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PTGR1 prostaglandin reductase 1 [ Homo sapiens (human) ]

Gene ID: 22949, updated on 24-Nov-2020

Summary

Official Symbol
PTGR1provided by HGNC
Official Full Name
prostaglandin reductase 1provided by HGNC
Primary source
HGNC:HGNC:18429
See related
Ensembl:ENSG00000106853 MIM:601274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR1; DIG-1; ZADH3; LTB4DH
Summary
This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Expression
Broad expression in liver (RPKM 118.8), small intestine (RPKM 109.3) and 18 other tissues See more
Orthologs

Genomic context

See PTGR1 in Genome Data Viewer
Location:
9q31.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (111549722..111599855, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (114312002..114362135, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily K member 2 Neighboring gene Ecm29 proteasome adaptor and scaffold Neighboring gene RNA, 5S ribosomal pseudogene 294 Neighboring gene zinc finger protein 483 Neighboring gene leucine rich repeat containing 37 member A5, pseudogene Neighboring gene uncharacterized LOC107987116

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic variation associated with circulating monocyte count in the eMERGE Network.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99229, MGC34943

Gene Ontology Provided by GOA

Function Evidence Code Pubs
13-lipoxin reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
13-prostaglandin reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
15-oxoprostaglandin 13-oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
2-alkenal reductase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
leukotriene B4 12-hydroxy dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
leukotriene B4 metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
leukotriene metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
lipoxin A4 metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
response to antineoplastic agent IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
prostaglandin reductase 1
Names
15-oxoprostaglandin 13-reductase
D3T-inducible gene 1 protein
NAD(P)H-dependent alkenal/one oxidoreductase
NADP-dependent leukotriene B4 12-hydroxydehydrogenase
PRG-1
dithiolethione-inducible gene 1 protein
leukotriene B4 12-hydroxydehydrogenase
zinc binding alcohol dehydrogenase domain containing 3
NP_001139580.1
NP_001139581.1
NP_036344.2
XP_011516696.1
XP_011516697.1
XP_016869974.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146108.2NP_001139580.1  prostaglandin reductase 1 isoform 1

    See identical proteins and their annotated locations for NP_001139580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA876375, AK289597, AL135787
    Consensus CDS
    CCDS6779.1
    UniProtKB/Swiss-Prot
    Q14914
    Related
    ENSP00000385763.2, ENST00000407693.7
    Conserved Domains (2) summary
    TIGR02825
    Location:4328
    B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
    cd08294
    Location:2329
    leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity
  2. NM_001146109.2NP_001139581.1  prostaglandin reductase 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AK298379, AL135787
    Consensus CDS
    CCDS55331.1
    UniProtKB/Swiss-Prot
    Q14914
    Related
    ENSP00000440281.1, ENST00000538962.7
    Conserved Domains (2) summary
    TIGR02825
    Location:4300
    B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
    cd08294
    Location:2295
    leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity
  3. NM_012212.3NP_036344.2  prostaglandin reductase 1 isoform 1

    See identical proteins and their annotated locations for NP_036344.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA876375, AL135787, BC035228
    Consensus CDS
    CCDS6779.1
    UniProtKB/Swiss-Prot
    Q14914
    Related
    ENSP00000311572.5, ENST00000309195.9
    Conserved Domains (2) summary
    TIGR02825
    Location:4328
    B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
    cd08294
    Location:2329
    leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    111549722..111599855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518394.2XP_011516696.1  prostaglandin reductase 1 isoform X1

    Conserved Domains (1) summary
    cd08294
    Location:2253
    leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity
  2. XM_017014485.2XP_016869974.1  prostaglandin reductase 1 isoform X1

    Conserved Domains (1) summary
    cd08294
    Location:2253
    leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity
  3. XM_011518395.3XP_011516697.1  prostaglandin reductase 1 isoform X2

    Conserved Domains (1) summary
    cl16912
    Location:1206
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

RNA

  1. XR_929738.2 RNA Sequence

  2. XR_001746250.2 RNA Sequence

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