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TPX2 TPX2, microtubule nucleation factor [ Homo sapiens (human) ]

Gene ID: 22974, updated on 13-Jan-2019

Summary

Official Symbol
TPX2provided by HGNC
Official Full Name
TPX2, microtubule nucleation factorprovided by HGNC
Primary source
HGNC:HGNC:1249
See related
Ensembl:ENSG00000088325 MIM:605917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1
Expression
Broad expression in testis (RPKM 19.8), bone marrow (RPKM 18.0) and 16 other tissues See more
Orthologs

Genomic context

See TPX2 in Genome Data Viewer
Location:
20q11.21
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (31739101..31801802)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30326904..30389605)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372589 Neighboring gene BCL2 like 1 Neighboring gene apoptotic BCL2L1-antisense long non-coding RNA Neighboring gene myosin light chain kinase 2 Neighboring gene dual specificity phosphatase 15 Neighboring gene forkhead box S1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
    AURKA Activation by TPX2, organism-specific biosystemTPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. ...
  • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora A signaling, organism-specific biosystem
    Aurora A signaling
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Gastric Cancer Network 1, organism-specific biosystem (from WikiPathways)
    Gastric Cancer Network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    PLK1 signaling events, organism-specific biosystem
    PLK1 signaling events
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Phosphorylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Phosphorylation, organism-specific biosystemPhosphorylation of TP53 (p53) at the N-terminal serine residues S15 and S20 plays a critical role in protein stabilization as phosphorylation at these sites interferes with binding of the ubiquitin l...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding TAS
Traceable Author Statement
more info
PubMed 
GTP binding TAS
Traceable Author Statement
more info
PubMed 
importin-alpha family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of mitotic spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
axon hillock IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IDA
Inferred from Direct Assay
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
spindle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
targeting protein for Xklp2
Names
TPX2, microtubule-associated protein homolog
TPX2, microtubule-associated, homolog
differentially expressed in cancerous and non-cancerous lung cells 2
differentially expressed in lung cells
hepatocellular carcinoma-associated antigen 519
hepatocellular carcinoma-associated antigen 90
preferentially expressed in colorectal cancer
protein fls353
restricted expression proliferation associated protein 100

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012112.5NP_036244.2  targeting protein for Xklp2

    See identical proteins and their annotated locations for NP_036244.2

    Status: VALIDATED

    Source sequence(s)
    AF098158, BC020207, CB960160
    Consensus CDS
    CCDS13190.1
    UniProtKB/Swiss-Prot
    Q9ULW0
    UniProtKB/TrEMBL
    Q643R0
    Related
    ENSP00000300403.6, ENST00000300403.10
    Conserved Domains (3) summary
    pfam06886
    Location:664718
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    31739101..31801802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528699.2XP_011527001.1  targeting protein for Xklp2 isoform X1

    See identical proteins and their annotated locations for XP_011527001.1

    UniProtKB/Swiss-Prot
    Q9ULW0
    UniProtKB/TrEMBL
    Q643R0
    Conserved Domains (3) summary
    pfam06886
    Location:664718
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
  2. XM_011528697.2XP_011526999.1  targeting protein for Xklp2 isoform X1

    See identical proteins and their annotated locations for XP_011526999.1

    UniProtKB/Swiss-Prot
    Q9ULW0
    UniProtKB/TrEMBL
    Q643R0
    Conserved Domains (3) summary
    pfam06886
    Location:664718
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
  3. XM_011528700.3XP_011527002.1  targeting protein for Xklp2 isoform X2

    Conserved Domains (3) summary
    pfam06886
    Location:657711
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam09041
    Location:168
    Aurora-A_bind; Aurora-A binding
    pfam12214
    Location:367489
    TPX2_importin; Cell cycle regulated microtubule associated protein
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