U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dennd4b DENN domain containing 4B [ Mus musculus (house mouse) ]

Gene ID: 229541, updated on 3-Apr-2024

Summary

Official Symbol
Dennd4bprovided by MGI
Official Full Name
DENN domain containing 4Bprovided by MGI
Primary source
MGI:MGI:2446201
See related
Ensembl:ENSMUSG00000042404 AllianceGenome:MGI:2446201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rab protein signal transduction. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytoplasmic vesicle. Orthologous to human DENND4B (DENN domain containing 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 39.3), thymus adult (RPKM 27.8) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
3 F1; 3 39.21 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90172281..90187972)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90265020..90280665)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90052523-90052632 Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90057967-90058076 Neighboring gene solute carrier family 39 (zinc transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4558 Neighboring gene CREB regulated transcription coactivator 2 Neighboring gene microRNA 7012 Neighboring gene STARR-positive B cell enhancer ABC_E28 Neighboring gene GATA zinc finger domain containing 2B Neighboring gene STARR-seq mESC enhancer starr_08281 Neighboring gene STARR-positive B cell enhancer ABC_E9009 Neighboring gene STARR-seq mESC enhancer starr_08284 Neighboring gene solute carrier family 27 (fatty acid transporter), member 3 Neighboring gene integrator complex subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • mKIAA0476

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in regulation of Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of Rab protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DENN domain-containing protein 4B
Names
DENN/MADD domain containing 4B
brain specific protein 4
brain-specific gene 4 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356483.1NP_001343412.1  DENN domain-containing protein 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119825
    Consensus CDS
    CCDS89660.1
    UniProtKB/Swiss-Prot
    Q3U1Y4, Q6NZJ7, Q6R5M4, Q80TZ2, Q80VU7, Q8CGE6, Q8R0E9
    UniProtKB/TrEMBL
    B9EKY0
    Related
    ENSMUSP00000117354.2, ENSMUST00000129564.8
    Conserved Domains (5) summary
    smart00801
    Location:563636
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:191279
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:813842
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:313497
    DENN; DENN (AEX-3) domain
    pfam13041
    Location:811851
    PPR_2; PPR repeat family
  2. NM_001405414.1NP_001392343.1  DENN domain-containing protein 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119825
    UniProtKB/Swiss-Prot
    Q3U1Y4, Q6NZJ7, Q6R5M4, Q80TZ2, Q80VU7, Q8CGE6, Q8R0E9
  3. NM_001405415.1NP_001392344.1  DENN domain-containing protein 4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119825
  4. NM_201407.4NP_958809.3  DENN domain-containing protein 4B isoform 1

    See identical proteins and their annotated locations for NP_958809.3

    Status: VALIDATED

    Source sequence(s)
    AC119825, AK155638, BC066102
    Consensus CDS
    CCDS38502.2
    UniProtKB/TrEMBL
    A0A0R4J172, B9EKY0
    Related
    ENSMUSP00000096514.4, ENSMUST00000098914.10
    Conserved Domains (5) summary
    smart00801
    Location:574647
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:202290
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:824853
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:324508
    DENN; DENN (AEX-3) domain
    pfam13041
    Location:822862
    PPR_2; PPR repeat family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90172281..90187972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319543.2XP_017175032.1  DENN domain-containing protein 4B isoform X1

    UniProtKB/TrEMBL
    B9EKY0
    Conserved Domains (5) summary
    smart00801
    Location:588661
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:216304
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:838867
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:338522
    DENN; DENN (AEX-3) domain
    pfam13041
    Location:836876
    PPR_2; PPR repeat family
  2. XM_036163054.1XP_036018947.1  DENN domain-containing protein 4B isoform X4

    Conserved Domains (3) summary
    smart00801
    Location:163
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:240269
    PPR; PPR repeat [structural motif]
    pfam13041
    Location:238278
    PPR_2; PPR repeat family

RNA

  1. XR_375516.4 RNA Sequence