Format

Send to:

Choose Destination

SCMH1 Scm polycomb group protein homolog 1 [ Homo sapiens (human) ]

Gene ID: 22955, updated on 31-Jul-2021

Summary

Official Symbol
SCMH1provided by HGNC
Official Full Name
Scm polycomb group protein homolog 1provided by HGNC
Primary source
HGNC:HGNC:19003
See related
Ensembl:ENSG00000010803 MIM:616396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Scml3
Expression
Ubiquitous expression in testis (RPKM 14.6), ovary (RPKM 12.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SCMH1 in Genome Data Viewer
Location:
1p34.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (41027202..41242306, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (41492871..41707978, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CTP synthase 1 Neighboring gene SLFNL1 antisense RNA 1 Neighboring gene schlafen like 1 Neighboring gene ribosomal protein L23a pseudogene 17 Neighboring gene ribosomal protein L36a pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 968

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies 20 loci that influence adult height.
GeneReviews: Not available
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in gene silencing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromocenter IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
polycomb protein SCMH1
Names
sex comb on midleg homolog 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031694.3NP_001026864.1  polycomb protein SCMH1 isoform a

    See identical proteins and their annotated locations for NP_001026864.1

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Consensus CDS
    CCDS30688.1
    UniProtKB/Swiss-Prot
    Q96GD3
    Related
    ENSP00000318094.7, ENST00000326197.11
    Conserved Domains (5) summary
    cd09578
    Location:587657
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:31126
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:233357
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:358466
    SLED; SLED domain
    pfam17208
    Location:271324
    RBR; RNA binding Region
  2. NM_001172218.2NP_001165689.1  polycomb protein SCMH1 isoform c

    See identical proteins and their annotated locations for NP_001165689.1

    Status: VALIDATED

    Source sequence(s)
    AF149046, AL606484, BC009752, BC021252
    Consensus CDS
    CCDS53301.1
    UniProtKB/Swiss-Prot
    Q96GD3
    Related
    ENSP00000361677.1, ENST00000372596.5
    Conserved Domains (5) summary
    cd09578
    Location:504574
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:76174
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:172296
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:297405
    SLED; SLED domain
    pfam17208
    Location:210263
    RBR; RNA binding Region
  3. NM_001172219.2NP_001165690.1  polycomb protein SCMH1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AK023124, AL606484, BC021252
    Consensus CDS
    CCDS53304.1
    UniProtKB/Swiss-Prot
    Q96GD3
    UniProtKB/TrEMBL
    B3KMZ7
    Related
    ENSP00000337352.5, ENST00000337495.9
    Conserved Domains (4) summary
    cd09578
    Location:575645
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:578645
    SAM; Sterile alpha motif
    smart00561
    Location:41136
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam12140
    Location:368476
    DUF3588; Protein of unknown function (DUF3588)
  4. NM_001172220.2NP_001165691.1  polycomb protein SCMH1 isoform c

    See identical proteins and their annotated locations for NP_001165691.1

    Status: VALIDATED

    Source sequence(s)
    AL606484, BC021252, BX640721
    Consensus CDS
    CCDS53301.1
    UniProtKB/Swiss-Prot
    Q96GD3
    Related
    ENSP00000354656.5, ENST00000361191.9
    Conserved Domains (5) summary
    cd09578
    Location:504574
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:76174
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:172296
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:297405
    SLED; SLED domain
    pfam17208
    Location:210263
    RBR; RNA binding Region
  5. NM_001172221.3NP_001165692.1  polycomb protein SCMH1 isoform e

    See identical proteins and their annotated locations for NP_001165692.1

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Consensus CDS
    CCDS53302.1
    UniProtKB/Swiss-Prot
    Q96GD3
    Related
    ENSP00000361676.1, ENST00000372595.5
    Conserved Domains (5) summary
    cd09578
    Location:526596
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:76174
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:172296
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:297405
    SLED; SLED domain
    pfam17208
    Location:210263
    RBR; RNA binding Region
  6. NM_001172222.3NP_001165693.1  polycomb protein SCMH1 isoform f

