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FOXD1 forkhead box D1 [ Homo sapiens (human) ]

Gene ID: 2297, updated on 12-Jul-2020

Summary

Official Symbol
FOXD1provided by HGNC
Official Full Name
forkhead box D1provided by HGNC
Primary source
HGNC:HGNC:3802
See related
Ensembl:ENSG00000251493 MIM:601091
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKHL8; FREAC4; FREAC-4
Summary
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity. [provided by RefSeq, Apr 2014]
Orthologs

Genomic context

See FOXD1 in Genome Data Viewer
Location:
5q13.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (73446266..73448777, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (72742083..72744352, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2230 Neighboring gene uncharacterized LOC107986383 Neighboring gene long intergenic non-protein coding RNA 1386 Neighboring gene basic transcription factor 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon guidance IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dichotomous subdivision of terminal units involved in ureteric bud branching ISS
Inferred from Sequence or Structural Similarity
more info
 
luteinizing hormone secretion IEA
Inferred from Electronic Annotation
more info
 
metanephric capsule development ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephric capsule specification ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephric nephron development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
nephrogenic mesenchyme development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of kidney development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
forkhead box protein D1
Names
Forkhead, drosophila, homolog-like 8
forkhead-like 8
forkhead-related activator 4
forkhead-related protein FKHL8
forkhead-related transcription factor 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004472.3NP_004463.1  forkhead box protein D1

    See identical proteins and their annotated locations for NP_004463.1

    Status: REVIEWED

    Source sequence(s)
    AC099522, U59832
    Consensus CDS
    CCDS75259.1
    UniProtKB/Swiss-Prot
    Q16676
    Related
    ENSP00000481581.1, ENST00000615637.3
    Conserved Domains (1) summary
    pfam00250
    Location:125211
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    73446266..73448777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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