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Gbp5 guanylate binding protein 5 [ Mus musculus (house mouse) ]

Gene ID: 229898, updated on 8-Feb-2024

Summary

Official Symbol
Gbp5provided by MGI
Official Full Name
guanylate binding protein 5provided by MGI
Primary source
MGI:MGI:2429943
See related
Ensembl:ENSMUSG00000105504 AllianceGenome:MGI:2429943
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gbp5a; 5330409J06Rik
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Involved in positive regulation of cytokine production and positive regulation of innate immune response. Acts upstream of or within cellular response to interferon-gamma and response to bacterium. Located in cytoplasmic vesicle. Orthologous to human GBP5 (guanylate binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 9.1), subcutaneous fat pad adult (RPKM 2.0) and 12 other tissues See more
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Genomic context

See Gbp5 in Genome Data Viewer
Location:
3 H1; 3 66.69 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142202695..142228105)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142496934..142522344)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33189 Neighboring gene STARR-seq mESC enhancer starr_09156 Neighboring gene STARR-positive B cell enhancer mm9_chr3:142138865-142139166 Neighboring gene predicted gene, 54184 Neighboring gene STARR-positive B cell enhancer ABC_E3477 Neighboring gene STARR-positive B cell enhancer ABC_E4602 Neighboring gene guanylate binding protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E3478 Neighboring gene guanylate binding protein 3 Neighboring gene predicted gene, 40158

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytolysis in another organism IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytolysis in another organism IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of AIM2 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-18 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of pyroptosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of pyroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in symbiont cell surface IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanylate-binding protein 5
Names
GBP-5
GTP-binding protein 5
guanine nucleotide-binding protein 5
guanylate nucleotide binding protein 5
muGBP-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153564.2NP_705792.2  guanylate-binding protein 5

    See identical proteins and their annotated locations for NP_705792.2

    Status: PROVISIONAL

    Source sequence(s)
    AC102108, AK030414
    Consensus CDS
    CCDS17877.1
    UniProtKB/Swiss-Prot
    E9QJR4, Q8CFA4, Q8CFA8, Q8CFB4
    UniProtKB/TrEMBL
    Q8BU78
    Related
    ENSMUSP00000087587.3, ENSMUST00000090127.7
    Conserved Domains (3) summary
    pfam02841
    Location:283561
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18281
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:289557
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    142202695..142228105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_212440.1: Suppressed sequence

    Description
    NM_212440.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.