    See identical proteins and their annotated locations for NP_001165693.1

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Consensus CDS
    CCDS53303.1
    UniProtKB/Swiss-Prot
    Q96GD3
    Related
    ENSP00000403974.2, ENST00000456518.3
    Conserved Domains (4) summary
    cd09578
    Location:407477
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:410477
    SAM; Sterile alpha motif
    smart00561
    Location:279
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam12140
    Location:200308
    DUF3588; Protein of unknown function (DUF3588)
  7. NM_001350667.2NP_001337596.1  polycomb protein SCMH1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AF149046, AL110502, AL606484, BC009752, BC021252, BG024566
    Conserved Domains (5) summary
    cd09578
    Location:496566
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:46144
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:142266
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:267375
    SLED; SLED domain
    pfam17208
    Location:180233
    RBR; RNA binding Region
  8. NM_001350668.2NP_001337597.1  polycomb protein SCMH1 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Conserved Domains (5) summary
    cd09578
    Location:397467
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    pfam02820
    Location:467
    MBT; mbt repeat
    pfam12140
    Location:190298
    SLED; SLED domain
    pfam17208
    Location:103156
    RBR; RNA binding Region
    cl26464
    Location:65189
    Atrophin-1; Atrophin-1 family
  9. NM_001394299.1NP_001381228.1  polycomb protein SCMH1 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Conserved Domains (3) summary
    cd09578
    Location:565635
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:31126
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03307
    Location:173359
    PHA03307; transcriptional regulator ICP4; Provisional
  10. NM_001394300.1NP_001381229.1  polycomb protein SCMH1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Conserved Domains (5) summary
    cd09578
    Location:587657
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:31126
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:233357
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:358466
    SLED; SLED domain
    pfam17208
    Location:271324
    RBR; RNA binding Region
  11. NM_001394301.1NP_001381230.1  polycomb protein SCMH1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Conserved Domains (5) summary
    cd09578
    Location:587657
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:31126
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:233357
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:358466
    SLED; SLED domain
    pfam17208
    Location:271324
    RBR; RNA binding Region
  12. NM_001394302.1NP_001381231.1  polycomb protein SCMH1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Conserved Domains (5) summary
    cd09578
    Location:587657
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:31126
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:233357
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:358466
    SLED; SLED domain
    pfam17208
    Location:271324
    RBR; RNA binding Region
  13. NM_001394303.1NP_001381232.1  polycomb protein SCMH1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Conserved Domains (5) summary
    cd09578
    Location:526596
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:76174
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:172296
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:297405
    SLED; SLED domain
    pfam17208
    Location:210263
    RBR; RNA binding Region
  14. NM_001394304.1NP_001381233.1  polycomb protein SCMH1 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Conserved Domains (3) summary
    cd09578
    Location:565635
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:31126
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03307
    Location:173359
    PHA03307; transcriptional regulator ICP4; Provisional
  15. NM_001394305.1NP_001381234.1  polycomb protein SCMH1 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Conserved Domains (3) summary
    cd09578
    Location:565635
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:31126
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03307
    Location:173359
    PHA03307; transcriptional regulator ICP4; Provisional
  16. NM_001394306.1NP_001381235.1  polycomb protein SCMH1 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Conserved Domains (3) summary
    cd09578
    Location:565635
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:31126
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03307
    Location:173359
    PHA03307; transcriptional regulator ICP4; Provisional
  17. NM_001394307.1NP_001381236.1  polycomb protein SCMH1 isoform j

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
    Conserved Domains (5) summary
    cd09578
    Location:540610
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:90188
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:186310
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:311419
    SLED; SLED domain
    pfam17208
    Location:224277
    RBR; RNA binding Region
  18. NM_001394308.1NP_001381237.1  polycomb protein SCMH1 isoform k

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
  19. NM_001394309.1NP_001381238.1  polycomb protein SCMH1 isoform l

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
  20. NM_001394311.1NP_001381240.1  polycomb protein SCMH1 isoform m

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484
  21. NM_012236.4NP_036368.1  polycomb protein SCMH1 isoform b

    See identical proteins and their annotated locations for NP_036368.1

    Status: VALIDATED

    Source sequence(s)
    AF149045, AL606484, BC009752, BC021252
    Consensus CDS
    CCDS461.1
    UniProtKB/Swiss-Prot
    Q96GD3
    Related
    ENSP00000361678.1, ENST00000372597.5
    Conserved Domains (5) summary
    cd09578
    Location:518588
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:90188
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:186310
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:311419
    SLED; SLED domain
    pfam17208
    Location:224277
    RBR; RNA binding Region

RNA

  1. NR_135092.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL110502, AL391730, AL606484

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    41027202..41242306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000712.1XP_016856201.1  polycomb protein SCMH1 isoform X14

