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AKR7A3 aldo-keto reductase family 7 member A3 [ Homo sapiens (human) ]

Gene ID: 22977, updated on 3-May-2025
Official Symbol
AKR7A3provided by HGNC
Official Full Name
aldo-keto reductase family 7 member A3provided by HGNC
Primary source
HGNC:HGNC:390
See related
Ensembl:ENSG00000162482 MIM:608477; AllianceGenome:HGNC:390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AFAR2
Summary
Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]
Expression
Biased expression in duodenum (RPKM 81.0), small intestine (RPKM 50.3) and 6 other tissues See more
Orthologs
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See AKR7A3 in Genome Data Viewer
Location:
1p36.13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (19274229..19288770, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (19097755..19112298, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (19609067..19615264, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19577931-19578436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19580253-19580754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19580755-19581254 Neighboring gene MRT4 homolog, ribosome maturation factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19595541-19596389 Neighboring gene aldo-keto reductase family 7 like (gene/pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19610121-19610996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19614497-19615319 Neighboring gene uncharacterized LOC124903867 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19615320-19616141 Neighboring gene uncharacterized LOC100506730 Neighboring gene RNA, U6 small nuclear 1099, pseudogene Neighboring gene aldo-keto reductase family 7 member A2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NADP+ binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables aldo-keto reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aldo-keto reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aldo-keto reductase (NADPH) activity TAS
Traceable Author Statement
more info
PubMed 
enables electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in aflatoxin catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aldehyde metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular exosome HDA PubMed 
Preferred Names
aflatoxin B1 aldehyde reductase member 3
Names
AFB1 aldehyde reductase 2
AFB1-AR 2
aflatoxin B1 aldehyde reductase 2
aflatoxin aldehyde reductase
epididymis secretory sperm binding protein
NP_036199.2
XP_011539348.1
XP_047305563.1
XP_054191212.1
XP_054191213.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012067.3NP_036199.2  aflatoxin B1 aldehyde reductase member 3

    See identical proteins and their annotated locations for NP_036199.2

    Status: VALIDATED

    Source sequence(s)
    BC031562, BG747063, BM855386, BM920315
    Consensus CDS
    CCDS193.1
    UniProtKB/Swiss-Prot
    O95154, Q86SR4, Q8IVN6, Q8N5V6, Q8TAX1, Q9NUC3
    UniProtKB/TrEMBL
    A0A384MDN8
    Related
    ENSP00000355377.4, ENST00000361640.5
    Conserved Domains (1) summary
    cd06660
    Location:10318
    Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    19274229..19288770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541046.4XP_011539348.1  aflatoxin B1 aldehyde reductase member 3 isoform X1

    Conserved Domains (2) summary
    cd06660
    Location:10220
    Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
    COG0667
    Location:10270
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
  2. XM_047449607.1XP_047305563.1  aflatoxin B1 aldehyde reductase member 3 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    19097755..19112298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335237.1XP_054191212.1  aflatoxin B1 aldehyde reductase member 3 isoform X1

  2. XM_054335238.1XP_054191213.1  aflatoxin B1 aldehyde reductase member 3 isoform X2