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HABP4 hyaluronan binding protein 4 [ Homo sapiens (human) ]

Gene ID: 22927, updated on 17-Sep-2024

Summary

Official Symbol
HABP4provided by HGNC
Official Full Name
hyaluronan binding protein 4provided by HGNC
Primary source
HGNC:HGNC:17062
See related
Ensembl:ENSG00000130956 MIM:617369; AllianceGenome:HGNC:17062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IHABP4; IHABP-4; Ki-1/57; SERBP1L
Summary
Enables SUMO binding activity. Involved in PML body organization; negative regulation of DNA binding activity; and positive regulation of gene expression. Located in several cellular components, including Golgi apparatus; cytoplasmic stress granule; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 24.4), testis (RPKM 16.9) and 22 other tissues See more
Orthologs
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Genomic context

See HABP4 in Genome Data Viewer
Location:
9q22.32
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (96450102..96491336)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (108621878..108663114)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (99212451..99253618)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene SLC35D2-HSD17B3 readthrough Neighboring gene solute carrier family 35 member D2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:99105285-99105808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:99104760-99105284 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20078 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110866 Neighboring gene Sharpr-MPRA regulatory region 10311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28652 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20079 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20080 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:99180933-99181466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:99181467-99182000 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:99182517-99183716 Neighboring gene zinc finger protein 367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:99185787-99186288 Neighboring gene NSA2 pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99256389-99257179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99257792-99258292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99273815-99274314 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:99284685-99285884 Neighboring gene cell division cycle 14B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20087 Neighboring gene MPRA-validated peak7299 silencer Neighboring gene uncharacterized LOC105376163 Neighboring gene MPRA-validated peak7301 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:99381276-99381776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20090 Neighboring gene peroxiredoxin like 2C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC825

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SUMO binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables translation elongation factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in PML body organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to mechanical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosome hibernation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in Gemini of coiled bodies IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sarcomere ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sarcoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
intracellular hyaluronan-binding protein 4
Names
chromodomain helicase DNA binding protein 3 interacting protein
intracellular antigen detected by monoclonal antibody Ki-1
ki-1/57 intracellular antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014282.4NP_055097.2  intracellular hyaluronan-binding protein 4

    See identical proteins and their annotated locations for NP_055097.2

    Status: VALIDATED

    Source sequence(s)
    AF241831, AK025144, BC018788, CN287447, DR006985
    Consensus CDS
    CCDS6719.1
    UniProtKB/Swiss-Prot
    O75804, Q5JVS0, Q8WV33, Q9NYJ2
    Related
    ENSP00000364398.4, ENST00000375249.5
    Conserved Domains (2) summary
    pfam04774
    Location:212316
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:16131
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    96450102..96491336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423008.1XP_047278964.1  intracellular hyaluronan-binding protein 4 isoform X3

  2. XM_047423007.1XP_047278963.1  intracellular hyaluronan-binding protein 4 isoform X3

  3. XM_047423006.1XP_047278962.1  intracellular hyaluronan-binding protein 4 isoform X1

  4. XM_005251812.4XP_005251869.1  intracellular hyaluronan-binding protein 4 isoform X2

    Conserved Domains (1) summary
    pfam04774
    Location:102206
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    108621878..108663114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362392.1XP_054218367.1  intracellular hyaluronan-binding protein 4 isoform X3

  2. XM_054362391.1XP_054218366.1  intracellular hyaluronan-binding protein 4 isoform X3

  3. XM_054362389.1XP_054218364.1  intracellular hyaluronan-binding protein 4 isoform X1

  4. XM_054362390.1XP_054218365.1  intracellular hyaluronan-binding protein 4 isoform X2