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Coq3 coenzyme Q3 methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 230027, updated on 8-Feb-2024

Summary

Official Symbol
Coq3provided by MGI
Official Full Name
coenzyme Q3 methyltransferaseprovided by MGI
Primary source
MGI:MGI:101813
See related
Ensembl:ENSMUSG00000028247 AllianceGenome:MGI:101813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732433J24
Summary
Predicted to enable O-methyltransferase activity and hexaprenyldihydroxybenzoate methyltransferase activity. Predicted to be involved in several processes, including glycerol metabolic process; regulation of ubiquinone biosynthetic process; and ubiquinone biosynthetic process. Located in mitochondrion. Orthologous to human COQ3 (coenzyme Q3, methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 5.7), placenta adult (RPKM 4.2) and 28 other tissues See more
Orthologs
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Genomic context

See Coq3 in Genome Data Viewer
Location:
4 A3; 4 9.11 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (21879646..21912163)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (21879646..21912163)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09733 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 Neighboring gene ubiquitin specific petidase 45 Neighboring gene RIKEN cDNA 4930528A17 gene Neighboring gene STARR-seq mESC enhancer starr_09734 Neighboring gene PNN interacting serine/arginine-rich Neighboring gene STARR-seq mESC enhancer starr_09735 Neighboring gene STARR-seq mESC enhancer starr_09736 Neighboring gene failed axon connections homolog Neighboring gene WEE1 homolog 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in glycerol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquinone biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquinone biosynthesis complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquinone biosynthesis O-methyltransferase, mitochondrial
Names
2-polyprenyl-6-hydroxyphenol methylase
2-polyprenyl-6-hydroxyphenyl methylase
3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
3-demethylubiquinol 3-O-methyltransferase
3-demethylubiquinone-9 3-methyltransferase
Coenzyme Q (ubiquinone)
DHHB methyltransferase
DHHB-MT
DHHB-MTase
coenzyme Q3 homolog, methyltransferase
dihydroxyhexaprenylbenzoate methyltransferase
hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
polyprenyldihydroxybenzoate methyltransferase
NP_001343277.1
NP_766275.1
XP_036019878.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356348.1NP_001343277.1  ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK028680, AK035318, AL772187
    UniProtKB/TrEMBL
    Q3UQM8
    Conserved Domains (1) summary
    TIGR01983
    Location:38268
    UbiG; ubiquinone biosynthesis O-methyltransferase
  2. NM_172687.2NP_766275.1  ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_766275.1

    Status: VALIDATED

    Source sequence(s)
    AK028680, AL772187, CJ077260
    Consensus CDS
    CCDS18003.1
    UniProtKB/Swiss-Prot
    Q3TCX5, Q6P918, Q8BM28, Q8BMS4
    UniProtKB/TrEMBL
    Q3UQM8
    Related
    ENSMUSP00000029909.3, ENSMUST00000029909.3
    Conserved Domains (2) summary
    TIGR01983
    Location:97327
    UbiG; ubiquinone biosynthesis O-methyltransferase
    pfam08241
    Location:152251
    Methyltransf_11; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    21879646..21912163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163985.1XP_036019878.1  ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q3UQM8
    Conserved Domains (1) summary
    TIGR01983
    Location:38268
    UbiG; ubiquinone biosynthesis O-methyltransferase