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TCF25 transcription factor 25 [ Homo sapiens (human) ]

Gene ID: 22980, updated on 17-Jun-2024

Summary

Official Symbol
TCF25provided by HGNC
Official Full Name
transcription factor 25provided by HGNC
Primary source
HGNC:HGNC:29181
See related
Ensembl:ENSG00000141002 MIM:612326; AllianceGenome:HGNC:29181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hulp1; NULP1; FKSG26; PRO2620; hKIAA1049
Summary
TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]
Expression
Ubiquitous expression in thyroid (RPKM 33.1), testis (RPKM 28.8) and 25 other tissues See more
Orthologs
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Genomic context

See TCF25 in Genome Data Viewer
Location:
16q24.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89873592..89911379)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (95958631..95997624)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89940000..89977787)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89903444-89904066 Neighboring gene spire type actin nucleation factor 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89904067-89904688 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:89913406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89913685-89914304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89914305-89914923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89920364-89920864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89920865-89921365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11425 Neighboring gene uncharacterized LOC112268179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89938758-89939714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89945913-89946582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46826 Neighboring gene Sharpr-MPRA regulatory region 15702 Neighboring gene keratin-associated protein 5-1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89978467-89978968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89978969-89979468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89984039-89984924 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr16:89984925-89985808 and GRCh37_chr16:89985809-89986692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89986693-89987576 Neighboring gene Sharpr-MPRA regulatory region 7867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89991680-89992580 Neighboring gene melanocortin 1 receptor Neighboring gene tubulin beta 3 class III

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1049

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of RQC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RQC complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribosome quality control complex subunit TCF25
Names
TCF-25
nuclear localized protein 1
transcription factor 25 (basic helix-loop-helix)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014972.3NP_055787.1  ribosome quality control complex subunit TCF25

    See identical proteins and their annotated locations for NP_055787.1

    Status: VALIDATED

    Source sequence(s)
    BC011884, BI913551
    Consensus CDS
    CCDS10987.1
    UniProtKB/Swiss-Prot
    Q2MK75, Q9BQ70, Q9UPV3
    Related
    ENSP00000263346.8, ENST00000263346.13
    Conserved Domains (1) summary
    pfam04910
    Location:248588
    Tcf25; Transcriptional repressor TCF25

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    89873592..89911379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    95958631..95997624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)