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AKR7A3 aldo-keto reductase family 7 member A3 [ Homo sapiens (human) ]

Gene ID: 22977, updated on 3-Nov-2018

Summary

Official Symbol
AKR7A3provided by HGNC
Official Full Name
aldo-keto reductase family 7 member A3provided by HGNC
Primary source
HGNC:HGNC:390
See related
Ensembl:ENSG00000162482 MIM:608477; Vega:OTTHUMG00000002523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AFAR2
Summary
Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]
Expression
Biased expression in duodenum (RPKM 81.0), small intestine (RPKM 50.3) and 6 other tissues See more
Orthologs

Genomic context

See AKR7A3 in Genome Data Viewer
Location:
1p36.13
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (19274229..19289362, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (19609057..19615280, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene EMC1 antisense RNA 1 Neighboring gene ER membrane protein complex subunit 1 Neighboring gene MRT4 homolog, ribosome maturation factor Neighboring gene aldo-keto reductase family 7 like (gene/pseudogene) Neighboring gene uncharacterized LOC100506730 Neighboring gene RNA, U6 small nuclear 1099, pseudogene Neighboring gene aldo-keto reductase family 7 member A2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alditol:NADP+ 1-oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
aldo-keto reductase (NADP) activity TAS
Traceable Author Statement
more info
 
electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aflatoxin catabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular aldehyde metabolic process TAS
Traceable Author Statement
more info
PubMed 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
aflatoxin B1 aldehyde reductase member 3
Names
AFB1 aldehyde reductase 2
AFB1-AR 2
aflatoxin B1 aldehyde reductase 2
aflatoxin aldehyde reductase
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012067.2NP_036199.2  aflatoxin B1 aldehyde reductase member 3

    See identical proteins and their annotated locations for NP_036199.2

    Status: VALIDATED

    Source sequence(s)
    AA844782, BC031562, BC042420, BG747063, BM855386, BM920315
    Consensus CDS
    CCDS193.1
    UniProtKB/Swiss-Prot
    O95154
    Related
    ENSP00000355377.4, OTTHUMP00000002623, ENST00000361640.4, OTTHUMT00000007166
    Conserved Domains (1) summary
    cd06660
    Location:10318
    Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    19274229..19289362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541046.3XP_011539348.1  aflatoxin B1 aldehyde reductase member 3 isoform X1

    Conserved Domains (2) summary
    cd06660
    Location:10220
    Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
    COG0667
    Location:10270
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
  2. XM_017000714.2XP_016856203.1  aflatoxin B1 aldehyde reductase member 3 isoform X2

RNA

  1. XR_001737055.1 RNA Sequence

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