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KIN Kin17 DNA and RNA binding protein [ Homo sapiens (human) ]

Gene ID: 22944, updated on 9-Dec-2018

Summary

Official Symbol
KINprovided by HGNC
Official Full Name
Kin17 DNA and RNA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:6327
See related
Ensembl:ENSG00000151657 MIM:601720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTCD; Rts2; KIN17
Summary
The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in endometrium (RPKM 1.8), thyroid (RPKM 1.7) and 25 other tissues See more
Orthologs

Genomic context

See KIN in Genome Data Viewer
Location:
10p14
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (7750962..7788027, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (7792925..7829990, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2566 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 2 Neighboring gene uncharacterized LOC105376392 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene TATA-box binding protein associated factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Protein methylation, organism-specific biosystem (from REACTOME)
    Protein methylation, organism-specific biosystemMethylation of lysine (Lys) and arginine (Arg) residues on non-histone proteins is a prevalent post-translational modification and important regulator of cellular signal transduction pathways includi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
mRNA processing TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA/RNA-binding protein KIN17
Names
KIN, antigenic determinant of recA protein homolog
binding to curved DNA

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012311.4NP_036443.1  DNA/RNA-binding protein KIN17

    See identical proteins and their annotated locations for NP_036443.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AA768850, AJ005273, AK301789, AL158044
    Consensus CDS
    CCDS7080.1
    UniProtKB/Swiss-Prot
    O60870
    Related
    ENSP00000368881.3, ENST00000379562.8
    Conserved Domains (2) summary
    cd13155
    Location:339392
    KOW_KIN17; KOW_Kin17 is a RNA-binding motif
    pfam10357
    Location:55177
    Kin17_mid; Domain of Kin17 curved DNA-binding protein

RNA

  1. NR_045609.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses alternate exon structure at its 3' end, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA768850, AK301789, AL158044

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    7750962..7788027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519427.2XP_011517729.1  DNA/RNA-binding protein KIN17 isoform X2

    See identical proteins and their annotated locations for XP_011517729.1

    UniProtKB/Swiss-Prot
    O60870
    Conserved Domains (2) summary
    pfam10357
    Location:55177
    Kin17_mid; Domain of Kin17 curved DNA-binding protein
    cl00354
    Location:339373
    KOW; KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)
  2. XM_017015946.1XP_016871435.1  DNA/RNA-binding protein KIN17 isoform X4

  3. XM_006717435.4XP_006717498.1  DNA/RNA-binding protein KIN17 isoform X3

    Conserved Domains (2) summary
    pfam10357
    Location:171
    Kin17_mid; Domain of Kin17 curved DNA-binding protein
    cl00354
    Location:233267
    KOW; KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)
  4. XM_006717434.4XP_006717497.1  DNA/RNA-binding protein KIN17 isoform X1

    See identical proteins and their annotated locations for XP_006717497.1

    Conserved Domains (2) summary
    pfam10357
    Location:55177
    Kin17_mid; Domain of Kin17 curved DNA-binding protein
    cl00354
    Location:339373
    KOW; KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)

RNA

  1. XR_930485.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_045610.1: Suppressed sequence

    Description
    NR_045610.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to retain intronic sequence at its 3'' end.
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