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Cenpe centromere protein E [ Mus musculus (house mouse) ]

Gene ID: 229841, updated on 2-Oct-2018

Summary

Official Symbol
Cenpeprovided by MGI
Official Full Name
centromere protein Eprovided by MGI
Primary source
MGI:MGI:1098230
See related
Ensembl:ENSMUSG00000045328 Vega:OTTMUSG00000054878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kif10; 312kDa; CENP-E; AU019344; BC049989; C530022J18
Expression
Biased expression in CNS E11.5 (RPKM 11.9), liver E14 (RPKM 8.2) and 9 other tissues See more
Orthologs

Genomic context

See Cenpe in Genome Data Viewer
Location:
3 G3; 3 62.55 cM
Exon count:
46
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (135212537..135273540)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (134875527..134936504)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 2 pseudogene Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene predicted gene, 46826 Neighboring gene 3-hydroxybutyrate dehydrogenase, type 2 Neighboring gene solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore binding IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore binding ISO
Inferred from Sequence Orthology
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
attachment of spindle microtubules to kinetochore TAS
Traceable Author Statement
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinetochore assembly ISO
Inferred from Sequence Orthology
more info
 
lateral attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
microtubule plus-end directed mitotic chromosome migration ISO
Inferred from Sequence Orthology
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
mitotic chromosome movement towards spindle pole ISO
Inferred from Sequence Orthology
more info
 
mitotic metaphase plate congression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic metaphase/anaphase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of developmental process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromosome ISO
Inferred from Sequence Orthology
more info
 
chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
PubMed 
condensed chromosome outer kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
condensed nuclear chromosome kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore ISO
Inferred from Sequence Orthology
more info
 
kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule ISO
Inferred from Sequence Orthology
more info
 
microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
midbody ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle midzone ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
spindle midzone ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
centromere-associated protein E
Names
KIF10
N-7 kinesin
cenpe
centromere autoantigen E
centromeric protein E
kinesin 10
kinesin superfamily protein 10
motor domain of KIF10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173762.4NP_776123.3  centromere-associated protein E

    Status: VALIDATED

    Source sequence(s)
    AC104874, AK133445, AY493378, CN534554, CN704540
    Consensus CDS
    CCDS51072.1
    UniProtKB/Swiss-Prot
    Q6RT24
    UniProtKB/TrEMBL
    E9QKK1
    Related
    ENSMUSP00000057938.7, OTTMUSP00000071861, ENSMUST00000062893.11, OTTMUST00000135967
    Conserved Domains (6) summary
    pfam05483
    Location:11001841
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00129
    Location:6336
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:15702128
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02168
    Location:5861436
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01374
    Location:6329
    KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
    pfam06156
    Location:10411119
    DUF972; Protein of unknown function (DUF972)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    135212537..135273540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319565.1XP_017175054.1  centromere-associated protein E isoform X1

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