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PLCH1 phospholipase C eta 1 [ Homo sapiens (human) ]

Gene ID: 23007, updated on 5-Aug-2018

Summary

Official Symbol
PLCH1provided by HGNC
Official Full Name
phospholipase C eta 1provided by HGNC
Primary source
HGNC:HGNC:29185
See related
Ensembl:ENSG00000114805 MIM:612835; Vega:OTTHUMG00000158477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLCL3
Summary
PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]
Expression
Biased expression in testis (RPKM 4.0), thyroid (RPKM 1.7) and 9 other tissues See more
Orthologs

Genomic context

See PLCH1 in Genome Data Viewer
Location:
3q25.31
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (155458603..155745724, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (155197670..155462878, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene DTW domain containing 1 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 715, pseudogene Neighboring gene PLCH1 antisense RNA 2 Neighboring gene ribosomal protein L6 pseudogene 7 Neighboring gene ribosomal protein L7a pseudogene 24 Neighboring gene chromosome 3 open reading frame 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117152, DKFZp434C1372

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol phospholipase C activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
Names
PLC eta 1
PLC-L3
phosphoinositide phospholipase C-eta-1
phospholipase C-eta1a
phospholipase C-eta1b
phospholipase C-like 3
phospholipase C-like protein 3
NP_001124432.1
NP_001124433.1
NP_001336179.1
NP_001336180.1
NP_001336181.1
NP_055811.2
XP_005247295.1
XP_005247296.1
XP_011510862.1
XP_011510863.1
XP_011510864.1
XP_011510866.1
XP_011510867.1
XP_011510868.1
XP_011510869.1
XP_016861412.1
XP_016861414.1
XP_016861415.1
XP_016861416.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130960.1NP_001124432.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform a

    See identical proteins and their annotated locations for NP_001124432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK096620, AY691171, BC113950, DA206803
    Consensus CDS
    CCDS46939.1
    UniProtKB/Swiss-Prot
    Q4KWH8
    Related
    ENSP00000345988.7, OTTHUMP00000212980, ENST00000340059.11, OTTHUMT00000351125
    Conserved Domains (8) summary
    cd00275
    Location:731855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:298701
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:227872
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:146212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:227298
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:147208
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:441542
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:22128
    PH-like; Pleckstrin homology-like domain
  2. NM_001130961.1NP_001124433.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform c

    See identical proteins and their annotated locations for NP_001124433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform c.
    Source sequence(s)
    AK096620, AY691170, BC113950, DA206803
    Consensus CDS
    CCDS46940.1
    UniProtKB/Swiss-Prot
    Q4KWH8
    Related
    ENSP00000402759.2, OTTHUMP00000212979, ENST00000447496.6, OTTHUMT00000351124
    Conserved Domains (4) summary
    cd08632
    Location:298701
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:146286
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:22128
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:273841
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
  3. NM_001349250.1NP_001336179.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform c.
    Source sequence(s)
    AC012022, AC132006
    Consensus CDS
    CCDS46940.1
    Related
    ENSP00000419100.1, ENST00000494598.5
    Conserved Domains (4) summary
    cd08632
    Location:298701
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:146286
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:22128
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:273841
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
  4. NM_001349251.1NP_001336180.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes isoform d.
    Source sequence(s)
    AC012022, AC104472, AC132006
    Conserved Domains (4) summary
    cd08632
    Location:310713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34140
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:285853
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
  5. NM_001349252.1NP_001336181.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes isoform e.
    Source sequence(s)
    AC012022, AC104472, AC132006
    Conserved Domains (4) summary
    cd08632
    Location:310713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34140
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:285853
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
  6. NM_014996.3NP_055811.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform b.
    Source sequence(s)
    AB028992, AC012022, AC132006, BC113950
    Consensus CDS
    CCDS33881.2
    Related
    ENSP00000335469.6, ENST00000334686.6
    Conserved Domains (4) summary
    cd08632
    Location:310713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34140
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:285853
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    155458603..155745724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005927.1XP_016861416.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

  2. XM_011512562.3XP_011510864.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_011510864.1

    Conserved Domains (8) summary
    cd00275
    Location:743867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:239884
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:158224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:239310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:159220
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:453554
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:34140
    PH-like; Pleckstrin homology-like domain
  3. XM_017005925.1XP_016861414.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4

  4. XM_017005923.1XP_016861412.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2

  5. XM_005247238.1XP_005247295.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_005247295.1

    Conserved Domains (8) summary
    cd00275
    Location:743867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:239884
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:158224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:239310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:159220
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:453554
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:34140
    PH-like; Pleckstrin homology-like domain
  6. XM_011512567.1XP_011510869.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8

    Conserved Domains (4) summary
    cd08632
    Location:310713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34140
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:285853
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
  7. XM_011512560.3XP_011510862.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_011510862.1

    Conserved Domains (8) summary
    cd00275
    Location:743867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:239884
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:158224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:239310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:159220
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:453554
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:34140
    PH-like; Pleckstrin homology-like domain
  8. XM_011512561.2XP_011510863.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_011510863.1

    Conserved Domains (8) summary
    cd00275
    Location:743867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:239884
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:158224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:239310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:159220
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:453554
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:34140
    PH-like; Pleckstrin homology-like domain
  9. XM_005247239.1XP_005247296.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6

    Conserved Domains (7) summary
    cd00275
    Location:731855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:298701
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd00051
    Location:146212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:227298
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:147208
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:441542
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:22128
    PH-like; Pleckstrin homology-like domain
  10. XM_011512565.2XP_011510867.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

    See identical proteins and their annotated locations for XP_011510867.1

    Conserved Domains (8) summary
    cd00275
    Location:713837
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:280683
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:209854
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:128194
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:209280
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:129190
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:423524
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:4110
    PH-like; Pleckstrin homology-like domain
  11. XM_011512566.2XP_011510868.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

    See identical proteins and their annotated locations for XP_011510868.1

    Conserved Domains (8) summary
    cd00275
    Location:713837
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:280683
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:209854
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:128194
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:209280
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:129190
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:423524
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:4110
    PH-like; Pleckstrin homology-like domain
  12. XM_017005926.1XP_016861415.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

    Conserved Domains (8) summary
    cd00275
    Location:713837
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:280683
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:209854
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:128194
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:209280
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:129190
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:423524
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:4110
    PH-like; Pleckstrin homology-like domain
  13. XM_011512564.2XP_011510866.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3

    Related
    ENSP00000417502.2, ENST00000460012.6
    Conserved Domains (4) summary
    cd08632
    Location:310713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34140
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:285853
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
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