Format

Send to:

Choose Destination

Eif2a eukaryotic translation initiation factor 2A [ Mus musculus (house mouse) ]

Gene ID: 229317, updated on 25-Mar-2019

Summary

Official Symbol
Eif2aprovided by MGI
Official Full Name
eukaryotic translation initiation factor 2Aprovided by MGI
Primary source
MGI:MGI:1098684
See related
Ensembl:ENSMUSG00000027810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D030048D22; D3Ertd194e
Expression
Broad expression in adrenal adult (RPKM 100.7), duodenum adult (RPKM 76.7) and 18 other tissues See more
Orthologs

Genomic context

See Eif2a in Genome Data Viewer
Location:
3 D; 3 28.58 cM
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (58525821..58557501)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (58329743..58361423)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 20128 Neighboring gene TSC22 domain family, member 2 Neighboring gene stress-associated endoplasmic reticulum protein 1 Neighboring gene selenoprotein T Neighboring gene glutamate rich 6 Neighboring gene predicted gene, 46806

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105246

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome binding ISO
Inferred from Sequence Orthology
more info
 
tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA binding ISO
Inferred from Sequence Orthology
more info
 
translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
SREBP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of translation ISO
Inferred from Sequence Orthology
more info
 
response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
ribosome assembly ISO
Inferred from Sequence Orthology
more info
 
translation IDA
Inferred from Direct Assay
more info
PubMed 
translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 2 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 2A
Names
eIF-2A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005509.2NP_001005509.1  eukaryotic translation initiation factor 2A

    See identical proteins and their annotated locations for NP_001005509.1

    Status: VALIDATED

    Source sequence(s)
    BC082557, BY035972
    Consensus CDS
    CCDS17367.1
    UniProtKB/Swiss-Prot
    Q8BJW6
    Related
    ENSMUSP00000029387.8, ENSMUST00000029387.14
    Conserved Domains (2) summary
    pfam08662
    Location:216411
    eIF2A; Eukaryotic translation initiation factor eIF2A
    cl02567
    Location:41143
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    58525821..58557501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501321.3XP_006501384.1  eukaryotic translation initiation factor 2A isoform X1

    See identical proteins and their annotated locations for XP_006501384.1

    Conserved Domains (1) summary
    pfam08662
    Location:157352
    eIF2A; Eukaryotic translation initiation factor eIF2A
Support Center