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TCF25 transcription factor 25 [ Homo sapiens (human) ]

Gene ID: 22980, updated on 5-Jul-2020

Summary

Official Symbol
TCF25provided by HGNC
Official Full Name
transcription factor 25provided by HGNC
Primary source
HGNC:HGNC:29181
See related
Ensembl:ENSG00000141002 MIM:612326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hulp1; NULP1; FKSG26; PRO2620; hKIAA1049
Summary
TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]
Expression
Ubiquitous expression in thyroid (RPKM 33.1), testis (RPKM 28.8) and 25 other tissues See more
Orthologs

Genomic context

See TCF25 in Genome Data Viewer
Location:
16q24.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (89873592..89911384)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89939994..89977795)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984817 Neighboring gene spire type actin nucleation factor 2 Neighboring gene uncharacterized LOC105371419 Neighboring gene uncharacterized LOC112268179 Neighboring gene melanocortin 1 receptor Neighboring gene tubulin beta 3 class III

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1049

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
heart development NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor 25
Names
TCF-25
nuclear localized protein 1
transcription factor 25 (basic helix-loop-helix)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014972.3NP_055787.1  transcription factor 25

    See identical proteins and their annotated locations for NP_055787.1

    Status: VALIDATED

    Source sequence(s)
    BC011884, BI913551
    Consensus CDS
    CCDS10987.1
    UniProtKB/Swiss-Prot
    Q9BQ70
    Related
    ENSP00000263346.8, ENST00000263346.13
    Conserved Domains (1) summary
    pfam04910
    Location:248588
    Tcf25; Transcriptional repressor TCF25

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    89873592..89911384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522956.2XP_011521258.1  transcription factor 25 isoform X1

    Conserved Domains (1) summary
    pfam04910
    Location:248593
    Tcf25; Transcriptional repressor TCF25
  2. XM_011522957.2XP_011521259.1  transcription factor 25 isoform X3

    Conserved Domains (1) summary
    pfam04910
    Location:248593
    Tcf25; Transcriptional repressor TCF25
  3. XM_011522960.2XP_011521262.1  transcription factor 25 isoform X10

    Conserved Domains (1) summary
    pfam04910
    Location:248593
    Tcf25; Transcriptional repressor TCF25
  4. XM_005256297.2XP_005256354.1  transcription factor 25 isoform X2

    Conserved Domains (1) summary
    pfam04910
    Location:248588
    Tcf25; Transcriptional repressor TCF25
  5. XM_005256298.2XP_005256355.1  transcription factor 25 isoform X4

    Related
    ENSP00000455611.1, ENST00000562256.5
    Conserved Domains (1) summary
    pfam04910
    Location:248588
    Tcf25; Transcriptional repressor TCF25
  6. XM_011522958.2XP_011521260.1  transcription factor 25 isoform X5

    Conserved Domains (1) summary
    pfam04910
    Location:248578
    Tcf25; Transcriptional repressor TCF25
  7. XM_017023049.1XP_016878538.1  transcription factor 25 isoform X11

  8. XM_005256299.2XP_005256356.1  transcription factor 25 isoform X6

    Conserved Domains (1) summary
    pfam04910
    Location:248573
    Tcf25; Transcriptional repressor TCF25
  9. XM_017023048.1XP_016878537.1  transcription factor 25 isoform X9

  10. XM_017023050.1XP_016878539.1  transcription factor 25 isoform X12

  11. XM_011522959.2XP_011521261.1  transcription factor 25 isoform X7

    Conserved Domains (1) summary
    pfam04910
    Location:226571
    Tcf25; Transcriptional repressor TCF25
  12. XM_017023047.1XP_016878536.1  transcription factor 25 isoform X8

  13. XM_017023051.1XP_016878540.1  transcription factor 25 isoform X13

  14. XM_017023052.1XP_016878541.1  transcription factor 25 isoform X14

  15. XM_011522961.3XP_011521263.1  transcription factor 25 isoform X15

    Conserved Domains (1) summary
    pfam04910
    Location:13358
    Tcf25; Transcriptional repressor TCF25
  16. XM_017023054.2XP_016878543.1  transcription factor 25 isoform X16

    Related
    ENSP00000263347.7, ENST00000263347.11
  17. XM_017023056.2XP_016878545.1  transcription factor 25 isoform X18

  18. XM_017023055.2XP_016878544.1  transcription factor 25 isoform X17

  19. XM_017023053.1XP_016878542.1  transcription factor 25 isoform X15

    Conserved Domains (1) summary
    pfam04910
    Location:13358
    Tcf25; Transcriptional repressor TCF25
  20. XM_017023057.1XP_016878546.1  transcription factor 25 isoform X18

  21. XM_017023058.1XP_016878547.1  transcription factor 25 isoform X18

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