U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ahcyl1 S-adenosylhomocysteine hydrolase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 229709, updated on 8-Jan-2023

Summary

Official Symbol
Ahcyl1provided by MGI
Official Full Name
S-adenosylhomocysteine hydrolase-like 1provided by MGI
Primary source
MGI:MGI:2385184
See related
Ensembl:ENSMUSG00000027893 AllianceGenome:MGI:2385184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DCAL; Irbit; Ahcy-rs3; 1110034F20Rik
Summary
Predicted to enable identical protein binding activity. Involved in epithelial fluid transport. Acts upstream of or within several processes, including mRNA polyadenylation; protein export from nucleus; and regulation of ion transport. Located in cytosol and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human AHCYL1 (adenosylhomocysteinase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 80.6), cortex adult (RPKM 64.9) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ahcyl1 in Genome Data Viewer
Location:
3 F2.3; 3 46.83 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107570436..107603876, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107663120..107696560, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene striatin interacting protein 1 Neighboring gene predicted gene 10961 Neighboring gene predicted gene, 52629 Neighboring gene predicted gene, 40121 Neighboring gene colony stimulating factor 1 (macrophage) Neighboring gene uncharacterized LOC118568636

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables adenosylhomocysteinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables adenosylhomocysteinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in S-adenosylmethionine cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial fluid transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA polyadenylation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion-endoplasmic reticulum membrane tethering ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of sodium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of mRNA 3'-end processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of monoatomic anion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of monoatomic ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondria-associated endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
S-adenosylhomocysteine hydrolase-like protein 1
Names
IP3R binding protein released with inositol 1,4,5-trisphosphate
S-adenosyl-L-homocysteine hydrolase 2
S-adenosylhomocysteine hydrolase, related sequence 3
adoHcyase 2
putative adenosylhomocysteinase 2
NP_001344039.1
NP_001344040.1
NP_001344041.1
NP_001344042.1
NP_663517.2
XP_030108450.1
XP_030108451.1
XP_030108452.1
XP_030108453.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357110.1NP_001344039.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122902, AC140786, BQ176498
    UniProtKB/TrEMBL
    A0A6P5PAX0
    Conserved Domains (1) summary
    smart00996
    Location:59482
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  2. NM_001357111.1NP_001344040.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122902, AC140786, BQ176498
    Conserved Domains (1) summary
    cl21454
    Location:2312
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001357112.1NP_001344041.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122902, AC140786, BQ176498
    Conserved Domains (1) summary
    cl21454
    Location:2312
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001357113.1NP_001344042.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122902, AC140786, BQ176498
    Conserved Domains (1) summary
    cl21454
    Location:21288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. NM_145542.4NP_663517.2  S-adenosylhomocysteine hydrolase-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_663517.2

    Status: VALIDATED

    Source sequence(s)
    AB092504, AC122902, AC140786, AK004088, BQ176498, CJ162898
    Consensus CDS
    CCDS38593.1
    UniProtKB/Swiss-Prot
    Q80SW1
    UniProtKB/TrEMBL
    A0A6P5PH54, A0A8C6HHF6
    Related
    ENSMUSP00000029490.9, ENSMUST00000029490.15
    Conserved Domains (1) summary
    smart00996
    Location:106529
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    107570436..107603876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252590.2XP_030108450.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:21288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_030252592.2XP_030108452.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:21288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_030252593.2XP_030108453.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:21288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_030252591.2XP_030108451.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A6P7QSJ6
    Conserved Domains (1) summary
    cl21454
    Location:21288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins