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DKK1 dickkopf WNT signaling pathway inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 22943, updated on 8-Jul-2018
Official Symbol
DKK1provided by HGNC
Official Full Name
dickkopf WNT signaling pathway inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:2891
See related
Ensembl:ENSG00000107984 MIM:605189; Vega:OTTHUMG00000018247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SK; DKK-1
Summary
This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]
Expression
Biased expression in placenta (RPKM 39.1), urinary bladder (RPKM 8.2) and 3 other tissues See more
Orthologs
See DKK1 in Genome Data Viewer
Location:
10q21.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (52314183..52317657)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (54074041..54077417)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene protein kinase cGMP-dependent 1 Neighboring gene cleavage stimulation factor subunit 2 tau variant Neighboring gene PRKG1 antisense RNA 1 Neighboring gene ribosomal protein L31 pseudogene 44 Neighboring gene THAP domain containing 12 pseudogene 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
NHGRI GWA Catalog
Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.
NHGRI GWA Catalog
Genome-wide association study of chronic periodontitis in a general German population.
NHGRI GWA Catalog
Several common variants modulate heart rate, PR interval and QRS duration.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of dickkopf-1 in primary human osteoblasts PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
co-receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
co-receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
co-receptor binding TAS
Traceable Author Statement
more info
PubMed 
growth factor activity TAS
Traceable Author Statement
more info
PubMed 
low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor antagonist activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis involved in differentiation IEA
Inferred from Electronic Annotation
more info
 
embryonic limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endoderm formation IEA
Inferred from Electronic Annotation
more info
 
extracellular negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
limb development ISS
Inferred from Sequence or Structural Similarity
more info
 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
modulation of age-related behavioral decline ISS
Inferred from Sequence or Structural Similarity
more info
 
motor learning IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly IPI
Inferred from Physical Interaction
more info
PubMed 
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of canonical Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cardiac muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mesodermal cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell death TAS
Traceable Author Statement
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of midbrain dopaminergic neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
regulation of endodermal cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
regulation of receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
synapse disassembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
early endosome membrane TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
dickkopf-related protein 1
Names
dickkopf 1 homolog
dickkopf-1 like
dickkopf-like protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012242.3NP_036374.1  dickkopf-related protein 1 precursor

    See identical proteins and their annotated locations for NP_036374.1

    Status: REVIEWED

    Source sequence(s)
    AC009986, AF127563, BP265847, BU752259
    Consensus CDS
    CCDS7246.1
    UniProtKB/Swiss-Prot
    O94907
    UniProtKB/TrEMBL
    I1W660
    Related
    ENSP00000363081.3, OTTHUMP00000019617, ENST00000373970.3
    Conserved Domains (1) summary
    pfam04706
    Location:85139
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    52314183..52317657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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