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DIP2C disco interacting protein 2 homolog C [ Homo sapiens (human) ]

Gene ID: 22982, updated on 27-Nov-2024

Summary

Official Symbol
DIP2Cprovided by HGNC
Official Full Name
disco interacting protein 2 homolog Cprovided by HGNC
Primary source
HGNC:HGNC:29150
See related
Ensembl:ENSG00000151240 MIM:611380; AllianceGenome:HGNC:29150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0934
Summary
This gene encodes a member of the disco-interacting protein homolog 2 family. The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in kidney (RPKM 7.7), brain (RPKM 6.6) and 24 other tissues See more
Orthologs
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Genomic context

See DIP2C in Genome Data Viewer
Location:
10p15.3
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (274201..689668, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (267399..686466, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (320141..735608, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger MYND-type containing 11 Neighboring gene uncharacterized LOC107984190 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:294268-295467 Neighboring gene uncharacterized LOC107984191 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:310208-311407 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:315279-315788 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:315789-316297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2892 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:354363-355312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:360487-360986 Neighboring gene RNA, 5S ribosomal pseudogene 298 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:369502-370701 Neighboring gene uncharacterized LOC124902362 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:390524-391723 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:409736-410935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:415094-416033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:418775-419282 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:461462-462661 Neighboring gene RNA, 7SL, cytoplasmic 754, pseudogene Neighboring gene nonconserved acetylation island sequence 51 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:537143-537670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:545619-546565 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:552897-553476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:560455-560955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:569578-570078 Neighboring gene NANOG hESC enhancer GRCh37_chr10:579126-579627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:587680-588180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:602477-603050 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:603051-603624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:616513-617372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:617373-618230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:665809-666308 Neighboring gene uncharacterized LOC124902361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:671345-672137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:672138-672929 Neighboring gene uncharacterized LOC101930421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:675079-676038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:678070-679004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:685662-686568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:696476-697298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:709923-710450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:717375-717875 Neighboring gene DIP2C antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:735983-736918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:745902-746402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:746403-746903 Neighboring gene microRNA 5699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:771745-772245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:791683-792184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:792185-792684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:805871-806370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:833618-834539 Neighboring gene HNF4 motif-containing MPRA enhancer 225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:855234-855734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:855735-856235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:860653-861153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:860152-860652 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:879525-879763 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:908856-909700 Neighboring gene La ribonucleoprotein 4B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2063 Neighboring gene keratinocyte proline-rich protein-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:989167-989668 Neighboring gene LARP4B divergent transcript Neighboring gene Sharpr-MPRA regulatory region 2332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1036121-1037016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1050745-1051244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1054558-1055058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1055059-1055559 Neighboring gene GTP binding protein 4 Neighboring gene isopentenyl-diphosphate delta isomerase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls.
EBI GWAS Catalog
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ34444, FLJ44075

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
disco-interacting protein 2 homolog C
Names
DIP2 disco-interacting protein 2 homolog C
DIP2 homolog C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014974.3NP_055789.1  disco-interacting protein 2 homolog C

    See identical proteins and their annotated locations for NP_055789.1

    Status: REVIEWED

    Source sequence(s)
    AB023151, AK311679, AL603831, BC035216, BC048327, BC063313, BX537672, N27959
    Consensus CDS
    CCDS7054.1
    UniProtKB/Swiss-Prot
    B4DPI5, Q5SS78, Q9Y2E4
    Related
    ENSP00000280886.6, ENST00000280886.12
    Conserved Domains (5) summary
    cd05905
    Location:341905
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:317908
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:9761450
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:7120
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:9931545
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    274201..689668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252427.5XP_005252484.1  disco-interacting protein 2 homolog C isoform X4

    Conserved Domains (5) summary
    cd05905
    Location:341905
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:317908
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:9761460
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:7120
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:9931555
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. XM_005252426.4XP_005252483.1  disco-interacting protein 2 homolog C isoform X3

    Conserved Domains (5) summary
    cd05905
    Location:397961
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:373964
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:10321506
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:7176
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:10491601
    AFD_class_I; Adenylate forming domain, Class I superfamily
  3. XM_005252428.5XP_005252485.1  disco-interacting protein 2 homolog C isoform X1

    UniProtKB/TrEMBL
    A0A0U1RQW6
    Related
    ENSP00000489203.1, ENST00000634311.1
    Conserved Domains (5) summary
    cd05905
    Location:397961
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:373964
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:10321516
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:7176
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:10491611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  4. XM_011519432.3XP_011517734.1  disco-interacting protein 2 homolog C isoform X6

    Conserved Domains (4) summary
    cd05905
    Location:234798
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:210801
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:8691353
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:8861448
    AFD_class_I; Adenylate forming domain, Class I superfamily
  5. XM_011519431.3XP_011517733.1  disco-interacting protein 2 homolog C isoform X5

    Conserved Domains (5) summary
    cd05905
    Location:345909
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:321912
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:9801454
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:32124
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:9971549
    AFD_class_I; Adenylate forming domain, Class I superfamily
  6. XM_011519429.4XP_011517731.1  disco-interacting protein 2 homolog C isoform X2

    Conserved Domains (5) summary
    cd05905
    Location:401965
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:377968
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:10361510
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:32180
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:10531605
    AFD_class_I; Adenylate forming domain, Class I superfamily
  7. XM_011519433.4XP_011517735.1  disco-interacting protein 2 homolog C isoform X8

    Conserved Domains (2) summary
    pfam00501
    Location:297781
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:314876
    AFD_class_I; Adenylate forming domain, Class I superfamily
  8. XM_005252430.4XP_005252487.3  disco-interacting protein 2 homolog C isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    267399..686466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365264.1XP_054221239.1  disco-interacting protein 2 homolog C isoform X4

  2. XM_054365262.1XP_054221237.1  disco-interacting protein 2 homolog C isoform X3

  3. XM_054365260.1XP_054221235.1  disco-interacting protein 2 homolog C isoform X1

    UniProtKB/TrEMBL
    A0A0U1RQW6
  4. XM_054365266.1XP_054221241.1  disco-interacting protein 2 homolog C isoform X6

  5. XM_054365259.1XP_054221234.1  disco-interacting protein 2 homolog C isoform X9

  6. XM_054365261.1XP_054221236.1  disco-interacting protein 2 homolog C isoform X2

  7. XM_054365263.1XP_054221238.1  disco-interacting protein 2 homolog C isoform X10

  8. XM_054365265.1XP_054221240.1  disco-interacting protein 2 homolog C isoform X5

  9. XM_054365269.1XP_054221244.1  disco-interacting protein 2 homolog C isoform X8

  10. XM_054365267.1XP_054221242.1  disco-interacting protein 2 homolog C isoform X11

  11. XM_054365268.1XP_054221243.1  disco-interacting protein 2 homolog C isoform X12