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DIP2C disco interacting protein 2 homolog C [ Homo sapiens (human) ]

Gene ID: 22982, updated on 11-Jun-2021

Summary

Official Symbol
DIP2Cprovided by HGNC
Official Full Name
disco interacting protein 2 homolog Cprovided by HGNC
Primary source
HGNC:HGNC:29150
See related
Ensembl:ENSG00000151240 MIM:611380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0934
Summary
This gene encodes a member of the disco-interacting protein homolog 2 family. The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in kidney (RPKM 7.7), brain (RPKM 6.6) and 24 other tissues See more
Orthologs
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Genomic context

See DIP2C in Genome Data Viewer
Location:
10p15.3
Exon count:
43
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (274201..689710, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (320141..735608, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger MYND-type containing 11 Neighboring gene uncharacterized LOC107984190 Neighboring gene uncharacterized LOC107984191 Neighboring gene RNA, 5S ribosomal pseudogene 298 Neighboring gene uncharacterized LOC105376340 Neighboring gene RNA, 7SL, cytoplasmic 754, pseudogene Neighboring gene nonconserved acetylation island sequence 51 enhancer Neighboring gene uncharacterized LOC101930421 Neighboring gene DIP2C antisense RNA 1 Neighboring gene microRNA 5699 Neighboring gene HNF4 motif-containing MPRA enhancer 225 Neighboring gene La ribonucleoprotein 4B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls.
GeneReviews: Not available
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
GeneReviews: Not available
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34444, FLJ44075

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
disco-interacting protein 2 homolog C
Names
DIP2 disco-interacting protein 2 homolog C
DIP2 homolog C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014974.3NP_055789.1  disco-interacting protein 2 homolog C

    See identical proteins and their annotated locations for NP_055789.1

    Status: REVIEWED

    Source sequence(s)
    AB023151, AK311679, AL603831, BC035216, BC048327, BC063313, BX537672, N27959
    Consensus CDS
    CCDS7054.1
    UniProtKB/Swiss-Prot
    Q9Y2E4
    UniProtKB/TrEMBL
    Q86XV3
    Related
    ENSP00000280886.6, ENST00000280886.12
    Conserved Domains (5) summary
    cd05905
    Location:341905
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:317908
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:9761450
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:7120
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:9931545
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    274201..689710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252428.4XP_005252485.1  disco-interacting protein 2 homolog C isoform X2

    UniProtKB/TrEMBL
    A0A0U1RQW6
    Related
    ENSP00000489203.1, ENST00000634311.1
    Conserved Domains (5) summary
    cd05905
    Location:397961
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:373964
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:10321516
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:7176
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:10491611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. XM_005252426.3XP_005252483.1  disco-interacting protein 2 homolog C isoform X4

    Conserved Domains (5) summary
    cd05905
    Location:397961
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:373964
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:10321506
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:7176
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:10491601
    AFD_class_I; Adenylate forming domain, Class I superfamily
  3. XM_011519432.2XP_011517734.1  disco-interacting protein 2 homolog C isoform X8

    Conserved Domains (4) summary
    cd05905
    Location:234798
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:210801
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:8691353
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:8861448
    AFD_class_I; Adenylate forming domain, Class I superfamily
  4. XM_011519431.2XP_011517733.1  disco-interacting protein 2 homolog C isoform X7

    Conserved Domains (5) summary
    cd05905
    Location:345909
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:321912
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:9801454
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:32124
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:9971549
    AFD_class_I; Adenylate forming domain, Class I superfamily
  5. XM_011519430.2XP_011517732.1  disco-interacting protein 2 homolog C isoform X5

    Conserved Domains (5) summary
    cd05905
    Location:345909
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:321912
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:9801464
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:32124
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:9971559
    AFD_class_I; Adenylate forming domain, Class I superfamily
  6. XM_011519428.3XP_011517730.1  disco-interacting protein 2 homolog C isoform X1

    Conserved Domains (5) summary
    cd05905
    Location:401965
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:377968
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:10361520
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:32180
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:10531615
    AFD_class_I; Adenylate forming domain, Class I superfamily
  7. XM_011519429.3XP_011517731.1  disco-interacting protein 2 homolog C isoform X3

    Conserved Domains (5) summary
    cd05905
    Location:401965
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:377968
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:10361510
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:32180
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:10531605
    AFD_class_I; Adenylate forming domain, Class I superfamily
  8. XM_011519433.3XP_011517735.1  disco-interacting protein 2 homolog C isoform X11

    Conserved Domains (2) summary
    pfam00501
    Location:297781
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:314876
    AFD_class_I; Adenylate forming domain, Class I superfamily
  9. XM_017015977.1XP_016871466.1  disco-interacting protein 2 homolog C isoform X9

  10. XM_005252430.3XP_005252487.2  disco-interacting protein 2 homolog C isoform X10

  11. XM_005252427.4XP_005252484.1  disco-interacting protein 2 homolog C isoform X6

    Conserved Domains (5) summary
    cd05905
    Location:341905
    Dip2; Disco-interacting protein 2 (Dip2)
    COG0318
    Location:317908
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:9761460
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:7120
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:9931555
    AFD_class_I; Adenylate forming domain, Class I superfamily
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