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HMGXB3 HMG-box containing 3 [ Homo sapiens (human) ]

Gene ID: 22993, updated on 15-Sep-2022

Summary

Official Symbol
HMGXB3provided by HGNC
Official Full Name
HMG-box containing 3provided by HGNC
Primary source
HGNC:HGNC:28982
See related
Ensembl:ENSG00000113716 MIM:619800; AllianceGenome:HGNC:28982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMF; HMGX3
Summary
This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in prostate (RPKM 10.5), testis (RPKM 9.2) and 25 other tissues See more
Orthologs
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Genomic context

See HMGXB3 in Genome Data Viewer
Location:
5q32
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (150000739..150053128)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (150537285..150589675)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149380302..149432691)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 member 2 Neighboring gene tigger transposable element derived 6 Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein S20 pseudogene 4 Neighboring gene colony stimulating factor 1 receptor Neighboring gene enhancer in exon 7 of CSF1R Neighboring gene CSF1R promoter/intronic regulatory region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0194

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
HMG domain-containing protein 3
Names
HMG box domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021389.2 RefSeqGene

    Range
    5002..57391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001366501.2NP_001353430.1  HMG domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC011382, AC011406
    Conserved Domains (2) summary
    smart00398
    Location:41100
    HMG; high mobility group
    cl26464
    Location:276424
    Atrophin-1; Atrophin-1 family
  2. NM_014983.3NP_055798.3  HMG domain-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC011382, AC011406
    Consensus CDS
    CCDS54935.1
    UniProtKB/Swiss-Prot
    Q9UMF4
    Related
    ENSP00000421917.1, ENST00000502717.6
    Conserved Domains (3) summary
    smart00398
    Location:41100
    HMG; high mobility group
    PHA03247
    Location:442590
    PHA03247; large tegument protein UL36; Provisional
    pfam18717
    Location:743863
    CxC4; CxC4 like cysteine cluster associated with KDZ transposases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    150000739..150053128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416963.1XP_047272919.1  HMG domain-containing protein 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    150537285..150589675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)