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FOXD4 forkhead box D4 [ Homo sapiens (human) ]

Gene ID: 2298, updated on 23-Nov-2021

Summary

Official Symbol
FOXD4provided by HGNC
Official Full Name
forkhead box D4provided by HGNC
Primary source
HGNC:HGNC:3805
See related
Ensembl:ENSG00000170122 MIM:601092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKHL9; FOXD4A; FREAC5; FREAC-5
Summary
This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012]
Orthologs
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Genomic context

See FOXD4 in Genome Data Viewer
Location:
9p24.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (116231..118417, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116231..118417, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene PGM5P3 antisense RNA 1 Neighboring gene phosphoglucomutase 5 pseudogene 3 Neighboring gene long intergenic non-protein coding RNA 1388 Neighboring gene uncharacterized LOC105375942 Neighboring gene COBW domain containing 1 Neighboring gene VISTA enhancer hs628

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding, bending ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
forkhead box protein D4
Names
forkhead, Drosophila, homolog-like 9
forkhead-related activator 5
forkhead-related protein FKHL9
forkhead-related transcription factor 5
myeloid factor-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032165.1 RefSeqGene

    Range
    5001..7187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_452

mRNA and Protein(s)

  1. NM_207305.5NP_997188.2  forkhead box protein D4

    See identical proteins and their annotated locations for NP_997188.2

    Status: REVIEWED

    Source sequence(s)
    AL449043
    Consensus CDS
    CCDS34975.1
    UniProtKB/Swiss-Prot
    Q12950
    Related
    ENSP00000371940.2, ENST00000382500.4
    Conserved Domains (1) summary
    pfam00250
    Location:104189
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    116231..118417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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