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Gpr149 G protein-coupled receptor 149 [ Mus musculus (house mouse) ]

Gene ID: 229357, updated on 7-May-2024

Summary

Official Symbol
Gpr149provided by MGI
Official Full Name
G protein-coupled receptor 149provided by MGI
Primary source
MGI:MGI:2443628
See related
Ensembl:ENSMUSG00000043441 AllianceGenome:MGI:2443628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
R35; Ieda; PGR10; 9630018L10Rik
Summary
Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Acts upstream of or within antral ovarian follicle growth; negative regulation of ovulation; and preantral ovarian follicle growth. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human GPR149 (G protein-coupled receptor 149). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 1.6), whole brain E14.5 (RPKM 0.6) and 8 other tissues See more
Orthologs
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Genomic context

See Gpr149 in Genome Data Viewer
Location:
3 E1; 3 29.97 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (62436851..62512861, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (62529430..62605440, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07812 Neighboring gene Rho guanine nucleotide exchange factor 26 Neighboring gene predicted gene, 33923 Neighboring gene STARR-seq mESC enhancer starr_07813 Neighboring gene STARR-seq mESC enhancer starr_07814 Neighboring gene DEAH-box helicase 36 Neighboring gene STARR-seq mESC enhancer starr_07815 Neighboring gene STARR-seq mESC enhancer starr_07816 Neighboring gene STARR-seq mESC enhancer starr_07817 Neighboring gene STARR-seq mESC enhancer starr_07818 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene predicted gene, 40062

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 149
Names
G protein-coupled receptor PGR10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356525.1NP_001343454.1  probable G-protein coupled receptor 149 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114424, AC115721
    Conserved Domains (1) summary
    cd15011
    Location:37375
    7tmA_GPR149; G protein-coupled receptor 149, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_177346.5NP_796320.2  probable G-protein coupled receptor 149 isoform 1

    See identical proteins and their annotated locations for NP_796320.2

    Status: VALIDATED

    Source sequence(s)
    AC114424, AC115721
    Consensus CDS
    CCDS17380.1
    UniProtKB/Swiss-Prot
    Q3TMB1, Q3UVY1, Q80T52, Q8BXA3, Q8BZC0
    Related
    ENSMUSP00000060893.6, ENSMUST00000058535.6
    Conserved Domains (1) summary
    pfam00001
    Location:56211
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    62436851..62512861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240076.3XP_011238378.1  probable G-protein coupled receptor 149 isoform X1

    Conserved Domains (1) summary
    cd15011
    Location:37375
    7tmA_GPR149; G protein-coupled receptor 149, member of the class A family of seven-transmembrane G protein-coupled receptors