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Cenpe centromere protein E [ Mus musculus (house mouse) ]

Gene ID: 229841, updated on 8-Dec-2022

Summary

Official Symbol
Cenpeprovided by MGI
Official Full Name
centromere protein Eprovided by MGI
Primary source
MGI:MGI:1098230
See related
Ensembl:ENSMUSG00000045328 AllianceGenome:MGI:1098230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kif10; 312kDa; CENP-E; C530022J18
Summary
Enables kinetochore binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of protein kinase activity; and regulation of mitotic metaphase/anaphase transition. Acts upstream of or within regulation of protein stability and spindle assembly involved in female meiosis I. Located in kinetochore. Part of outer kinetochore. Is expressed in testis and thymus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 11.9), liver E14 (RPKM 8.2) and 9 other tissues See more
Orthologs
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Genomic context

See Cenpe in Genome Data Viewer
Location:
3 G3; 3 62.55 cM
Exon count:
46
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (134918324..134979301)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135212563..135273540)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 2 pseudogene Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene predicted gene, 46826 Neighboring gene 3-hydroxybutyrate dehydrogenase, type 2 Neighboring gene solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinetochore binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinetochore binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule motor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within attachment of spindle microtubules to kinetochore TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kinetochore assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in lateral attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule plus-end directed mitotic chromosome migration ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic chromosome movement towards spindle pole ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic metaphase/anaphase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of developmental process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spindle assembly involved in female meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in condensed chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle midzone ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
centromere-associated protein E
Names
N-7 kinesin
centromere autoantigen E
centromeric protein E
kinesin 10
kinesin superfamily protein 10
motor domain of KIF10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173762.4NP_776123.3  centromere-associated protein E

    Status: VALIDATED

    Source sequence(s)
    AC104874, AK133445, AY493378, CN534554, CN704540
    Consensus CDS
    CCDS51072.1
    UniProtKB/Swiss-Prot
    Q6RT24
    UniProtKB/TrEMBL
    E9QKK1
    Related
    ENSMUSP00000057938.8, ENSMUST00000062893.12
    Conserved Domains (6) summary
    pfam05483
    Location:11001841
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00129
    Location:6336
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:15702128
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02168
    Location:5861436
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01374
    Location:6329
    KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
    pfam06156
    Location:10411119
    DUF972; Protein of unknown function (DUF972)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    134918324..134979301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)