  2. XM_017000713.2XP_016856202.1  polycomb protein SCMH1 isoform X15

  3. XM_017000700.1XP_016856189.1  polycomb protein SCMH1 isoform X8

  4. XM_011541033.2XP_011539335.1  polycomb protein SCMH1 isoform X2

    See identical proteins and their annotated locations for XP_011539335.1

    UniProtKB/Swiss-Prot
    Q96GD3
    Conserved Domains (5) summary
    cd09578
    Location:587657
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:31126
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:233357
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:358466
    SLED; SLED domain
    pfam17208
    Location:271324
    RBR; RNA binding Region
  5. XM_017000699.1XP_016856188.1  polycomb protein SCMH1 isoform X6

    UniProtKB/Swiss-Prot
    Q96GD3
    Conserved Domains (5) summary
    cd09578
    Location:526596
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:76174
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:172296
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:297405
    SLED; SLED domain
    pfam17208
    Location:210263
    RBR; RNA binding Region
  6. XM_017000702.1XP_016856191.1  polycomb protein SCMH1 isoform X10

  7. XM_017000703.1XP_016856192.1  polycomb protein SCMH1 isoform X10

  8. XM_024454206.1XP_024309974.1  polycomb protein SCMH1 isoform X7

    Conserved Domains (5) summary
    cd09578
    Location:496566
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:46144
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:142266
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:267375
    SLED; SLED domain
    pfam17208
    Location:180233
    RBR; RNA binding Region
  9. XM_011541043.2XP_011539345.1  polycomb protein SCMH1 isoform X12

    See identical proteins and their annotated locations for XP_011539345.1

    Conserved Domains (4) summary
    cd09578
    Location:419489
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:422489
    SAM; Sterile alpha motif
    pfam02820
    Location:467
    MBT; mbt repeat
    pfam12140
    Location:190298
    DUF3588; Protein of unknown function (DUF3588)
  10. XM_011541034.1XP_011539336.1  polycomb protein SCMH1 isoform X3

    Conserved Domains (2) summary
    smart00561
    Location:41136
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam12140
    Location:368476
    DUF3588; Protein of unknown function (DUF3588)
  11. XM_024454204.1XP_024309972.1  polycomb protein SCMH1 isoform X7

    Conserved Domains (5) summary
    cd09578
    Location:496566
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:46144
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:142266
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:267375
    SLED; SLED domain
    pfam17208
    Location:180233
    RBR; RNA binding Region
  12. XM_011541032.2XP_011539334.1  polycomb protein SCMH1 isoform X1

    See identical proteins and their annotated locations for XP_011539334.1

    Conserved Domains (4) summary
    cd09578
    Location:597667
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:600667
    SAM; Sterile alpha motif
    smart00561
    Location:41136
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam12140
    Location:368476
    DUF3588; Protein of unknown function (DUF3588)
  13. XM_017000711.1XP_016856200.1  polycomb protein SCMH1 isoform X14

  14. XM_017000708.1XP_016856197.1  polycomb protein SCMH1 isoform X13

  15. XM_024454203.1XP_024309971.1  polycomb protein SCMH1 isoform X7

    Conserved Domains (5) summary
    cd09578
    Location:496566
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00561
    Location:46144
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    PHA03247
    Location:142266
    PHA03247; large tegument protein UL36; Provisional
    pfam12140
    Location:267375
    SLED; SLED domain
    pfam17208
    Location:180233
    RBR; RNA binding Region
  16. XM_011541040.2XP_011539342.1  polycomb protein SCMH1 isoform X11

    Conserved Domains (2) summary
    smart00561
    Location:41136
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam12140
    Location:368476
    DUF3588; Protein of unknown function (DUF3588)

RNA

  1. XR_001737053.1 RNA Sequence

  2. XR_001737045.1 RNA Sequence

  3. XR_001737046.1 RNA Sequence

  4. XR_002959757.1 RNA Sequence

  5. XR_001737054.1 RNA Sequence

  6. XR_001737052.1 RNA Sequence

  7. XR_001737051.1 RNA Sequence

  8. XR_002959760.1 RNA Sequence

  9. XR_002959763.1 RNA Sequence

  10. XR_002959762.1 RNA Sequence

  11. XR_002959761.1 RNA Sequence

  12. XR_946584.2 RNA Sequence

Support Center