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TPX2 TPX2 microtubule nucleation factor [ Homo sapiens (human) ]

Gene ID: 22974, updated on 24-Nov-2020

Summary

Official Symbol
TPX2provided by HGNC
Official Full Name
TPX2 microtubule nucleation factorprovided by HGNC
Primary source
HGNC:HGNC:1249
See related
Ensembl:ENSG00000088325 MIM:605917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1
Expression
Broad expression in testis (RPKM 19.8), bone marrow (RPKM 18.0) and 16 other tissues See more
Orthologs

Genomic context

See TPX2 in Genome Data Viewer
Location:
20q11.21
Exon count:
18
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (31739248..31801802)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30326904..30389605)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene BCL2 like 1 Neighboring gene BCL2L1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 251 Neighboring gene apoptotic BCL2L1-antisense long non-coding RNA Neighboring gene myosin light chain kinase 2 Neighboring gene dual specificity phosphatase 15 Neighboring gene forkhead box S1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
importin-alpha family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
microtubule nucleation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of microtubule depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of mitotic spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
axon hillock IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
 
nuclear microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
spindle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
targeting protein for Xklp2
Names
TPX2, microtubule-associated protein homolog
TPX2, microtubule-associated, homolog
differentially expressed in cancerous and non-cancerous lung cells 2
differentially expressed in lung cells
hepatocellular carcinoma-associated antigen 519
hepatocellular carcinoma-associated antigen 90
preferentially expressed in colorectal cancer
protein fls353
restricted expression proliferation associated protein 100

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012112.5NP_036244.2  targeting protein for Xklp2

    See identical proteins and their annotated locations for NP_036244.2

    Status: VALIDATED

    Source sequence(s)
    AF098158, BC020207, CB960160
    Consensus CDS
    CCDS13190.1
    UniProtKB/Swiss-Prot
    Q9ULW0
    UniProtKB/TrEMBL
    Q643R0
    Related
    ENSP00000300403.6, ENST00000300403.11
    Conserved Domains (3) summary
    pfam06886
    Location:664718
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    31739248..31801802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528699.2XP_011527001.1  targeting protein for Xklp2 isoform X1

    See identical proteins and their annotated locations for XP_011527001.1

    UniProtKB/Swiss-Prot
    Q9ULW0
    UniProtKB/TrEMBL
    Q643R0
    Conserved Domains (3) summary
    pfam06886
    Location:664718
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
  2. XM_011528697.2XP_011526999.1  targeting protein for Xklp2 isoform X1

    See identical proteins and their annotated locations for XP_011526999.1

    UniProtKB/Swiss-Prot
    Q9ULW0
    UniProtKB/TrEMBL
    Q643R0
    Conserved Domains (3) summary
    pfam06886
    Location:664718
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
  3. XM_011528700.3XP_011527002.1  targeting protein for Xklp2 isoform X2

    Conserved Domains (3) summary
    pfam06886
    Location:657711
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
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