary source
HGNC:HGNC:22194
See related
Ensembl:ENSG00000128607 MIM:615152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
slim
Expression
Ubiquitous expression in testis (RPKM 13.1), thyroid (RPKM 12.0) and 25 other tissues See more
Orthologs
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Genomic context

See KLHDC10 in Genome Data Viewer
Location:
7q32.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (130070532..130135705)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129710374..129775545)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 H Neighboring gene RNA, 5S ribosomal pseudogene 245 Neighboring gene zinc finger C3HC-type containing 1 Neighboring gene uncharacterized LOC100128325 Neighboring gene transmembrane protein 209 Neighboring gene serine rich single-pass membrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0265

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
kelch domain-containing protein 10
Names
PNAS-119
scruin like at the midline homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014997.4NP_055812.1  kelch domain-containing protein 10

    See identical proteins and their annotated locations for NP_055812.1

    Status: VALIDATED

    Source sequence(s)
    AC087071, BC036464, BC044884, D87454
    Consensus CDS
    CCDS5815.1
    UniProtKB/Swiss-Prot
    Q6PID8
    Related
    ENSP00000334140.4, ENST00000335420.10
    Conserved Domains (4) summary
    PLN02153
    Location:139302
    PLN02153; epithiospecifier protein
    PRK14131
    Location:88171
    PRK14131; N-acetylneuraminate epimerase
    sd00038
    Location:208256
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:315361
    Kelch_1; Kelch motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    130070532..130135705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250233.5XP_005250290.1  kelch domain-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_005250290.1

    Conserved Domains (4) summary
    PLN02153
    Location:110273
    PLN02153; epithiospecifier protein
    PRK14131
    Location:59142
    PRK14131; N-acetylneuraminate epimerase
    sd00038
    Location:179227
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:286332
    Kelch_1; Kelch motif
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