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NINL ninein like [ Homo sapiens (human) ]

Gene ID: 22981, updated on 5-Aug-2022

Summary

Official Symbol
NINLprovided by HGNC
Official Full Name
ninein likeprovided by HGNC
Primary source
HGNC:HGNC:29163
See related
Ensembl:ENSG00000101004 MIM:609580; AllianceGenome:HGNC:29163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NLP
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in microtubule anchoring at centrosome. Located in cytosol; intercellular bridge; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 4.4), ovary (RPKM 3.4) and 23 other tissues See more
Orthologs
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Genomic context

See NINL in Genome Data Viewer
Location:
20p11.21
Exon count:
35
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (25452697..25585531, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (25517773..25650553, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (25433333..25566167, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 12, lysophospholipase Neighboring gene uncharacterized LOC105372581 Neighboring gene peptidylprolyl isomerase A pseudogene 2 Neighboring gene GINS complex subunit 1 Neighboring gene Sharpr-MPRA regulatory region 10548 Neighboring gene RNA, U6atac small nuclear 17, pseudogene Neighboring gene N-acetylneuraminic acid phosphatase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11792, KIAA0980, dJ691N24.1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule anchoring at centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318226.2NP_001305155.1  ninein-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC036380, DA448124, DA871028, EU718622
    Consensus CDS
    CCDS82605.1
    UniProtKB/Swiss-Prot
    Q9Y2I6
    Related
    ENSP00000410431.1, ENST00000422516.5
    Conserved Domains (6) summary
    cd00051
    Location:212259
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    TIGR02168
    Location:3411014
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:201259
    EF-hand_7; EF-hand domain pair
    cd16269
    Location:9891000
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:607699
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:9301019
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_025176.6NP_079452.3  ninein-like protein isoform 1

    See identical proteins and their annotated locations for NP_079452.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB023197, BC036380, DA448124, DA871028
    Consensus CDS
    CCDS33452.1
    UniProtKB/Swiss-Prot
    Q9NQE3, Q9Y2I6
    Related
    ENSP00000278886.6, ENST00000278886.11
    Conserved Domains (5) summary
    cd00051
    Location:212259
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:201259
    EF-hand_7; EF-hand domain pair
    cd16269
    Location:13381349
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:607699
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:12791368
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    25452697..25585531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440021.1XP_047295977.1  ninein-like protein isoform X6

  2. XM_047440033.1XP_047295989.1  ninein-like protein isoform X20

  3. XM_047440027.1XP_047295983.1  ninein-like protein isoform X12

  4. XM_011529188.1XP_011527490.1  ninein-like protein isoform X5

    See identical proteins and their annotated locations for XP_011527490.1

    Conserved Domains (3) summary
    COG1196
    Location:11181443
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:398706
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam13499
    Location:198259
    EF-hand_7; EF-hand domain pair
  5. XM_047440022.1XP_047295978.1  ninein-like protein isoform X7

  6. XM_047440026.1XP_047295982.1  ninein-like protein isoform X11

  7. XM_047440020.1XP_047295976.1  ninein-like protein isoform X4

  8. XM_047440025.1XP_047295981.1  ninein-like protein isoform X10

  9. XM_047440019.1XP_047295975.1  ninein-like protein isoform X3

  10. XM_047440023.1XP_047295979.1  ninein-like protein isoform X8

  11. XM_011529189.2XP_011527491.1  ninein-like protein isoform X5

    See identical proteins and their annotated locations for XP_011527491.1

    Conserved Domains (3) summary
    COG1196
    Location:11181443
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:398706
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam13499
    Location:198259
    EF-hand_7; EF-hand domain pair
  12. XM_047440032.1XP_047295988.1  ninein-like protein isoform X19

  13. XM_047440024.1XP_047295980.1  ninein-like protein isoform X9

  14. XM_011529187.3XP_011527489.1  ninein-like protein isoform X2

    Conserved Domains (6) summary
    cd00051
    Location:228275
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00261
    Location:11861408
    Tropomyosin; Tropomyosin
    pfam13499
    Location:217275
    EF-hand_7; EF-hand domain pair
    cd16269
    Location:14211432
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:623715
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:13621451
    GBP_C; Guanylate-binding protein, C-terminal domain
  15. XM_011529186.3XP_011527488.1  ninein-like protein isoform X1

    Conserved Domains (6) summary
    cd00051
    Location:228275
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00261
    Location:11911413
    Tropomyosin; Tropomyosin
    pfam13499
    Location:217275
    EF-hand_7; EF-hand domain pair
    cd16269
    Location:14261437
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:628720
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:13671456
    GBP_C; Guanylate-binding protein, C-terminal domain
  16. XM_011529191.1XP_011527493.1  ninein-like protein isoform X13

    Conserved Domains (5) summary
    cd00051
    Location:53100
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:42100
    EF-hand_7; EF-hand domain pair
    cd16269
    Location:12511262
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:453545
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:11921281
    GBP_C; Guanylate-binding protein, C-terminal domain
  17. XM_047440029.1XP_047295985.1  ninein-like protein isoform X15

  18. XM_047440028.1XP_047295984.1  ninein-like protein isoform X14

  19. XM_047440031.1XP_047295987.1  ninein-like protein isoform X18

  20. XM_047440030.1XP_047295986.1  ninein-like protein isoform X16

  21. XM_011529192.3XP_011527494.1  ninein-like protein isoform X17

    Conserved Domains (3) summary
    cd16269
    Location:10381049
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:240332
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:9791068
    GBP_C; Guanylate-binding protein, C-terminal domain
  22. XM_047440034.1XP_047295990.1  ninein-like protein isoform X23

  23. XM_011529194.3XP_011527496.1  ninein-like protein isoform X21

    Conserved Domains (3) summary
    cd16269
    Location:976987
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:178270
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:9171006
    GBP_C; Guanylate-binding protein, C-terminal domain
  24. XM_047440035.1XP_047295991.1  ninein-like protein isoform X24

  25. XM_011529195.3XP_011527497.1  ninein-like protein isoform X22

    Conserved Domains (3) summary
    cd16269
    Location:919930
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:121213
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:860949
    GBP_C; Guanylate-binding protein, C-terminal domain
  26. XM_017027735.2XP_016883224.1  ninein-like protein isoform X25

    Conserved Domains (2) summary
    cd16269
    Location:785796
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:726815
    GBP_C; Guanylate-binding protein, C-terminal domain
  27. XM_011529198.1XP_011527500.1  ninein-like protein isoform X26

    Conserved Domains (2) summary
    cd16269
    Location:767778
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:708797
    GBP_C; Guanylate-binding protein, C-terminal domain

RNA

  1. XR_007067446.1 RNA Sequence

  2. XR_007067445.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    25517773..25650553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)