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Eif2a eukaryotic translation initiation factor 2A [ Mus musculus (house mouse) ]

Gene ID: 229317, updated on 11-Jun-2024

Summary

Official Symbol
Eif2aprovided by MGI
Official Full Name
eukaryotic translation initiation factor 2Aprovided by MGI
Primary source
MGI:MGI:1098684
See related
Ensembl:ENSMUSG00000027810 AllianceGenome:MGI:1098684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D030048D22; D3Ertd194e
Summary
Predicted to enable RNA binding activity and ribosome binding activity. Acts upstream of or within SREBP signaling pathway; cellular protein metabolic process; and positive regulation of signal transduction. Predicted to be located in cytoplasm. Predicted to be part of cytosolic small ribosomal subunit and eukaryotic translation initiation factor 2 complex. Is expressed in brain; early conceptus; lens; liver; and ovary. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 100.7), duodenum adult (RPKM 76.7) and 18 other tissues See more
Orthologs
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Genomic context

See Eif2a in Genome Data Viewer
Location:
3 D; 3 28.58 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (58433252..58464922)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (58525821..58557501)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11710 Neighboring gene predicted gene, 20128 Neighboring gene TSC22 domain family, member 2 Neighboring gene STARR-seq mESC enhancer starr_07749 Neighboring gene STARR-positive B cell enhancer ABC_E1618 Neighboring gene STARR-positive B cell enhancer ABC_E516 Neighboring gene STARR-positive B cell enhancer ABC_E3433 Neighboring gene stress-associated endoplasmic reticulum protein 1 Neighboring gene STARR-seq mESC enhancer starr_07753 Neighboring gene STARR-seq mESC enhancer starr_07754 Neighboring gene STARR-positive B cell enhancer ABC_E9549 Neighboring gene selenoprotein T Neighboring gene glutamate rich 6 Neighboring gene predicted gene, 46806

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC105246

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 2 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 2A
Names
eIF-2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005509.3NP_001005509.1  eukaryotic translation initiation factor 2A isoform 1

    See identical proteins and their annotated locations for NP_001005509.1

    Status: VALIDATED

    Source sequence(s)
    AC119873, AC121794
    Consensus CDS
    CCDS17367.1
    UniProtKB/Swiss-Prot
    Q05C11, Q640P8, Q8BJW6
    Related
    ENSMUSP00000029387.9, ENSMUST00000029387.15
    Conserved Domains (2) summary
    pfam08662
    Location:216411
    eIF2A; Eukaryotic translation initiation factor eIF2A
    cl02567
    Location:41143
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001411292.1NP_001398221.1  eukaryotic translation initiation factor 2A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119873, AC121794
  3. NM_001411293.1NP_001398222.1  eukaryotic translation initiation factor 2A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119873, AC121794

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    58433252..58464922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501321.5XP_006501384.1  eukaryotic translation initiation factor 2A isoform X1

    See identical proteins and their annotated locations for XP_006501384.1

    Conserved Domains (2) summary
    COG5354
    Location:36508
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    pfam08662
    Location:157352
    eIF2A; Eukaryotic translation initiation factor eIF2A
  2. XM_036163037.1XP_036018930.1  eukaryotic translation initiation factor 2A isoform X2

    Conserved Domains (2) summary
    COG5354
    Location:22454
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    pfam08662
    Location:103298
    eIF2A; Eukaryotic translation initiation factor eIF2A