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Rap1gds1 RAP1, GTP-GDP dissociation stimulator 1 [ Mus musculus (house mouse) ]

Gene ID: 229877, updated on 26-Sep-2022

Summary

Official Symbol
Rap1gds1provided by MGI
Official Full Name
RAP1, GTP-GDP dissociation stimulator 1provided by MGI
Primary source
MGI:MGI:2385189
See related
Ensembl:ENSMUSG00000028149 AllianceGenome:MGI:2385189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GDS1
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of endoplasmic reticulum calcium ion concentration; positive regulation of GTPase activity; and positive regulation of mitochondrial calcium ion concentration. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; dorsal root ganglion; glans of male genital tubercle; liver; and retina nuclear layer. Orthologous to human RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 49.1), cortex adult (RPKM 47.6) and 27 other tissues See more
Orthologs
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Genomic context

See Rap1gds1 in Genome Data Viewer
Location:
3; 3 H1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138631658..138781163, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138925897..139075228, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930425O10 gene Neighboring gene tetraspanin 5 Neighboring gene predicted gene, 54195 Neighboring gene synaptic nuclear envelope 1 pseudogene Neighboring gene predicted gene 4862 Neighboring gene sperm tail PG rich repeat containing 2 Neighboring gene predicted gene, 24260

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC18981

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in CAAX-box protein maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiotensin-activated signaling pathway involved in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myosin filament assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of ERK5 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of matrix metallopeptidase secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to statin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular associated smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rap1 GTPase-GDP dissociation stimulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040690.3NP_001035780.1  rap1 GTPase-GDP dissociation stimulator 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
    Consensus CDS
    CCDS51083.1
    UniProtKB/Swiss-Prot
    Q3TU36
    UniProtKB/TrEMBL
    E9Q912, Q3TPS9, Q3TU36
    Related
    ENSMUSP00000096173.3, ENSMUST00000098574.9
    Conserved Domains (4) summary
    smart00185
    Location:346389
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:42264
    PLN03200; cellulose synthase-interactive protein; Provisional
    sd00043
    Location:91116
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:86117
    Arm; Armadillo/beta-catenin-like repeat
  2. NM_001286759.2NP_001273688.1  rap1 GTPase-GDP dissociation stimulator 1 isoform c

    See identical proteins and their annotated locations for NP_001273688.1

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
    Consensus CDS
    CCDS80033.1
    UniProtKB/TrEMBL
    Q3TU36
    Related
    ENSMUSP00000143181.2, ENSMUST00000196280.5
    Conserved Domains (2) summary
    cd00020
    Location:317430
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:91116
    ARM; armadillo repeat [structural motif]
  3. NM_001356388.2NP_001343317.1  rap1 GTPase-GDP dissociation stimulator 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
    Conserved Domains (3) summary
    pfam00514
    Location:86117
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:4471
    ARM; armadillo repeat [structural motif]
    cl26969
    Location:177342
    Vitellogenin_N; Lipoprotein amino terminal region
  4. NM_001411343.1NP_001398272.1  rap1 GTPase-GDP dissociation stimulator 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
  5. NM_001411344.1NP_001398273.1  rap1 GTPase-GDP dissociation stimulator 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
  6. NM_001411345.1NP_001398274.1  rap1 GTPase-GDP dissociation stimulator 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
  7. NM_001411346.1NP_001398275.1  rap1 GTPase-GDP dissociation stimulator 1 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
  8. NM_001411347.1NP_001398276.1  rap1 GTPase-GDP dissociation stimulator 1 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
  9. NM_001411348.1NP_001398277.1  rap1 GTPase-GDP dissociation stimulator 1 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
  10. NM_001411349.1NP_001398278.1  rap1 GTPase-GDP dissociation stimulator 1 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
  11. NM_001411350.1NP_001398279.1  rap1 GTPase-GDP dissociation stimulator 1 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
  12. NM_145544.4NP_663519.2  rap1 GTPase-GDP dissociation stimulator 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC110574, AC113307, AC119881
    Consensus CDS
    CCDS51082.1
    UniProtKB/TrEMBL
    E9Q6Q4
    Related
    ENSMUSP00000029796.7, ENSMUST00000029796.11
    Conserved Domains (2) summary
    cd00020
    Location:268381
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:4471
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    138631658..138781163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252602.2XP_030108462.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X1

    Conserved Domains (3) summary
    smart00185
    Location:168211
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:173212
    ARM; armadillo repeat [structural motif]
    cl26969
    Location:48213
    Vitellogenin_N; Lipoprotein amino terminal region
  2. XM_036163086.1XP_036018979.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X2

    Conserved Domains (3) summary
    smart00185
    Location:168211
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:179330
    PLN03200; cellulose synthase-interactive protein; Provisional
    sd00043
    Location:173212
    ARM; armadillo repeat [structural motif]
  3. XM_006501428.5XP_006501491.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X1

    See identical proteins and their annotated locations for XP_006501491.1

    Conserved Domains (3) summary
    smart00185
    Location:168211
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:173212
    ARM; armadillo repeat [structural motif]
    cl26969
    Location:48213
    Vitellogenin_N; Lipoprotein amino terminal region
  4. XM_006501429.5XP_006501492.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X1

    See identical proteins and their annotated locations for XP_006501492.1

    Conserved Domains (3) summary
    smart00185
    Location:168211
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:173212
    ARM; armadillo repeat [structural motif]
    cl26969
    Location:48213
    Vitellogenin_N; Lipoprotein amino terminal region
  5. XM_036163087.1XP_036018980.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X3

    Conserved Domains (4) summary
    PLN03200
    Location:42264
    PLN03200; cellulose synthase-interactive protein; Provisional
    sd00043
    Location:91116
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:86117
    Arm; Armadillo/beta-catenin-like repeat
    cl26969
    Location:226393
    Vitellogenin_N; Lipoprotein amino terminal region
  6. XM_036163088.1XP_036018981.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X4

    Conserved Domains (3) summary
    sd00043
    Location:4471
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:86117
    Arm; Armadillo/beta-catenin-like repeat
    cl26969
    Location:177344
    Vitellogenin_N; Lipoprotein amino terminal region