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Syt11 synaptotagmin XI [ Mus musculus (house mouse) ]

Gene ID: 229521, updated on 8-Jan-2023

Summary

Official Symbol
Syt11provided by MGI
Official Full Name
synaptotagmin XIprovided by MGI
Primary source
MGI:MGI:1859547
See related
Ensembl:ENSMUSG00000068923 AllianceGenome:MGI:1859547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500004A13Rik; 3632445O20Rik; 5430404N14Rik; 6530420C11Rik
Summary
Enables several functions, including SNARE binding activity; beta-tubulin binding activity; and identical protein binding activity. Involved in several processes, including learning or memory; negative regulation of cytokine production; and negative regulation of transport. Located in several cellular components, including cytoplasmic vesicle; phagocytic cup; and trans-Golgi network. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SYT11 (synaptotagmin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 100.4), cerebellum adult (RPKM 98.9) and 6 other tissues See more
Orthologs
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Genomic context

See Syt11 in Genome Data Viewer
Location:
3 F1; 3 38.96 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88652006..88682466, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88744699..88775159, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene predicted gene, 25820 Neighboring gene Ras-like without CAAX 1 Neighboring gene gon-4-like pseudogene Neighboring gene RIKEN cDNA 1500004A13 gene Neighboring gene gon-4-like (C.elegans) Neighboring gene predicted gene, 23054

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-tubulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion regulated lysosome exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment of vesicle localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of clathrin-coated pit assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of dopamine secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of membrane invagination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of microglial cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to phagocytic vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of phagosome maturation IC
Inferred by Curator
more info
PubMed 
involved_in regulation of phagosome maturation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in dopaminergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dopaminergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in early phagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in inhibitory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
synaptotagmin-11
Names
sytXI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018804.3NP_061274.2  synaptotagmin-11

    See identical proteins and their annotated locations for NP_061274.2

    Status: VALIDATED

    Source sequence(s)
    BC054526, BU056967, BY295190, CD776044, CV561059
    Consensus CDS
    CCDS38484.1
    UniProtKB/Swiss-Prot
    Q7TQG8, Q9R0N3
    Related
    ENSMUSP00000088464.5, ENSMUST00000090945.5
    Conserved Domains (2) summary
    cd08388
    Location:157282
    C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
    cd08404
    Location:291428
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88652006..88682466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501350.4XP_006501413.1  synaptotagmin-11 isoform X2

    See identical proteins and their annotated locations for XP_006501413.1

    UniProtKB/TrEMBL
    Q3TPH5
    Conserved Domains (2) summary
    cd08388
    Location:157282
    C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
    cd08404
    Location:291427
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
  2. XM_006501348.1XP_006501411.1  synaptotagmin-11 isoform X1

    See identical proteins and their annotated locations for XP_006501411.1

    UniProtKB/Swiss-Prot
    Q7TQG8, Q9R0N3
    Related
    ENSMUSP00000103129.2, ENSMUST00000107505.8
    Conserved Domains (2) summary
    cd08388
    Location:157282
    C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
    cd08404
    Location:291428
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
  3. XM_030252576.1XP_030108436.1  synaptotagmin-11 isoform X1

    UniProtKB/Swiss-Prot
    Q7TQG8
    Conserved Domains (2) summary
    cd08388
    Location:157282
    C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
    cd08404
    Location:291428
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
  4. XM_036163052.1XP_036018945.1  synaptotagmin-11 isoform X2

    UniProtKB/TrEMBL
    Q3TPH5
    Related
    ENSMUSP00000138284.2, ENSMUST00000183267.2
    Conserved Domains (2) summary
    cd08388
    Location:157282
    C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
    cd08404
    Location:291427
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4