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HMGXB3 HMG-box containing 3 [ Homo sapiens (human) ]

Gene ID: 22993, updated on 3-Nov-2018

Summary

Official Symbol
HMGXB3provided by HGNC
Official Full Name
HMG-box containing 3provided by HGNC
Primary source
HGNC:HGNC:28982
See related
Ensembl:ENSG00000113716 Vega:OTTHUMG00000163493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMF; HMGX3
Summary
This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in prostate (RPKM 10.5), testis (RPKM 9.2) and 25 other tissues See more
Orthologs

Genomic context

See HMGXB3 in Genome Data Viewer
Location:
5q32
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (150000606..150053143)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149380169..149432706)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6A Neighboring gene mitochondrial fission factor pseudogene Neighboring gene solute carrier family 26 member 2 Neighboring gene tigger transposable element derived 6 Neighboring gene ribosomal protein S20 pseudogene 4 Neighboring gene enhancer in exon 7 of CSF1R Neighboring gene colony stimulating factor 1 receptor Neighboring gene CSF1R promoter/intronic regulatory region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0194

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
HMG domain-containing protein 3
Names
HMG box domain containing 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021389.1 RefSeqGene

    Range
    5001..57538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001366501.1NP_001353430.1  HMG domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC011382, AC011406
    Conserved Domains (2) summary
    smart00398
    Location:41100
    HMG; high mobility group
    cl26464
    Location:276424
    Atrophin-1; Atrophin-1 family
  2. NM_014983.2NP_055798.2  HMG domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_055798.2

    Status: VALIDATED

    Source sequence(s)
    BC035434, BC051025, BC092520, BM974831, DA324742
    Consensus CDS
    CCDS54935.1
    UniProtKB/Swiss-Prot
    Q12766
    UniProtKB/TrEMBL
    Q562E5
    Related
    ENSP00000421917.1, OTTHUMP00000224091, ENST00000502717.5, OTTHUMT00000373771
    Conserved Domains (1) summary
    smart00398
    Location:41100
    HMG; high mobility group

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    150000606..150053143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714765.3XP_006714828.1  HMG domain-containing protein 3 isoform X1

    Conserved Domains (2) summary
    smart00398
    Location:41100
    HMG; high mobility group
    cl26464
    Location:276424
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_001742043.2 RNA Sequence

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